【个人简介】

秦大江，研究员，香港大学李嘉诚医学院生物医学系博士，广州医科大学附属第五医院（广州再生医学与健康广东省实验室附属医院）副院长；生物岛实验室副主任，细胞药物创新研究中心客座研究员；中国科学院广州生物医药与健康研究院客座研究员。中国医药生物技术协会临床研究专业委员会副主任委员；中国药理学会临床药理专委会常务委员；广东省精准医学应用学会干细胞与再生医学分会副主任委员；广东省研究型医院学会智慧医院专业委员会副主任委员；广东省医学会细胞治疗分委会常务委员；广州市医院协会副会长。

【研究方向】

于2007年在我国率先突破体细胞重编程为多能干细胞的iPS技术，主要研究方向为衰老与神经退行性疾病，疾病iPS模型与干细胞技术改进及临床应用研究。

【科研项目】

1．国家自然科学基金面上项目，PS1突变诱导血脑屏障内皮细胞Tau蛋白毒性和紧密连接缺失的机制研究，2025-01-01至2028-12-31，49万元，主持，在研

2．国家重大科技专项，功能增强型iNK细胞的核心材料研发及在肺癌中的治疗应用研究，2024-10-01至2027-09-30，558万元，子课题负责人，在研

3. 广州市重点研发项目，石蒜碱靶向调控错误折叠和异位的TDP-43对肌萎缩侧索硬化症的治疗研究， 2025-11-01至2028-10-31，50万，主持，在研

4. 科技部重点研发计划项目，基于动员内源性神经干细胞修复脊髓损伤的机制与转化研究，2016-01-01至2020-12-31)，200万元，主持，结题

5. 科技部863课题，临床级干细胞分离培养、扩增诱导和保存运输等产业化关键技术研，2011-01-01至2015-12-31)，175万元，主持，结题

6．国家自然科学基金青年项目，基于Progerin诱导的散发型帕金森症iPS细胞模型建立，2016-01-01至2018-12-31，20万元，主持，结题

7.国家自然科学基金面上项目，基于诱导多能干细胞技术的I 型神经纤维瘤疾病模型研究，2011-01-01至2013-12-31，35万元，主持，结题

8.科技部973项目，干细胞调控相关的生物学模型的研究和建立，2009-01-01至2013-12-31，285万元，主持，结题

9.中国科学院知识创新工程重要方向项目，利用iPS技术探索治疗ß地中海贫血新方法，2011-01-01至2013-12-31，80万元，主持，结题

【代表性论文及著作】

1. Qin D, Li W, Zhang J, Pei DQ*. Direct generation of ES-like cells from unmodified mouse embryonic fibroblasts by Oct4/Sox2/Myc/Klf4. Cell research, 2007, 17(11):959-962.

2. Qin D, Gan Y, Shao K, Wang H, Li W, Wang T, He W, Xu J, Zhang Y, Kou Z, Zeng L, Sheng G, Esteban MA, Gao S, Pei DQ*. Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors. Journal of Biological Chemistry, 2008, 283(48):33730-33735.

3. Huang C, Qin D.*.Role of Lef1 in sustaining self-renewal in mouse embryonic stem cells. J. Genet. Genomics, 2010 Jul 20;37 (2010) 1-9.

4. Su H, Wang L, Cai J, Yuan Q, Yang X, Yao X, Wong WM, Huang W, Li Z, Wan JB, Wang Y, Pei D, So KF, Qin D*, Wu W*. Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle. Stem Cell Res. 2013 Mar 5;11(1):529-539.

5. Chen J, Li W, Li Y, He S, Li L, Liang L, Song Y, Qin D*, Zheng H*. MicroRNA-128-3p impaired water maze learning by suppressing Doublecortin expression in both wild type and Aβ-42 infused mice. Neuroscience Letters. Volume 626, 28 July 2016, Pages 79-85.

6. Yao H, Xue J, Wang Q, Xie R, Li W, Liu S, Cai J, Qin D*, Wang DA*, Ren L*. Glucosamine-modified polyethylene glycol hydrogel-mediated chondrogenic differentiation of human mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:661-670.

7. Chong CM, Ke M, Tan Y, Huang Z, Zhang K, Ai N, Ge W, Qin D*, Lu JH*, Su H*. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling. Cell Death Dis. 2018 Aug 29;9(9):879. doi: 10.1038/s41419-018-0945-7.

8. Tan Y, Ke M, Huang Z, Chong CM, Cen X, Lu JH, Yao X*, Qin D*, Su H*. Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson’s Disease. Aging and Disease. 2019 Oct 1;10(5):1037-1048.

9. Ke M, Chong CM, Zeng H, Huang M, Huang Z, Zhang K, Cen X, Lu JH, Yao X*, Qin D*, Su H*. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11(2):130. doi: 10.1038/s41419-020-2312-8.

