【个人简介】

张天富，广州医科大学生物医学工程学院教授，学术及专业型硕士生导师。博士毕业于香港科技大学，曾于香港城市大学-香港心脑血管健康工程中心从事研究工作。目前担任 Exploration期刊青年顾问、Interdisciplinary Medicine期刊青年编委、BME Horizon期刊青年编委。

招生专业：生物医学工程、药学

已培养硕士生人数：3

电子邮箱：zhangtf@gzhmu.edu.cn

个人主页：https://nsxz.gzhmu.edu.cn/homepage/zhangtianfu/index.htm

【研究方向】

1. 新型荧光探针的开发：具有聚集诱导发光（AIE）性质的多功能荧光探针的设计与开发，并探索其在疾病诊断中的应用，包括肿瘤跟踪、中风、动脉粥样硬化和阿尔茨海默病诊断。

2. 微环境调控：研究纳米/高分子材料的精准递送及其对疾病微环境的特异性调控机制；

3. 创新治疗体系构建：开发基于纳米递送材料的联合治疗新策略（如光疗、免疫治疗等），致力于攻克癌症、感染性疾病及肺部疾病等重大疾病。

近五年以第一/通讯作者身份在Adv. Mater., Angew. Chem., JACS, Mater. Today., Adv. Mater. Funct, ACS Nano, Adv. Sci等高水平期刊（IF＞10）发表论文40余篇，其中3篇为ESI高引论文，2篇为封面论文。管理国家基金委联合重点项目、青年基金、广东省面上基金、市级高层次人才项目等500余万。相关成果已申请美国专利2项,中国专利4项。以第三完成人身份获得省级自然科学将二等奖。获得2021和2022年心脑血管健康工程领域优秀学者奖，《Aggregate》（IF=13.3）期刊最佳贡献奖，以及学术会议优秀报告等多个奖项。

【科研项目】

1. 国家自然科学基金-青年科学基金项目，2024-01-01至2026-12-31，30万，在研，主持。

2. 广东省自然科学基金-面上项目，2024-01-01至2026-12-31，15万，在研，主持。

3. 高大建项目经费，2023-02-06至2028-12-31，300万，在研，主持。

4. 广州市科技局青年启航项目，2024-01-01至2026-12-31，5万，在研，主持。

5. 广东省教育厅普通高校重点领域专项，2026-01-01至2027-12-31，15万，在研，主持。

【代表性论文及著作】

1. Shipeng Ning,# Ping Shangguan,# Xinyan Zhu,# Xinwen Ou,# Kaiyuan Wang, Meng Suo, Hanchen Shen, Xiuxin Lu, Xianqing Wei, Tianfu Zhang,* Xiaoyuan Chen,* and Ben Zhong Tang* Pyridinium Rotor Strategy toward a Robust Photothermal Agent for STING Activation and Multimodal Image-Guided Immunotherapy for Triple-Negative Breast Cancer. J. Am. Chem. Soc. 2025, 147 (9), 7433-7444. (论文，中科院一区，IF = 16.0)

2. Shijie Zhen,# Zhe Xu,# Meng Suo,# Teng Zhang, Meng Lyu, Tianwei Li, Tianfu Zhang,* Meijing Li,* Zujin Zhao,* Ben Zhong Tang* NIR-II AIE Liposomes for Boosting Type-I Photodynamic and Mild-Temperature Photothermal Therapy in Breast Cancer Treatment. Adv. Mater. 2024, 37, 2411133. (论文，中科院一区，IF = 26.8)

3. Meng Suo,# Ping Shangguan,# Shiquan Deng, Yixiong Liu, Keke Wu, Shipeng Ning, Xing-Jie Liang*, Ben Zhong Tang*, Tianfu Zhang* Facilitating direct presentation of tumor antigens to activate anti-tumor immunity by AIE phototherapy-potentiated hybrid vaccine Mater. Today 2025, 90, 270-284. (论文，中科院一区，IF = 22.0)

4. Qingyong Xu,*# Minmin Zhang,# Qinqin Huang,# Song Gao, Sitong Chu, Qi Li, Wanyao Chen, Xinglong Zhang, Tianfu Zhang,* Ben Zhong Tang,* and Shipeng Ning* Organic AIE Nanoradiosensitizer Potentiates X-Ray Triggered Continuous Reactive Oxygen Species Generation for Potent Cancer Radioimmunotherapy. Adv. Mater. 2025, 2502898.  (论文，中科院一区，IF = 26.8)

5. Hanchen Shen,# Hongbin Wang,# Jianlan Mo,# Jianyu Zhang, Changhuo Xu, Feiyi Sun, Xinwen Ou, Xinyan Zhu, Lidong Du, Huaqiang Ju, Ruquan Ye, Guangfu Shi, Ryan T. K. Kwok, Jacky W. Y. Lam, Jianwei Sun, Tianfu Zhang,* Shipeng Ning,* Ben Zhong Tang* Unrestricted Molecular Motions Enable Mild Photothermy for Recurrence-Resistant FLASH Antitumor Radiotherapy. Bioact. Mater. 2024, 37, 299. (论文，中科院一区，IF = 18)

6. Tianfu Zhang,*# Wei Ping,# Meng Suo,# You Pan, Rong Huang, Jingqi Chen, Meng Lyu, Ni Zhang,* Shipeng Ning,* Ben Zhong Tang* Stimuli-Responsive Hydrogel Potentiating AIE Photothermal Therapy Against Cancer Stem Cell-Induced Tumor Metastasis. ACS Nano 2024, 18, 20313. (论文，中科院一区，IF = 15.8)

