秦燕 博士 广州医科大学生物医学工程学院“南山学者-杰出人才”特聘教授，硕士生、博士生导师

l国家重点研发计划（干细胞及转化）首席科学家

l科技部科技创新领军人才--万人计划

l国家“优秀青年基金”获得者

主要从事核糖体结构功能与疾病的发生、发展机制研究。致力于研究干细胞的蛋白翻译调控研究，特别对慢性肺病的发生、发展过程中的诊断、治疗提出新方案。发现核糖体的"倒退"（Qin et al., Cell, 2006）及其诱导因子EF4 （Qin*, Nature Structural & Molecular Biology, 2008, 2012, 2014, 2016a,b）在人类肿瘤、小鼠、线虫以及大肠杆菌中的生理功能与病理意义；核糖体异质性在干细胞中的作用（Qin*, Nature, 2022）。在Cell，Nature系列（Nature Reviews Microbiology, Nature Structural & Molecular Biology 等），PNAS等学术杂志以（唯一或共同）第一作者、通讯作者发表研究论文近50篇，并拥有多项专利。以首席科学家、项目负责人等身份执行\完成了科技部重点研发计划（首席科学家、项目负责人、参与骨干），自然科学基金委重点项目、优青、面上项目（负责人）、中国科学院重点项目（负责人、参与骨干）、先导项目（子课题负责人）等。

研究方向：

1.肺病中的核糖体生物学： 2022 年Nature 发表 (Nature, 612：725-731）发现哺乳动物组织特异性核糖体对生殖干细胞发生过程的决定性作用。2023年Signal Transduction and Targeted Therapy (STTT, 2023,8: 136）发现肺泡上皮细胞核糖体对肺纤维化发生过程的决定性作用，发现了核糖体、线粒体对肺纤维化病变过程的调控系统，特别是翻译因子（mtEF4）对的精准调控机制，及其与核糖体的精细调控分子机制，相关工作发表在Nature Structural & Molecular Biology ，PNAS，Nature Reviews Microbiology等学术杂志上并申请获批多项专利，为相关疾病的诊治提供了重要理论依据和应用潜力。

2.干细胞机制：蛋白质翻译调控在干性维持与转换中的作用

3.肺病的靶向药物：靶向肺病的发生、发展过程中的疾病模型、诊断、治疗

　电子邮件(E-mail) qiny@ibp.ac.cn

l学习与工作经历

1995-1999年 南开大学，生物学学士

2000-2006年 德国马-普学会，博士学位，留任博士后

2006年—2023 中国科学院生物物理研究所研究员，RNA平台首席技术专家

2023年—至今 广州医科大学 生物医学工程学院

l代表性论文

1.Qin Y, Polacek N, Vesper O, Staub E, Einfeldt E, Wilson DN, Nierhaus KH (2006) The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome. Cell 127(4):721-733.

2.Li H, Huo Y, He X, Yao L, Zhang H, Cui Y, Xie W, Zhang D, Cheng Y, Cuo Y, Cao X, Zhu Y, Jiang T, Guo X*, Qin Y* and Sha J*(2022) (*corresponding author) A male germ-cell-specific ribosome controls male fertility, Nature, https://www.nature.com/articles/s41586-022-05508-0

3.Zhang N, Zhao Z, Zhao Y, Yang L, Xue Y, Feng Y, Luo J, Chen R, Wei W and Qin Y*. (2023) (*corresponding author) TGF-β changes cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy Signal Transduction and Targeted Therapy (IF 38.12) 2023:8 (136)

4.Wang L, Yang F, Zhang D, Chen Z, Xu R, Nierhaus K H, Gong W and Qin Y* (2012) (*corresponding author) A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nat. Struct. Mol. Biol. 19(4):403-410

5.Yamamoto H^#, Qin Y^#, Achenhach J^#, Li X, Kijek J, Kijek J, Sphan CMT and Nierhaus HK (2014) (^#co-first author) EF-G and EF4: Translocation and back-translocation on the bacterial ribosome. Nat. Rev. Microbiol. (invited review)12 (2): 89-100

