张玉霞，博士生导师，广州医科大学附属市妇女儿童医疗中心教授。广东省“珠江学者”特聘教授（儿科学），获国家自然科学基金面上、重大研究计划培育和集成项目资助，2021年获得国家杰出青年科学基金。从事儿童免疫相关疾病的发生机制、遗传易感因素以及防治策略研究，先后阐述了儿童肠-肝免疫失稳态的分子遗传机制，开发了疾病的早期预警系统，开创了利用PDE抑制剂治疗儿童肠道炎症性疾病，以及利用B细胞清除疗法治疗新生儿胆道闭锁的新用途。

主要研究方向：1.儿童慢病的区域免疫发病机制；2.感染免疫；3.免疫缺陷与自身炎症。

招生专业：生物化学与分子生物学（071009）；细胞生物学（071010）。

邮箱：yuxia.zhang@gwcmc.org

代表性论文

1.Wang, J.*, Xu, Y.*, Chen, Z.*, Liang, J.*, Lin, Z.*, Liang, H.*, Xu, Y., Wu, Q., …, Lu, L., Bai, F.^#, Xia, H.^#, Wen, Z.^#, andZhang, Y.^#(2020). Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia.Cell.

2.Huang, B.*, Chen, Z.*, Geng, L.*, Wang, J.*, Liang, H., Cao, Y., Chen, H., ...., Zhang, Y., Gong, S.^#, Bai, F.^#, Yang, M.^#, andZhang, Y.^#(2019). Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways.Cell179, 1160-1176 e1124.

3.Zhang, Y.*^#, Collier, F., Naselli, G., Saffery, R., Tang, M.L., Allen, K.J., Ponsonby, A.L., Harrison, L.C.^#, Vuillermin, P.^#, and Group, B.I.S.I. (2016). Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "T(H)2-type" immunity associated with development of food allergy.Sci Transl Med8, 321ra328.

4.Zhang Y, Kinkel S, Maksimovic J, Bandala-Sanchez E, Tanzer MC, Naselli G, Zhang JG, Zhan Y, Lew AM, Silke J, Oshlack A, Blewitt ME, Harrison LC. The polycomb repressive complex 2 governs life and death of peripheral T cells.Blood. 2014 Jul 31;124(5):737-49.

5.Zhang Y, Maksimovic J, Naselli G, Qian J, Chopin M, Blewitt ME, Oshlack A, Harrison LC. Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells.Blood. 2013 Oct 17;122(16):2823-36.

6.Bandala-Sanchez E*,Zhang Y*, Reinwald S, Dromey JA, Lee BH, Qian J, Böhmer RM, Harrison LC. T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10.Nat Immunol. 2013 Jul;14(7):741-8.