10. Ke M, Chong CM, Zhu Q, Zhang K, Cai CZ, Lu JH*, Qin D*, Su H*. Comprehensive Perspectives on Experimental Models for Parkinson's Disease. Aging and Disease. 2021 Feb 1;12(1):223-246. doi: 10.14336/AD.2020.0331. eCollection 2021 Feb.

11. Wang B, Pang MR, Song YC, Wang HX, Pan Q, Bai SS, Lei XX, Wei SK, Zhang XT, Wang X, Yang YK, Li Y, Wang Y, Xu HJ, Hang L, Cheng B, Lee YK*, Qin D*, Li G*. Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat-shock protein family. Bioengineering & Translational Medicine, 2022 May, doi: 10.1002/btm2.10354

12. Xu H, Wang J, Wu D, Qin D*. A hybrid hydrogel encapsulating human umbilical cord mesenchymal stem cells enhances diabetic wound healing. J Mater Sci Mater Med. 2022 Jul 18;33(8):60. doi: 10.1007/s10856-022-06681-4.

13. Wu H, Li C, Masood M, Zhang Z, González-Almela E, Castells-Garcia A, Zou G, Xu X, Wang L, Zhao G, Yu S, Zhu P, Wang B, Qin D*, Liu J*. Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation. Cells. 2022 Aug 8;11(15):2460. doi: 10.3390/cells11152460.

14. Chong CM, Tan Y, Tong J, Ke M, Zhang K, Yan L, Cen X, Lu JH, Chen G, Su H*, Qin D*. Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway. Cell Biosci. 2022 Aug 14;12(1):131. doi: 10.1186/s13578-022-00874-8.

15. Cen XT, Chen Q, Wang B, Xu H, Wang X, Ling Y.,Zhang X, Qin D*. UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1. Cell Communication and Signaling. 2022 Nov 28;20(1):191. doi: 10.1186/s12964-022-00996-z.

16. Huo Q, Lv J, Zhang J, Huang H, Hu H, Zhao Y, Zhang X, Wang Y, Zhou Y, Qiu J, Ye Y, Huang A, Chen Y, Qin L, Qin D*, Li P*, Cai G*. c-Met is a chimeric antigen receptor T-cell target for treating recurrent nasopharyngeal carcinoma. Cytotherapy. 2023 Oct;25(10):1037-1047. doi: 10.1016/j.jcyt.2023.06.004. Epub 2023 Jul 11. PMID: 37436338.

17. Xu H, Wang B, Li A, Wen J, Su H*, Qin D*. Mesenchymal Stem Cells-based Cell-free Therapy Targeting Neuroinflammation. Aging and disease. 2024 May 7; 15(3): 965–976.

18. Yao Y, Jin C, Liao Y, Huang X, Wei Z, Zhang Y, Li D, Su H*, Han W*, Qin D*. Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency. Aging and disease .2024 Aug 1; 15(4): 1952–1968.

19. Huang M, Liu YU, Yao X*, Qin D*, Su H*. Variability in SOD1-associated amyotrophic lateral sclerosis: geographic patterns, clinical heterogeneity, molecular alterations, and therapeutic implications. Transl Neurodegener. 2024 May 29;13(1):28. doi: 10.1186/s40035-024-00416-x.

20. Zhang R, Wu M, Xiang D, Zhu J, Zhang Q, Zhong H, Peng Y, Wang Z, Ma G, Li G, Liu F, Ye W, Shi R, Zhou X, Babarinde IA, Su H, Chen J, Zhang X*, Qin D*, Hutchins AP*, Pei D*, Li D*. A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development. Cell Stem Cell. September 5, 2024, 31, 1–17.

21. Chen H, Wen Y, Wu W, Zhang Y, Pan X, Guan Y, Qin D*. Prediction of Malignancy and Pathological Types of Solid Lung Nodules on CT Scans Using a Volumetric SWIN Transformer. J Imaging Inform Med. 2025 Jun;38(3):1509-1517. doi: 10.1007/s10278-024-01090-1. Epub 2024 Oct 14. PMID: 39402355; PMCID: PMC12092873

22. Satyanarayanan SK, Han Z, Xiao J, Yuan Q, Yung WH, Ke Y, Chang RC, Zhu MH, Su H, Su KP, Qin D*, Lee SMY*. Frontiers of Neurodegenerative Disease Treatment: Targeting Immune Cells in Brain Border Regions. Brain Behav Immun. 2024 Oct 6;123:483-499. doi: 10.1016/ j.bbi.2024.10.007.

23. Wen J, Li Y, Qin Y, Yan L, Zhang K, Li A, Wang Z, Yu F, Lai J, Yang W, Liu YU*, Qin D*, Su H*. Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis. Pharmacol Res. 2024 Nov 26:210:107518. doi: 10.1016/j.phrs.2024.107518.