6.Liu G, Song G, Zhang D, Zhang D, Li Z, Lyv Z, Dong J, Aachenbach J, Gong W, Zhao X, Nierhaus K H and Qin Y* (2014) (*corresponding author) EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon–anticodon duplex. Nat. Struct. Mol. Biol. 21(9): 817-824

7.Zhang D, Yan K, Liu G, Cao X, Song G, Shi Y, Luo J, Cheng E, Wu S, Jiang T, Lou J, Gao N* and Qin Y*(2016) (*corresponding author) EF4 disengages tRNA's CCA-ends to cause back-translocation in elongating ribosome. Nat. Struct. Mol. Biol. 23(2) 125-131

8.Gao Y, Zhang D, Bai X, Li Z, Chen L, Zheng Q, Jiang T, Gao F, Yuan J and Qin Y* (2016) (*corresponding author) Mammalian elongation factor 4 controls mitochondrial proteostasis for male fertility. Nat. Struct. Mol. Biol. 23(5) 441-449

l全部已发表论文

1.Dong Z, Wang X, Wang P, Bai M, Wang T*, Chu Y* and Qin Y* (2024) (*corresponding author). Idiopathic pulmonary fibrosis caused by damaged mitochondria and imbalanced protein homeostasis in alveolar epithelial type II cell. Advanced Biology (IF 3.7) doi: 10.1002/adbi.202400297

2.Si Q, Bai M, Wang X*, Wang T* and Qin Y* (2024) (*corresponding author) Photonanozyme-Kras-Ribosome Combination Treatment of Non-Small Cell Lung Cancer after COVID-19. Front. Immunol.( Frontiers in Immunology), (IF 5.7) 2024: 15| doi: 10.3389/fimmu.2024.1420463

3.Yang B, Cao L, Ge K*, Lv C, Zhao Z, Zheng T, Gao S, Zhang J, Wang T*, Jiang J* and Qin Y* (2024) (*corresponding author) FeSA-Ir/Metallene Nanozymes Induce SequentialFerroptosis-Pyroptosis for Multi-Immunogenic ResponsesAgainst Lung Metastasis, Small, (IF 13.3) https://onlinelibrary.wiley.com/doi/10.1002/smll.202401110

4.Zhang N, Zhao Z, Zhao Y, Yang L, Xue Y, Feng Y, Luo J, Chen R, Wei W and Qin Y*. (2023) (*corresponding author) TGF-β changes cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy Signal Transduction and Targeted Therapy (IF 38.12) 2023

5.Li H, Huo Y, He X, Yao L, Zhang H, Cui Y, Xie W, Zhang D, Cheng Y, Cuo Y, Cao X, Zhu Y, Jiang T, Guo X*, Qin Y* and Sha J*(2022) (*corresponding author) A male germ-cell-specific ribosome controls male fertility, Nature (IF 69.012) https://doi.org/10.1038/s41586-022-05508-0, https://www.nature.com/articles/s41586-022-05508-0

6.Yang B, Zhang Y, Sun L, Wang J, Zhao Z, Huang Z, Mao W, Xue R, Chen R, Luo J*, Wang T*, Jiang J* and Qin Y* (2022) (*corresponding author) Modulated Ultrasmall γ-Fe2O3 Nanocrystal Assemblies for Switchable Magnetic Resonance Imaging and Photothermal-Ferroptotic-Chemical Synergistic Cancer Therapy, Advanced Functional Materials (IF 19.901) https://doi.org/10.1002/adfm.202211251

7.Wang J, Yang B, Lv C, Chen T, Sun L, Sun L, Hao J, Ding F*, Wang T*, Jiang J* and Qin Y* (2022) (*corresponding author) Amino porphyrin-peptide assemblies induce ribosome damage and cancer stem cell inhibition for an enhanced photodynamic therapy, Biomaterials (IF 15.551) doi.org/10.1016/j.biomaterials.2022.121812

