【个人简介】
曹莉萍，医学博士，主任医师，博士研究生导师，广州医科大学附属脑科医院早期干预科和儿少科学科带头人。华西医科大学本科毕业，后续师从老一辈著名精神病学家刘协和教授，获医学博士学位。2014-2015耶鲁大学医学院遗传学系访问学者。兼任中国优生科学协会妇女儿童心理健康分会常委，广东省医学会精神病学分会常委、儿童精神医学组组长。获“中国杰出精神科医师”称号，入选广州市高层次人才。在国内率先建立和推广精神障碍的早期整合干预模式，并成立华南精神心理早期干预联盟。同时，致力于青少年抑郁障碍和双相障碍的早期诊疗标记和遗传病因学研究，主持科技部重点研发计划子课题（1项）、国家自然科学基金面上项目（2项）等。作为中国脑计划抑郁症项目分中心负责人，已建立颇有规模的国际一流的青少年抑郁障碍sBEAD队列，并开展前沿领域多学科交叉的国内外研究合作。发表论著50余篇。
【研究方向】
儿童青少年精神医学；青少年抑郁障碍和双相障碍的早期诊疗标记、早期干预和遗传学病因。
【科研项目】
1.2024年度广州市科技计划项目：通过外泌体探索青少年抑郁障碍的大脑脂质代谢异常（2024A03J0298）,资助50万，起止日期：2024-01-01至2025-12-31。主持。
2.2024年度广东省基础与应用基础研究基金自然科学基金面上项目：膜脂调控蛋白SERINC2参与双相障碍发病的小脑特定神经细胞亚群定位及分子机制研究（2024A1515010705）。资助15万元。起止日期：2024.01-2026.12。主持。
3.国家自然科学基金面上项目：膜脂调控蛋白SERINC2参与双相障碍发病的特定神经细胞亚群定位及分子机制研究，项目批准号：82371538，直接费用：49.00万元，项目起止年月：2024.01-2027.12；主持。
4.科技创新2030-“脑科学与类脑研究”重大项目：抑郁症的发病机制及干预技术研究项目（2022ZD0211700）。资助5953.47万。课题1：抑郁症生物和环境危险因素研究（2022ZD0211701），资助1788.50万元.分中心负责人，资助400万。起止日期：2022.8-2027.7。
5.国家自然科学基金面上项目：膜脂调控蛋白Serinc2罕见突变在双相障碍家系发病中的作用和机制，项目批准号：81771466，直接费用：54.00万元，项目起止年月：2018.01-2021.12；主持，已结题。
【代表性论文及著作】
1. Xiaofang Cheng, Zhuozhi Dai, Jianshan Chen, XiaofeiZhang, Jiaqi Sun, Ruilan Yang, Amei Chen,Zhuoyong Cheng, Tianhe Pan, Ziyi Song, Qiuxia Wu, Haishan Wu, Xiuling Wu, Yanlong Jia, Yingmei Chen, Daomeng Cheng, Yanling Zhou, Biyu Ye, Xuan Li, Chanjuan Yang, Xinhua Weib, Liping Cao*.(in press). Sex-specific role of systemic inflammation in moderating the associationbetween choroid plexus volume and depressive severity: findings from sBEAD. Biological Psychiatry.
2. Ruilan Yang, Jianshan Chen, Tianlang Ke, Xiaofei Zhang, Xiaofang Cheng, Qiuxia Wu, Jiaqi Sun, Wenhao Deng, Xiongchao Cheng, Wenjin Zou, Yizhi Zhang, Chanjuan Yang, Liqian Cui, Biyu Ye, Xuan Li*, Liping Cao*. (2026). Influence of BDNF rs10835210 on right parahippocampal volume and its related cognitive function in first- and multiple-episode bipolar disorder. BMC Psychiatry. doi:10.1186/s12888-026-07949-7.
3． Chenxi Wang, Xiaofei Zhang, Jiaqi Sun, Ziyuan Zhang, Ze Liang, Zhuliang Yu, Jian Yang, Dongrong Zhao, Xin Qi, Qilong Wang, Yongfeng Dai, Liping Cao*, Xinhong Zhu*. (2026). Detection of major depressive disorder in adolescents based on textual and acoustic features. Journal of Affective Disorders, 396:120795. doi:10.1016/j.jad.2025.120795. 4． YingHan Wang, ChongLei Fu, LinBo Chen, ChuYi Zhang, JianShan Chen, QiaoMing Zhang, Yirui Liang, RuiLan Yang, Yu Li, YaNi Zhang, YiNuo Han, ZhenLiang Yuan, YiNi Chen, Haimei Li, Yanmeng Pan, Shaohua Hu, Ming Li*, LiPing Cao*, Jun Yao*. (2025). Microglia contribute to bipolar depression through Serinc2-dependent phospholipid synthesis. Proceedings of the National Academy of Sciences, 122(37):e2500116122. doi:10.1073/pnas.2500116122.4． Xiaofei Zhang, Tao Lin, Guanjie Zhang, Jianshan Chen, Xichao Wang, Wanheng Zhang, Xiaoqing Zhang, Jiaqi Sun, Weiming Li, Yutong Liu, Xuanlin Zeng, Lei Chen, Yimiao Mao, Biyu Ye, Yanling Zhou, Xuan Li, Chanjuan Yang, Liping Cao*, Yuping Ning*. (2025). Hippocampal Volume Reductions in Key Regions and Their Role in Disease Progression in Adolescents at High Risk for Bipolar Disorder: Findings From the sBEAD Cohort. Bipolar Disorders, 27(3):232-245. doi:10.1111/bdi.70014.5． Jing Wang, Jianshan Chen, Junle Li, Qiuxia Wu, Jiaqi Sun, Xiaofei Zhang, Xuan Li, Chanjuan Yang, Liping Cao*, Jinhui Wang*. (2025). Transdiagnostic network alterations and associated neurotransmitter signatures across major psychiatric disorders in adolescents: Evidence from edge-centric analysis of time-varying functional brain networks. Journal of Affective Disorders, 380:401-412. doi:10.1016/j.jad.2025.03.151.6． YaoNan Liu, QiuWen Wang, XinYu She, LiJun Li, Bing Wang, Ruilan Yang, Qian Li, SiYao Lu, YingHan Wang, Wei Shen, ChongLei Fu, Dan Li, Lan Yi, ChunXue Wang, Wei Shi, Xin Cheng, Liping Cao, Shuangli Mi, Jun Yao*. (2025). A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors. Nature Neuroscience. doi:10.1038/s41593-025-02040-y.7． Xiaofei Zhang, Yanling Zhou, Jiaqi Sun, Ruilan Yang, Jianshan Chen, Xiaofang Cheng, Zezhi Li, Xinlei Chen, Chanjuan Yang, Xinhong Zhu, Liping Cao*. (2022). A cohort study of adolescents with depression in China: tracking multidimensional outcomes and early biomarkers for intervention. General Psychiatry, 35(4):e100782. doi:10.1136/gpsych-2022-100782.
