
向之明博士研究生导师(学术型/专业型博士研究生导师)
【个人简介】
医学博士,主任医师,教授,博士研究生导师、博士后指导导师。美国USC博士后访问学者,现任广州医科大学附属番禺中心医院副院长、影像科学科带头人、影像研究所所长。 目前培养指导博士后、博士、硕士研究生50余人。
【研究方向】
肿瘤多模态影像诊断及肿瘤多组学解析机制研究
【科研项目】
(1) 国家自然科学基金委员会,面上项目,82171931,基于影像组学联合“微生物-宿主”多组学的肺腺癌早期诊断模型及机制研究,主持;
(2) 国家自然科学基金委员会,面上项目,81671853,基于多模态影像多维度直方图特征的肝硬化结节早期癌变微循环构建研究,主持;
(3) 广东省基础与应用基础研究基金,2025A1515220105,基于影像组学与微生态多组学联合分析的肺腺癌免疫微环境调控机制及治疗响应预测研究,主持;
(4) 广东省自然科学基金委员会,自由申请,2015A030313753,采用心电门控技术克服心脏搏动对肝脏DWI影响的相关研究,主持;
(5) 广州市科学技术局,民生科技项目,201903010032,基于多模态MR的肝硬化结节早期癌变人工智能辅助分析,主持;
(6) 广州市番禺科技局重大项目,基于云计算技术的番禺区医联体区域影像医学诊断平台构建与应用示范,主持;
(7) 广州市医学影像重点学科建设项目,广州市卫健委,主持。
(8)广东省肺结节诊疗全周期人工智能工程技术研究中心,广东省科技厅,主持。
【代表性论文及著作】
(1)Ketogenic Diet Alleviates Septic Lung Injury via Microbial Gut-Lung Axis,Cell Metabolism,2026 Mar 3;38(3):493-511;
(2)Dynamic microbiome-host interactions and their associations with systemic metabolism and radiological characteristics during early lung adenocarcinoma. Npj precision oncology,2026
(3)Bio-interpretable ensemble learning model for invasive pulmonary adenocarcinoma grade using CT and histopathology images.Npj precision oncology.
(4)Feasibility of BMI-based sub-milliSievert low-dose CT in individualized detection of
lung nodules.European Radiology,2026.
(5)Microbiome-host interactions in different pathomic subtypes of early-stage lung adenocarcinoma. BMC Pulm Med. 2026 Jun 25;26(1):404.
(6)PTM-Related Signatures Predict Lymph Node Metastasis and Shape Microenvironment in Hepatocellular Carcinoma: A Single-Cell and Bulk Integrated Analysis. J Hepatocell Carcinoma. 2026 Jul 29;13:607916.
(7)Integrating CT Radiomics and Machine Learning for Preoperative Assessment of STAS Grading and Prognostic Stratification in Lung Adenocarcinoma. Academic Radiology,2026
(8)Respiratory microbiome-host interaction on lung carcinogenesis, immunity, and immunotherapy. Frontiers in Immunology. 2025 Nov 28;16:1676302.
(9)Chronic hypoxia promotes pulmonary venous smooth muscle cell proliferation through the CaSR-TRPC6/ROCE pathway,Experimental Cell Research,2025 Jan 15;444(2):114363.
(10)Artificial intelligence-assisted surgical simulation system based on non-enhanced computed tomography images in thoracoscopic pulmonary segmentectomies, Journal of Thoracic Disease,2025 Aug 31;17(8)doi: 10.21037/jtd-2025-375.
(11)Prediction of lymph node metastasis in lung adenocarcinoma using a PET/CT radiomics-based ensemble learning model and its pathological basis,Frontiers in Oncology,2025.
(12)Quantitative Evaluation of Microenvironmental Changes and Efficacy of Cupping Therapy under Different Pressures Based on Photoacoustic Imaging.Photoacoustics,2024(40),100601.
(13)CIEC: Cross-tissue Immune Cell Type Enrichment and Expression Map Visualization for Cancer.Genomics, Proteomics & Bioinformatics,2024.
(14) Prognostication of colorectal cancer liver metastasis by CE-based radiomics and machine learning.Translational Oncology,2024 Sep:47:101997
(15) A CT-Based Radiomics Nomogram Combined with Clinic-Radiological Characteristics for Preoperative Prediction of the Novel IASLC Grading of Invasive Pulmonary Adenocarcinoma.Academic Radiology,2023 Sep;30(9):1946-1961.
(16) Clinical Value of Deep Learning Image Reconstruction on the Diagnosis of Pulmonary Nodule for Ultra-low-dose Chest CT Imaging. Clinical Radiology,2024 Aug;79(8):628-636.
(17)The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans.Nature Medicine,2023 Jul;29(7):1750-1759.
【所获荣誉和奖励】
广州市优秀人才、广州市番禺区十大领军人物、岭南名医等。
【学术兼职】
广东省医学会肿瘤影像与大数据分会副主任委员、广东省医院协会影像专业委员会副主任委员、广东省医疗行业协会影像管理委员会副主任委员、广东省医学教育学会放射影像专委会副主任委员、广州市医师协会放射医师分会副主任委员、广州市医师协会副会长。