办公室：新科技大楼645

职称：副教授      专业技术职务：副高

导师资格：学术&专业型博导/学术&专业型硕导

已培养硕士生人数（含正培养）：12

招生专业：生物医学工程专业（学术型）/药学专业（专业型）

电子邮件：bin.yang@gzhmu.edu.cn

单位：广州医科大学生物医学工程学院

【研究方向】

1. 开发医用高分子、无机纳米颗粒、功能多肽等生物医用材料

2. 探索光热治疗、光动力治疗、免疫治疗和化疗等新型联合干预策略

3. 开展抗肿瘤、抗菌、皮肤修复、心血管疾病、肾脏疾病等相关领域的应用

【教育经历】

【工作经历】

【学术任职兼职】

【近五年代表性科研/教学论文】

1. Liu Q#, Chen X#, Jiang Y, Yan M, Yu B, Zhang W, Cen Y, Zhang JY, Zhang J, Lei Q*, Li SY*, Yang B*. Self‐Promoted Targeting Delivery of Nanodrug Through Chemotherapeutic Upregulation of CD47 for Triple Negative Breast Cancer Therapy. Advanced Functional Materials 2023, DOI: 10.1002/adfm.202311677.

2. He PY#, Lei Q#, Yang B*, Shang TY, Shi JJ, Ouyang Q, Wang W, Xue LC, Kong FH, Li ZY, Huang JD, Liu LH, Guo JM, Brinker CJ, Liu KS*, Zhu W*. Dual-Stage irradiation of size-switchable albumin nanocluster for cascaded tumor enhanced penetration and photothermal therapy. ACS Nano 2022, 16(9), 13919-13932.

3. Deng FA, Yan MY, Liu YB, Wang RX, He HQ, Chen AL, Wang JJ, Xu L, Yang B*, Cheng H*, Li SY*. Self-delivery of metal-coordinated mitochondria protonophore uncoupler for O2-exhausting enhanced bioreductive therapy. Biomaterials 2022, 286, 121576.

4. Huang J#, Yang B#, Peng Y, Huang JS, Wong SHD, Bian LM, Zhu KS*, Shuai XT*, Han SS*. Nanomedicine-Boosting Tumor Immunogenicity for Enhanced Immunotherapy. Advanced Functional Materials 2021, 31(21), 2011171.

5. Shang T, Yu X, Gu Y, Du R, Cai YJ, Li YW, Zheng GD, Wang CQ, Zhang J, Liu JF*, Han SS*, Yang B*. Supermolecular nanovehicles co-delivering TLR7/8-agonist and anti-CD47 siRNA for enhanced tumor immunotherapy. International Journal of Biological Macromolecules, 2023, 251, 126539.

6. Cheng E, Li Y, Yuan W, Gong W, Cai Y, Gu Y, Jiang Y, Chen Y, Zhang J, Mo G*, Yang B*. Galvanostatic method assembled ZIFs nanostructure as novel nanozyme for the glucose oxidation and biosensing. Chinese Chemical Letters, 2023, DOI: 10.1016/j.cclet.2023.109386.

7. Gu Y, Cai Y, Kou Y, Cheng E, Bi H, Hu M, Wu S, Jiang Y, Zhang JX, Wu QT, Li YY*, Yang B*. Construction of multifunctional targeted nano-prodrugs based on PAMAM dendrimers for tumor therapy. European Polymer Journal, 2023, 200, 112486.

8. Mai Z, Cao N, Cheng E, Zeng Z, Feng Y, Wang Y*, French P, Lee YK, Yang H, Yang B*, Li H*, Zhou G. Self-Assembled Lenalidomide/AIE Prodrug Nanobomb for Tumor Imaging and Cancer Therapy. ACS Applied Nano Materials, 2023, 6 (21), 19807-19817.

9. Guo N, Xia Y, Duan YX, Wu QX, Xiao L, Shi YX, Yang B*, Liu Y*. Self-enhanced photothermal-chemodynamic antibacterial agents for synergistic anti-infective therapy. Chinese Chemical Letters 2023, 34(2), 107542.

10. Xu Y, Cai Y, Xia Y, Wu Q, Li M, Guo N, Tu Y*, Yang B*, Liu Y*. Photothermal nanoagent for anti-inflammation through macrophage repolarization following antibacterial therapy. European Polymer Journal, 2023, 186, 111840.

11. Yu XY, Shang TY, Zheng GD, Yang HL, Li YW, Cai YJ, Xie GX*, Yang B*. Metal-polyphenol-coordinated nanomedicines for Fe(II) catalyzed photoacoustic-imaging guided mild hyperthermia-assisted ferroustherapy against breast cancer. Chinese Chemical Letters 2022, 33(4), 1895-1900.

12. Zhang J, Qiu T, Lan Y, Tu C, Shang T, Lin Y, Mao G, Yang B*. Autocatalytic polymerization of selenium/polypyrrole nanocomposites as functional theranostic agents for multi-spectral photoacoustic imaging and photothermal therapy of tumor. Materials Today Chemistry 2020, 17, 100344.

13. Liu QY*, Yang D, Shang TY, Guo LX, Yang B*, Xu XJ*. Chain Conformation Transition Induced Host-guest Assembly between Triple Helical Curdlan and β-CD for Drug Delivery. Biomaterials Science 2020, 8, 1638-1648.

14. Shang T, Yu X, Han S, Yang B*. Nanomedicine-Based tumor photothermal therapy synergized immunotherapy. Biomaterials Science 2020, 8, 5241-5259.

15. Zheng GD, Zheng JH, Xiao L, Shang TY, Cai YJ, Li YW, Xu YM, Chen XM, Liu Y*, Yang B*. Construction of a Phenylboronic Acid-Functionalized Nano-Prodrug for pH-Responsive Emodin Delivery and Antibacterial Activity. ACS Omega 2021, 6, 8672-8679.

Xie YS, Tuguntaev RG, Mao C, Chen HT, Tao Y, Wang SX*, Yang B*, Guo WS*. Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy. Biophysics Reports 2020, 6, 193-210.

【授权专利】

【专著/学术译著】