8.Wang Q, Wang Y, Li S, Zhou A and Qin Y*(2022) (*corresponding author) Organelle biogenesis: Ribosomes as organizer and performer. Science Bulletin (IF 20.085)10.1016/j.scib.2022.07.023

9.Xu X, Wang L, Ahmed T, Cao X, Zhang Z, Wang M, Lv Y, Kanwal S, Tariq M, Lin R, Zhang H, Huang Y, Peng H, Lin D, Shi X, Geng D, Liu B, Zhang X, Yi W, Qin Y, Esteban M, and Qin B* (2021) mTORC1-eIF4F axis controls paused pluripotency EMBO reports

10.Zhang K; Jiao X; Zhou L; Wang C*; Qin Y*; Wen Y* (2021) (*corresponding author) Nanofibrous composite aerogel with multi-bioactive and fluid gating characteristics for promoting diabetic wound healing. Biomaterials 276, 121040

11.Wu H*, Wei H, Zhang D, Sehgal SA, Zhang D, Wang X, Qin Y, Liu L*, and Chen Q* (2020) (*corresponding author), Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. Redox Biol. 36, 101661

12.Zhang M, et al., Qin Y, …Chen L*, Hanna JH* and Esteban MA* (2020) (*corresponding author) β-catenin safeguards the ground state of pluripotency by strengthening the robustness of the transcriptional apparatus. Sci. Adv. 6(29): eaba1593

13.Song G, Xu B, Shi H, Zhang Y, Zhang D, Cao X, Liu Z, Guo R, Guan Y, Chu Y, Zhang X*, Lou J*, and Qin Y*. (2020) (*corresponding author) Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF. Int. J. Biol. Macromol. 160:1212-1219

14.Zhang K, Bai X, Yuan Z, Cao Xintao, Jiao X, Qin Y*, Wen Y* and Zhang X (2020) (*corresponding author) Cellular nanofiber structure with secretory activity-promoting characteristics for multicellular spheroid formation and hair follicle regeneration. ACS Appl. Mater. Interfaces 12(7):7931–7941

15.Zhang K, Bai X, Yuan Z, Cao Xintao, Jiao X, Li Y, Qin Y*, Wen Y* and Zhang X. (2019) (*corresponding author) Layered nanofiber sponge with improved capacity of blood coagulation and wound healing. Biomaterials 204:70–79

16.Li G and Qin Y* (2018) A brief review: the mitochondrial translation factor EF4 regulated mitochondrial respiratory chain and induced the production of ROS. Free Radic. Res. (invited review) 52(11-12):1250-1255.

17.Zhou Z, Hu Y, Li A, Li Y, Zhao H, Wang S, Otecko NO, Zhang D, Wang J, Liu Y, Irwin DM, Qin Y & Ya-Ping Zhang* (2018) Genome wide analyses uncover allele-specific RNA editing in human and mouse. Nucleic Acids Res. 46(17):8888-8897

18.Wang F, Zhang L, Bai X, Cao X, Jiao X, Huang Y, Li Y, Qin Y^* and Wen Y*(2018) (*corresponding author) Stimuli-responsive nanocarrier for co-delivery of mir-31 and doxorubicin to suppress high mtEF4 cancer. ACS Appl. Mater. Interfaces 10(26):22767-22775

19.Zhu P, Liu Y, Zhang F, Bai X , Chen Z , Shangguan F , Zhang B , Zhang L , Chen Q , Xie D , Lan L ,  Xue X , Liang X , Lu B^*, Wei T^* and Qin Y^* (2018)(*corresponding author) Human EF4 regulates cancer bioenergetics by acting as mitochondrial translation switch. Cancer Res. 78(11): 2813–2824

20.Xu B, Song G and Qin Y^*(2018) (*corresponding author) smFRET study progress in the dynamics of ribosome translocation. Prog. Biochem. Biophys (invited review) 45 (3): 314-324

21.Hao Y#, Zhang L#, Niu Y, Cai T, Luo J, He S, Zhang B, Zhang D, Qin Y, Yang F and Chen R* (2018) (*corresponding author) SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci. Brief. Bioinform. 19(4)636-643