7. Tianfu Zhang,*# You Pan,# Meng Suo,# Meng Lyu, Jacky Wing Yip Lam, Zhaokui Jin,* Shipeng Ning,* Ben Zhong Tang* Photothermal-Triggered Sulfur Oxide Gas Therapy Augments Type I Photodynamic Therapy for Potentiating Cancer Stem Cell Ablation and Inhibiting Radioresistant Tumor Recurrence Adv. Sci. 2023, 10, 2304042. (论文，中科院一区，IF = 17.51)

8. You Pan,# Qinqin Huang,# Meng Suo,# Meng Lyu, Yi Jiang, Shile, Wang, Wenxue Tang, Shipeng Ning,* Tianfu Zhang* Near-infrared laser-activated aggregation-induced emission nanoparticles boost tumor carbonyl stress and cancer immunotherapy Aggregate 2023, e432. (论文，中科院一区，IF = 13.3)

9. Shipeng Ning,# Xing Zhang,# Meng Suo,# Meng Lyu, You Pan, Yi Jiang, Huawei Yang, Jacky Wing Yip Lam, Tianfu Zhang,* Linghui Pan,* Ben Zhong Tang* Platelet-derived exosomes hybrid liposomes facilitate uninterrupted singlet oxygen generation to enhance breast cancer immunotherapy. Cell Rep. Phys. Sci. 2023, 4, 101505. (论文，中科院一区，IF = 8.9)

10. Shipeng Ning, Meng Lyu, Daoming Zhu, Jacky W. Y. Lam, Qinqin Huang,* Tianfu Zhang,* Ben Zhong Tang* Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge. ACS Nano, 2023, 17, 10206. (论文，中科院一区，IF = 15.8)

11. Shipeng Ning,# Meng Suo,# Qinghua Huang,# Song Gao, Kun Qiao, Meng Lyu, Qinqin Huang,* Tianfu Zhang,* Ben Zhong Tang* Biomimetic fusion liposomes boosting antitumor immunity and promote memory T cell differentiation to inhibit postoperative recurrence of breast cancer. Nano Today, 2024, 54, 102106. (论文，中科院一区，IF = 18.2)

12. Meng Suo,# Hanchen Shen,# Meng Lyu,# Yi Jiang, Xiaoming Liao, Wei Tang, You Pan, Tianfu Zhang, * Shipeng Ning, * and Ben Zhong Tang*. Biomimetic Nano-Cancer Stem Cell Scavenger for Inhibition of Breast Cancer Recurrence and Metastasis after FLASH-Radiotherapy. Small 2024, 2400666. (论文，Q1，IF = 13)

13. Tianfu Zhang,# Xing Yang,# Xinwen Ou,# Michelle M. S. Lee, Jianyu Zhang, Changhuo Xu, Xinghua Yu, Ping Gong,* Jacky W. Y. Lam, Pengfei Zhang,* Ben Zhong Tang* Tailoring Amphiphilic Structure of Zwitterionic AIE Photosensitizers to Boost Antitumor Immunity. Adv. Mater. 2023, 35, 2303186. (论文，中科院材料一区，IF = 29.4)

14. Tianfu Zhang,# Jianyu Zhang,# Fu-Bing Wang, Hui Cao, Daoming Zhu, Xiaoyu Chen, Changhuo Xu, Xueqin Yang, Wenbin Huang, Zhaoyu Wang, Jiefei Wang, Zikai He, Zheng Zheng,* Jacky Wing Yip Lam,* Ben Zhong Tang* Mitochondria-Targeting Phototheranostics by Aggregation-Induced NIR-II Emission Luminogens: Modulating Intramolecular Motion by Electron Acceptor Engineering for Multi-Modal Synergistic Therapy. Adv. Funct. Mater. 2022, 32, 2110526. (论文，中科院材料一区，IF= 19.9)

15. Tianfu Zhang,# Yuanyuan Li,# Zheng Zheng, Ruquan Ye, Yiru Zhang, Ryan T.K. Kwok, Jacky W. Y. Lam and Ben Zhong Tang*. In Situ Monitoring Apoptosis Process by a Self-Reporting Photosensitizer. J. Am. Chem. Soc. 2019, 141, 5612. (论文，中科院化学一区，IF= 16.8)

16. Tianfu Zhang,# Xiaoyu Chen,# Congmin Yuan,# Xiaobin Pang, Ping Shangguan, Lulu Han, Yisheng Liu, Jianwei Sun, Jacky W. Y. Lam, Jiefei Wang,* Bingyang Shi,* Ben Zhong Tang* Near‐Infrared Aggregation‐Induced Emission Luminogens for In Vivo Theranostics of Alzheimer’s Disease. Angew. Chem. Int. Ed. 2023, 62, e202211550. (论文，中科院化学一区，IF= 16.8)

17. Tianfu Zhang,# Zeming Liu,# Wenxue Tang,# Meng Lyu, Jacky Wing Yip Lam, Qinqin Huang,* Ben Zhong Tang* Mitochondria-Targeting Type I AIE Photosensitizer Combined with H2S Therapy: Uninterrupted Hydroxyl Radical Generation for Enhancing Tumor Therapy. Nano Today 2022. 46, 101620. (论文，中科院化学一区，IF= 20.7)

【所获荣誉和奖励】

1. 获得2021和2022年心脑血管健康工程领域优秀学者奖。

2. 获得《Aggregate》（IF=13.3）期刊最佳贡献奖。

3. 以第三完成人身份获得广西自然科学二等奖。