周忠诚，博士，广州医科大学附属妇女儿童医疗中心副研究员、本科生导师、硕士生导师。本科毕业于吉林大学，2018年于南开大学获得博士学位，2018年8月加入广州医科大学附属妇女儿童医疗中心，历任研究助理、研究主管和副研究员。现主要从事表观遗传调控早期发育和胚胎干细胞中的功能和机制、以及利用单细胞多组学和基因编辑技术研究唐氏综合症的致病分子机制。迄今已在Nucleic Acids Research 、 STTT、Journal of Medical Virology、MedComm 、Gene等杂志发表多篇论文，主持国家自然科学基金青年项目和广州市青年博士“启航”项目、参与国家自然科学基金面上项目。

联系方式：zhouzhongcheng@gwcmc.org

代表性文章如下：

1.Li G^#, Zhou Z^#, Du P^#, Zhan M^#, Li N, Xiong X, Tang S, Man M, Basptista-Hon D, Lu L. Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant. Signal Transduct Target Ther. 2022. Jul 19; 7(1):243. doi:10.1038/s41392-022-01062-3

2.Zhou Z^#, Du P^#, Yu M, Baptista-Hon D, Miao M, Xiang P, Lau J, Li G, Zhang K. Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant, CAL.20C. Signal Transduct Target Ther. 2021 Jul 27;6(1):285.

3.Du P, Li N, Xiong X, Tang S, Dai Q, Liu Z, Wang T, Gu X^*, Zhou Z^*. A bivalent vaccine containing D614G and BA.1 spike trimer proteins or a BA.1 spike trimer protein booster shows broad neutralizing immunity. J Med Virol. 2022 Sep; 94(9):4287-4293. doi:10.1002/jmv.27885.

4.Zhou Z, Wang L, Ge F, Gong P, Wang H, Wang F, Chen L, Liu L. Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res. 2018 Apr 20;46(7):3468-3486

5.Zhou Z^#, Du P^#, Li N^#, Xiong X^#, Tang S, Dai Q, Wang T, Yu M, Man M, Lam K, Basptista-Hon D, Tai W, Monteiro O, Ng W, Lee U, Liu Z, Zhang K, Li G. Homologous or heterogenous vaccination boosters enhance neutralizing activities against SARS-CoV-2 Omicron BA.1 variant. MedComm. 2022 May 11;3(2):e143.doi:10.1002/mco2.143.

6.Hong H^#, Zhou Z^#, Xiong X, Liu Z, Zheng X, Quan Q, Yu M. SARS-CoV-2 Delta (B.1.627.2) Spike protein adjuvanted with Alumn-3M-052 enhances antibody production and neutralization ability. Front Public Health. 2023 Jan 6;10:976686. doi: 10.3389/fpubh.2022.976686

7.Li G^#, Zhou Z^#, Du P^#, Yu M, Li N, Xiong X, Huang H, Liu Z, Dai Q, Zhang C, Zhang E, Song H, Baptista-Hon D, Miao M, Lau J, Xiang P, Zhang K. The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera. Precis Clin Med. 2021 Jul 30: pbab016

8.Gu X^#, Dai Q^#, Du P^#, Li N, Li J, Zeng S, Peng S, Tang S, Wang L, Zhou Z. Pold4 is dispensable for mouse development, DNA replication and DNA repair. Gene. 2023 Jan 30;851:147029. Epub 2022 Nov 7. doi:10.1016/j.gene.2022.147029.

9.Wang Y, Wang P, Zhang Y, Xu J, Li Z, Li Z, Zhou Z, Liu L, Cao X. Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation. Immunity. 2020 Dec 15;53(6):1168-1181.e7.

10.Guo R, Yang J, Ye X, Zhou Z, Wang H, Wang H, Fu H, Tian C, Zeng M, Yang J, Liu L. Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells. Nat Commun. 2018. Jul 5;9(1):2620.

11.Liu N, Yin Y, Wang H, Zhou Z, Sheng X, Fu H, Guo R, Wang H, Yang J, Gong P, Ning W, Ju Z, Liu Y, Liu L. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling. PLoS Genet. 2019 Sep 13;15(9):e1008368.

12.Yang J, Guo R, Wang H, Ye X, Zhou Z, Dan J, Wang H, Gong P, Deng W, Yin Y, Mao S, Wang L, Ding J, Li J, Keefe DL, Dawlaty MM, Wang J, Xu G, Liu L. Tet enzymes regulate telomere maintenance and chromosomal stability of mouse ESCs. Cell Rep. 2016 May 24;15(8):1809-21.