办公室：科技楼602

职称：教授      专业技术职务：正高级

导师资格：学术&专业型博导

已培养硕/博士生人数：3/9

招生专业：生物医学工程、药学 

电子邮件：hzhang@gzhmu.edu.cn

单位：广州医科大学生物医学工程学院、附属第一医院

【研究方向】

1. 智能可编程纳米药物的构筑及对肿瘤和肥胖病的治疗；

2. 工程化细胞的合成生物学构建及其在类风湿性关节炎的治疗；

3. 工程化外泌体的构建及其对慢性肺部疾病的治疗

【教育和科研工作经历】

【人才称号】

【科研奖励】

【教学奖励】

【指导学生获奖】

【学术任职兼职】

【主持市级及以上科研/教学项目】

【代表性科研论文】

1. Yan, J.; Wang, Y.J.; Mu, Z.Z.; Han, X.Q.; Bi, L/P.; Wang, X.B.; Song, P.P.; Kang, Y.Q.; Wang, L.L; Zhang, X.Y.; Wang, Y.B.; Zhang, H.Y*. Gold Nanobipyramid-Mediated Apoptotic Camouflage of Adipocytes for Obesity Immunotherapy. Advanced Materials (IF=32.1) 2023, 35, 2207686

2. Cheng, Y.; Kong, X.P.; Chang, Y.; Gao, X.F.; Zhang, H.Y.*. Spatiotemporally Synchronous Oxygen Self-Supply and Reactive Oxygen Species Production on Z-Scheme Heterostructures for Hypoxic Tumor Therapy. Advanced Materials (IF=32.1) 2020, 32, 1908109.

3. Cheng, Y.; Chang, Y.; Feng, Y.; Jian, H.; Zhang, H.Y.*. Bismuth Sulfide Nanorods with Retractable Zinc Protoporphyrin Molecules for Suppressing Innate Antioxidant Defense System and Strengthening Phototherapeutic Effects. Advanced Materials (IF=32.1) 2019, 31, 1806808.

4. Cheng, Y.; Chang, Y.; Feng, Y.L.; Jian, H.; Tang, Z.H.; Zhang, H.Y.*. Deep-Level Defect Enhanced Photothermal Performance of Bismuth Sulfide-Gold Heterojunction Nanorods for Photothermal Therapy of Cancer Guided by Computed Tomography Imaging. Angewandte Chemie-International Edition (IF=16.8) 2018, 57, 246-251.

5. Zhang, H.Y.; Pokhrel, S.; Ji, Z.; Meng, H.; Wang, X.; Lin, S.; Chang, C.H.; Li, L.; Li, R.; Sun, B.; Wang, M.; Xia, T.; Maedler, L.; Nel, A.E.*. Pdo Doping Tunes Band-Gap Energy Levels As Well As Oxidative Stress Responses To A Co3O4 P-Type Semiconductor In Cells And The Lung. Journal of the American Chemical Society (IF=16.4) 2014, 136, 6406-6420.

6. Zhang, H.Y.; Dunphy, D.R.; Jiang, X.; Meng, H.; Sun, B.; Tarn, D.; Xue, M.; Wang, X.; Lin, S.; Ji, Z.; Garcia, F. L.; Kirk, M.L.; Xia, T.; Zink, J.I.; Nel, A.; Brinker, C.J.*. Processing Pathway Dependence Of Amorphous Silica Nanoparticle Toxicity: Colloidal Vs Pyrolytic. Journal of the American Chemical Society (IF=16.4) 2012, 134, 15790-15804.

7. Chang, Y; Cheng, Y.; Zheng, R.X.; Wu, X.Q; Song, P.P.; Wang, Y.J.; Yan, J.; Zhang, H.Y*. Plasmon-pyroelectric nanostructures used to produce a temperature-mediated reactive oxygen species for hypoxic tumor therapy. Nano Totay (IF=18.9) 2021, 38, 10110.

8. Han, X.Q.; Bi L.P.; Wu, Y.Y; Yan, J; Wu, X.Q.; Zheng, R.X.; Sun, Y.Y.; Zhang, H.; Wang, Z.X.;Wang, Y.B.; Zhang, H.Y.*. Genetically engineered exosomes for targetedly preventing premetastatic niche formation and suppressing postoperative melanoma lung metastasis. Nano Today (IF=18.9) 2022, 46, 101597.