22.Guangtao Song and Qin Y* (2016) (*corresponding author) EF4 reveals the energy barrier for tRNA back-translocation in the peptidyl transferase center. RNA Biol. (invited review)13(10)934-939

23.Xintao Cao and Qin Y* (2016) (*corresponding author) Mitochondrial translation factors reflect coordination between organelles and cytoplasmic translation via mTOR signaling: Implication in disease. Free Radical Bio. Med. (invited review) 100:231-237

24.Gao Y, Zhang D, Bai X, Li Z, Chen L, Zheng Q, Jiang T, Gao F, Yuan J and Qin Y* (2016) (*corresponding author) Mammalian elongation factor 4 controls mitochondrial proteostasis for male fertility. Nat. Struct. Mol. Biol. 23(5) 441-449

25.Zhang D, Yan K, Liu G, Cao X, Song G, Shi Y, Luo J, Cheng E, Wu S, Jiang T, Lou J, Gao N* and Qin Y*(2016) (*corresponding author) EF4 disengages tRNA's CCA-ends to cause back-translocation in elongating ribosome. Nat. Struct. Mol. Biol. 23(2) 125-131

26.Zhang D, Yan K, Zhang Y, Liu G, Cao X, Song G, Xie Q*, Gao N* and Qin Y* (2015) (*corresponding author) New insights into the enzymatic role of EF-G in ribosome recycling. Nucleic Acids Res.43 (21): 10525-10538

27.Zhang Y, Mandava C, Cao W, Li X, Zhang D, Li N, Zhang Y, Zhang X, Qin Y, Mi K, Lei J*, Sanyal S*, Gao N* (2015) (*corresponding author) HflX is a ribosome splitting factor rescuing stalled ribosomes under stress conditions. Nat. Struct. Mol. Biol. 22 (11): 906-913

28.Qin Y* (2014) (*co-corresponding author) 40th Anniversary Series: Ribosomal translocation and back-translocation during protein synthesis. Prog. Biochem. Biophys (invited review) 40(6):12

29.Liu G, Song G, Zhang D, Zhang D, Li Z, Lyv Z, Dong J, Aachenbach J, Gong W, Zhao X, Nierhaus K H and Qin Y* (2014) (*corresponding author) EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon–anticodon duplex. Nat. Struct. Mol. Biol. 21(9): 817-824

30.Yang F, Gao Y, Li Z, Chen L, Xia Z, Xu T* and Qin Y* (2014) (*co-corresponding author) Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans. BBA Bioenergetics 1837(10): 1674-1683

31.Yang F, Li Z, Hao J and Qin Y* (2014) (*corresponding author) EF4 knockout E. coli cells exhibit a lower level of intracellular biosynthesis under acidic stress. Protein & Cell 5(7): 563-570

32.Yamamoto H^#, Qin Y^#, Achenhach J^#, Li X, Kijek J, Kijek J, Sphan CMT and Nierhaus HK (2014) (^#co-first author) EF-G and EF4: Translocation and back-translocation on the bacterial ribosome. Nat. Rev. Microbiol. (invited review)12 (2): 89-100

33.Zhang D and Qin Y* (2013) (*corresponding author) The Paradox of Elongation Factor 4: highly conserved yet of no physiological significance? Biochem. J. (invited review) 452 (2), 173-181

34.Li Z, Liu G, Guan H and Qin Y* (2013) (*corresponding author) Function study on conserved GTPase EF-G in protein synthesis. Acta. Biophysica. Sinica 29 (2): 105-117

35.Zhang D, Liu G, Xue J, Lou J, Nierhaus K H, Gong W* and Qin Y* (2012) (*corresponding author) Common chaperone activity in the G-domain of trGTPase protects L11–L12 interaction on the ribosome. Nucleic Acids Res. 40 (21): 10851-10865

