【个人简介】
医学博士，研究员、副主任医师、博士生导师、博士后合作导师，美国约翰霍普金斯大学访问学者，广州医科大学南山学者。现任广州医科大学附属第二医院眼科主任、教研室主任。
先后就职于中山大学中山眼科中心、广东省人民医院。擅长白内障、葡萄膜炎、玻璃体视网膜疾病的诊治。
主持国家自然科学基金3项，省市厅级课题9项。发表学术论文60余篇，其中以第一或通讯作者发表 SCI 论文30余篇，参编著作3部，授权专利3项；参与制定专家共识3项、规范1部。兼任中国医师协会眼科医师分会葡萄膜炎与免疫专委会委员、中国女医师协会眼科专委会委员、中国老年保健医学研究会眼科疾病防治分会委员、广东省眼健康协会中老年眼保健专委会主任委员、广东省预防医学会眼底疾病防治专委会常委、广东省医学会眼科学分会委员、广东省医师协会眼科医师分会委员等。
【研究方向】
眼科学；
1.葡萄膜炎及眼免疫性疾病
2.玻璃体视网膜疾病
【科研项目】
1. 国家自然科学基金面上项目（82171072），HIF-1α/CKAP2正反馈诱导病理性视网膜新生血管的作用机制研究，2022.01-2025.12，57万元，主持，结题
【代表性论文及著作】
(1) Chen D, Wu G, Liao S, Zhu H, Li F, Liu C, Zhao H, Meng Q*, Fang X*. Machine learning-driven identification of circulating biomarkers and therapeutic compounds for diabetic retinopathy. Hum Genomics. 2026 May 14. doi: 10.1186/s40246-026-00967-2. Online ahead of print.
(2) Zhu HX, Li FF, Chen XM, Zhang BY, Xu T, Lian ZX*, Gao CY*, Meng QL*. Single-cell profiling reveals clonal CD8+T cell-derived IFNγ drives Sjögren's disease-related dacryoadenitis. Inflamm Res. 20263;75(1):166
(3) Wu X, Liu J, Zhu H, Wu G, Chen X, Guo T, Fang X*, Meng Q*. FoxO1, together with Notch1, promotes microglial activation to induce pathological changes in the retinal vasculature under hypoxia. Cell Mol Life Sci. 2025;83(1):12.
(4) Jin Y, Liu J, Zhang X, Zhang L, Cui Y, Luo X, Zhu H, Chen Z, Liu M, Wu X, Chen X, Liao S, Wu G, Fang X*, Meng Q*. Stage-dependent proteomic alterations in aqueous humor of diabetic retinopathy patients based on data-independent acquisition and parallel reaction monitoring. J Transl Med. 2025;23(1):476.
(5) Chen Z, Liao S, Chen G, Li C, Liu C, Liu J, Wu G, Lyu Z, Liu M, Wu X, Ma G*, Meng Q*. The Combination of Retinal Neurovascular Unit Changes with Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke. Transl Vis Sci Technol. 2025;14(3):14.
(6) Li X, Wen X, Shang X, Liu J, Zhang L, Cui Y, Luo X, Zhang G, Xie J, Huang T, Chen Z, Lyu Z, Wu X, Lan Y*, Meng Q*. Identification of diabetic retinopathy classification using machine learning algorithms on clinical data and optical coherence tomography angiography. Eye (Lond). 2024;38(14):2813-2821.
(7) Lyu Z, Chen Y, Zhu Z, Luo X, Cui Y, Xie J, Chen Z, Liu J, Wu X, Bulloch G, Meng Q*. Associations of concomitant retinopathy and depression with mortality in a nationally representative population. J Affect Disord. 2023; 336:15-24.
(8) Chen X, Xie J, Cui Y, Zhang L, Yu H, Chen J, He M, Liu S, Huang T, Chen L, Fang D, Zhu Y, Zhang S*, Meng Q*. Cytoskeleton-associated protein 2 (CKAP2) is regulated by vascular endothelial growth factor and p53 in retinal capillary endothelial cells under high-glucose conditions. Mol Cell Endocrinol. 2021; 111378.
(9) Xie J, Cui Y, Chen X, Yu H, Chen J, Huang T, He M, Zhang L*, Meng Q*. VDAC1 regulates mitophagy in NLRP3 inflammasome activation in retinal capillary endothelial cells under high-glucose conditions. Exp Eye Res. 2021; 209:108640.
(10) Li X, Xie J, Zhang L, Cui Y, Zhang G, Chen X, Wang J, Zhang A, Huang T, Meng Q*. Identifying microvascular and neural parameters related to the severity of diabetic retinopathy using optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2020; 61(5):39.
【所获荣誉和奖励】
1. 2010年 教育部科技进步二等奖
2. 2011年 广州市首批珠江科技新星
3. 2023年 广东省科技进步二等奖