9. Wang, L.; Chang, Y.; Feng, Y.; Li, X.; Cheng, Y.; Jian, H.; Ma, X.; Zheng, R.; Wu, X.; Xu, K.; Zhang, H.Y.*. Nitric Oxide Stimulated Programmable Drug Release of Nanosystem for Multidrug Resistance Cancer Therapy. Nano Letters (IF=12.3) 2019, 19, 6800.

10. Liu, X.; Feng, Y.; Xu, G.; Chen, Y.; Luo, Y.; Song, J.; Bao, Y.; Yang, J.; Yu, C.; Li, Y.; Ye, H.; Ke, B.; Chen, B.; Hu, J.; Xu, J.; Zhang, H.Y.*; Shi, H.B*, MAPK-Targeted Drug Delivered by a pH-Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-Cell Suppression. Advanced Functional Materials (IF=19.9) 2019, 0, 1806916.

11. Feng, Y.; Wang, G.; Chang, Y.; Cheng, Y.; Sun, B.; Wang, L.; Chen, C.; Zhang, H.Y.*, Electron Compensation Effect Suppressed Silver Ion Release and Contributed Safety of Au@Ag Core–Shell Nanoparticles. Nano Letters (IF=12.3) 2019, 19, 4478.

12. Chang, Y.; Feng, Y.; Cheng, Y.; Zheng, R.; Wu, X.; Jian, H.; Zhang, D.; Tang, Z.; Wang, Z.; Hao, J.; Zhang, H.Y.*, Anisotropic Plasmonic Metal Heterostructures as Theranostic Nanosystems for Near Infrared Light-Activated Fluorescence Amplification and Phototherapy. Advanced Science (IF=17.5) 2019, 6, 1900158.

13. Feng, Y.; Cheng, Y.; Chang, Y.; Jian, H.; Zheng, R.; Wu, X.; Xu, K.; Wang, L.; Ma, X.; Li, X.; Zhang, H.Y.*, Time-staggered delivery of erlotinib and doxorubicin by gold nanocages with two smart polymers for reprogrammable release and synergistic with photothermal therapy. Biomaterials (IF=15.3) 2019, 217, 119327.

14. Chang, Y.; Cheng, Y.; Feng, Y. L.; Li, X.*; Zhang, H.Y.*, Resonance Energy Transfer-Promoted Photothermal and Photodynamic Performance of Gold- Copper Sulfide Yolk-Shell Nanoparticles for Chemophototherapy of Cancer. Nano Letters (IF=12.3) 2018, 18, 886-897.

15. Liu, N.; Li, K.; Li, X.; Chang, Y.; Feng, Y. L.; Sun, X. J.; Cheng, Y.; Wu, Z. J.*; Zhang, H. Y.*, Crystallographic Facet-Induced Toxicological Responses By Faceted Titanium Dioxide Nanocrystals. ACS Nano (IF=18.0) 2016, 10, 6062-6073.

16. Cheng, Y.; Chang, Y.; Feng, Y. L.; Liu, N.; Sun, X. J.; Feng, Y. Q.; Li, X.*; Zhang, H.Y.*, Simulated Sunlight-Mediated Photodynamic Therapy for Melanoma Skin Cancer by Titanium-Dioxide-Nanoparticle-Gold-Nanocluster-GrapheneHeterogeneous Nanocomposites. Small (IF=15.2) 2017, 13, 1603935.

17. Zhang, H. Y.; Ji, Z.; Xia, T.; Meng, H.; Low-Kam, C.; Liu, R.; Pokhrel, S.; Lin, S.; Wang, X.; Rallo, R.; Damoiseaux, R.; Telesca, D.; Maedler, L.; Cohen, Y.; Zink, J. I.; Nel, A. E.*, Use Of Metal Oxide Nanoparticle Band Gap To Develop A Predictive Paradigm For Oxidative Stress And Acute Pulmonary Inflammation. ACS Nano (IF=18.0) 2012, 6, 4349-4368.

18. Zhang, H. Y.; Xia, T.; Meng, H.; Xue, M.; George, S.; Ji, Z.; France, B.; Rallo, R.; Damoiseaux, R.; Cohen, Y.; Bradley, K. A.; Zink, J. I.; Nel, A. E.*, Differential Expression Of Syndecan-1 Mediates Cationic Nanoparticle Toxicity In Undifferentiated Versus Differentiated Normal Human Bronchial Epithelial Cells. ACS Nano (IF=18.0) 2011, 5, 2756-2769.

【授权专利】