24. Shi J, Chen Q, Lai J, Zhu J, Zhang R, Mazid M, Li D*, Su H*, Qin D*. Impact of c-JUN deficiency on thalamus development in mice and human neural models. Cell Biosci. 2024; 14: 149. Published online 2024 Dec 20. doi: 10.1186/s13578-024-01303-8.

25. Yin M, Li Y, Sun Z, Wu X, Ding L, Zhang Q, Zhou H, Zhang M, Qin D*, Qin B*, Wang L*. α-Ketoglutarate inhibits the pluripotent-to-totipotent state transition in stem cells. FEBS J. 2025 Feb 10. doi: 10.1111/febs.70008. Epub ahead of print. PMID: 39930914.

26. Satyanarayanan SK, Yip TF, Han Z, Zhu H, Qin D*, Lee SMY*. Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders? Front Med (Lausanne). 2025 Mar 26;12:1458281. doi: 10.3389/fmed.2025.1458281. PMID: 40206484; PMCID: PMC11979212.

27. Wu D, Liu R, Cen X, Dong W, Chen Q, Lin J, Wang X, Ling Y, Mao R, Sun H, Huang R, Su H*, Xu H*, Qin D*. Preclinical study of engineering MSCs promoting diabetic wound healing and other inflammatory diseases through M2 polarization. Stem Cell Res Ther. 2025; 16: 113. Published online 2025 Mar 5.

28. Wei Z, Liu C, Chen J, Yao Y, Qin D*. Krüppel-like factor 4 transcription factor in blood-brain barrier endothelial cells: A potential role in Alzheimer's disease. Animal Model Exp Med. 2025 May;8(5):819-828. doi: 10.1002/ame2.70015. Epub 2025 Mar 26. PMID: 40135492; PMCID: PMC12107370.

29. Hu Z, Wang T, Li X, Luo Y, Wang X, Li C, Zhang Z, Wang X, He J, Zhan Y, Liang X, Zheng S, Li Y, Zong Y, Liu L, Bi J, Zhang Y, Zhou N, Liu H, Ban L*, Qin D*, Fang Y*. A Multicenter, Randomized, Open-Label, Active-Controlled, Parallel-Group Study Evaluating the Pharmacokinetics of Single-Dose Tapentadol Hydrochloride Intravenous Infusion and Tapentadol Hydrochloride Oral Tablets in Patients with Pain. Eur J Drug Metab Pharmacokinet. 2025 Nov;50(6):529-539. doi: 10.1007/s13318-025-00965-0. Epub 2025 Oct 9. PMID: 41066048.

30. Huang S, Li A, Ling Y, Yang X, Wang J, Yuan J*, Qin D*, Yao X*. Pharmacological Activation of Mitophagy Confers Neuroprotective Benefits for Amyotrophic Lateral Sclerosis. Aging Dis. 2025 Dec 14. doi: 10.14336/AD.2025.1224. Epub ahead of print. PMID: 41400574.

31. Sun F, Zou B, Li H, Xu C, Luo Q, Wang C, Xu P, Pei D, Chen J, Qin D*, Zhang Y*, He J*. Structural basis for BCL7B-mediated ncBAF-nucleosome engagement. Nucleic Acids Res. 2026 Feb 5;54(4):gkag092. doi: 10.1093/nar/gkag092. PMID: 41657245; PMCID: PMC12884074.

32. Li A, Xiao X, Liu G, Li K, Ling Y, Deng S, Xu C, Cao SQ, Wen J, Lu G, Yang G, Fang EF, Qin D*, Su H*. Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β-TFEB signaling axis. Pharmacol Res. 2026 May;227:108172. doi: 10.1016/j.phrs.2026.108172. Epub 2026 Mar 28. PMID: 41912102; PMCID: PMC13132972.

33. Li A, Xiao X, Qin D*, Su H*. Discovery of a novel TFEB activator targeting lysosomal dysfunction in amyotrophic lateral sclerosis using artificial intelligence-based virtual screening. Autophagy. 2026 Aug;22(8):2041-2042. doi: 10.1080/15548627.2026.2659295. Epub 2026 Apr 20. PMID: 41968679; PMCID: PMC13390523.

【所获荣誉和奖励】

获奖成果：

2009年度广东省科学技术奖一等奖“诱导多能干细胞机理与技术研究”（第二完成人）

2013年度国家自然科学二等奖"干细胞多能性与重编程机理研究" （第四完成人）

2020年度广东省自然科学奖一等奖“线粒体信号调控细胞命运研究”

个人荣誉：

2011年入选中国科学院“青年促进会”首届会员。

2015入选年“广东特支计划” 百千万工程青年拔尖人才。

2017年作为团队核心成员获得广东省南粤创新奖。

2017年作为团队骨干成员获得中国科学院杰出科技成就奖。