36.Wang L, Yang F, Zhang D, Chen Z, Xu R, Nierhaus K H, Gong W and Qin Y* (2012) (*corresponding author) A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nat. Struct. Mol. Biol. 19(4): 403-410

37.Xie Q, Wang Y, Lin J, Qin Y, Wang Y and Bu W (2012) Potential Key Bases of Ribosomal RNA to Kingdom-Specific Spectra of Antibiotic Susceptibility and the Possible Archaeal Origin of Eukaryotes. PlosOne 7(1): e29468

38.Han B and Qin Y* (2012) (*corresponding author) Bioinformatics analysis reveals that LepA C-terminal domain is highly conserved in domain architectures and phylogenetic distribution. Science China: chemistry 42: 24-31

39.Wang X, Jiaying Xue, Zhe Sun, Qin Y* and Gong W* (2012) (*co-corresponding author) Study on the chaperone properties of conserved GTPases. Protein & Cell 3(1): 44-50

40.Xue J, Guan H and Qin Y* (2011) (*co-corresponding author) Chaperone Activity of Conservative GTPase ObgE. Acta. Biophysica. Sinica 27(6):1-12

41.Pech M, Karim Z, Yamamoto H, Kitakawa M, Qin Y and Nierhaus KH (2011) Elongation factor 4 (ef4/lepa) accelerates protein synthesis at increased Mg2+ concentrations. PNAS 108(8):3199-3203

42.Xie Q, Lin J, Qin Y, Zhou J, Bu W (2011) Structural diversity of eukaryotic 18S rRNA and its impact on alignment and phylogenetic reconstruction. Protein & Cell 2(2):161-17045.     

43.Xie Q, Tian X, Qin Y, Bu W (2009) Phylogenetic comparison of local length plasticity of the small subunit of nuclear rdnas among all hexapoda orders and the impact of hyper-length-variation on alignment. Mol. Phylogenet. Evol. 50(2):310-316.

44.Qin Y* (2008) (*co-corresponding author) Back-translocation in protein synthesis. Prog. Biochem. Biophys. 35(9):7

45.Connell SR^#, Topf M^#, Qin Y^#, Wilson DN, Mielke T, Fucini P, Nierhaus KH, Spahn CM (2008) (^#co-first author) A new trna intermediate revealed on the ribosome during ef4-mediated back-translocation. Nat. Struct. Mol. Biol. 15(9):910-915.

46.Di Giacco V^#, Marquez V^#, Qin Y^#, Pech M, Triana-Alonso FJ, Wilson DN, Nierhaus KH (2008) (#co-first author) Shine-dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG. PNAS 105(31): 10715-10720

47.Qin Y, Polacek N, Vesper O, Staub E, Einfeldt E, Wilson DN, Nierhaus KH (2006) The highly conserved lepa is a ribosomal elongation factor that back-translocates the ribosome. Cell 127(4):721-733.

l专利

1. Knud H Nierhaus, Yan Qin; Daniel Wilson. The protein factor LepA (EF4) as a new target for antibiotics against bacteria. PCT/EP 2007/008961

2. Yan Qin, Yanyan Gao. Usage of the mitochondrial translation factor Guf1 in Male sterility study. 2013104852275

1.       秦燕, 郝佳, 朱萍 “EF4蛋白编码基因沉默在癌症治疗方面的应用 20120566942.7” （申请号：201210566942.7，证书号 第2369805号）（已授权）

2.       秦燕, 高岩岩 线“粒体蛋白质翻译因子mtEF4/Guf1在雄性不育研究中的应用” （申请号201310485227.5 ，证书号 第1812912号）（已授权）

3. 秦燕，白秀峰  “用于毛发生长和诊断脱发生物标志物” （专利号：ZL2020 1 0024593.0证书号 第5390470号）（已授权）

4. 秦燕，赵遵岭，张娜，魏巍 “特发性肺纤维化诊断”（专利申请中）

5. 秦燕，孙立欣，黄卓越 “一种水凝胶及其制备方法和用途作为杀伤肿瘤核糖体的应用” （专利申请中）