【个人简介】
朱明伟，生物化学与分子生物学博士，副研究员，硕士/博士生导师。2010年博士毕业于上海交通大学，2011-2017年在美国路易斯安那州立大学健康科学中心进行博士后培训。2018年回国，加入广州医科大学附属妇女儿童医疗中心儿科研究所。
【研究方向】
1. 罕见遗传疾病的诊断、发病机制及治疗研究
2. 孤独症发病机制研究
【科研项目】
1. 国家自然科学基金面上项目，81972038，2020/01-2023/12，主持，结题
2. 国家自然科学基金地区项目，82360225，2024/01-2027/12，主持，在研
3. 国家科技部“脑科学与类脑研究”重大项目，2021ZD0200522，2021/12-2026/11，子任务负责人，在研
4. 广东省自然科学基金面上项目，2023A1515010281，2023/01-2025/12，主持，在研
5. 广东省自然科学基金面上项目，2022A1515012506，2022/01-2024/12，主持，在研
6. 广州市基础与应用基础研究项目，202201010838，2022/04-2024/03，主持，结题
7. 广东省“脑科学与类脑研究”重点领域研发计划，2018B030335001， 2019/01-2022/12，参加，结题
8. 广州市重点领域研发计划，202007030002，2020/04-2023/03，参加，结题
【代表性论文及著作】(#第一作者；*通讯作者)
1. Tianying Nong#, Jiangui Li#, Xia Li#, Yiqiang Li, Zhaohui Li, Weizhe Shi, Qiuchan Zhou, Hongwen Xu*, Mingwei Zhu*, Ya-Ping Tang*. The mucolipidosis III-causing mutation in GNPTAB, c.1760G>C, disrupts the development of somites in rats, Genes & Diseases, 2024, 11(6):101172.
2. Yongyi Li#, Mingwei Zhu#, Wen-Xiong Chen#, Jing Luo, Xin Li, Yangyang Cao, Meng Zheng, Shanshan Ma, Zhilan Xiao, Yani Zhang, Linyan Jiang, Xiumin Wang, Ting Tan, Xia Li, Qian Gong, Xiaoli Xiong, Jun Wang, Mingxi Tang*, Mingtao Li*, Ya-Ping Tang*. A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats, Molecular Psychiatry, 2023, 28(9):3795-3805.
3. Xuping Jing#, Mingwei Zhu#, Xiaoyun Lu#, Ping Wei, Lingyu Shi, Bu-Yun Zhang, Yi Xu, Ya-Ping Tang*, Dao-Man Xiang*, Peng Gong*. Cataract-causing Y204X mutation of CRYBB1 promotes C-terminal degradation and higher-order oligomerization, Journal of Biological Chemistry，2023，299(8):104953
4. Ping Wei#, Weizhe Shi#, Tianying Nong#, Caixia Xian, Xia Li, Zhaohui Li, Xin Li, Jianping Wu, Liyuan Shang, Fulong Xu, Yibo Xu, Hongwen Xu*, Mingwei Zhu*. Novel de novo TRPV4 mutation identified in a Chinese family with metatropic dysplasia inhibits chondrogenic differentiation, Genes & Diseases, 2023, doi: 10.1016/j.gendis.2023.05.008
5. Xuying Tan#, Ting Zhang#, Xuejiao Ding, Xiaopeng Zhao, Qianjun Liu, Zhenglong Xia, Qihua Cao, Feng Yan, Li Chen, Mingwei Zhu*, Ya-Ping Tang*, Yanyan Song*. Iron overload facilitated neonatal hypoxic-ischemia brain damage via SLC7A11-mediated ferroptosis, Journal of Neuroscience Research, 2023, 101(7):1107-1124
6. Daniel Martinez#, Mingwei Zhu#, Jessie J. Guidry, Niles Majeste, Hui Mao, Sarah Yanofsky, Xiaolin Tian* and Chunlai Wu. Mask, the Drosophila Ankyrin Repeat and KH domain-containing protein, affects microtubule stability, Journal of Cell Science, 2021, 134(20):jcs258512.
7. Caixia Xian#, Mingwei Zhu#*, Tianying Nong, Yiqiang Li, Xingmei Xie, Jiangui Li, Jingchun Li, Jianping Wu, Weizhe Shi, Ping Wei, Hongwen Xu, Ya-Ping Tang. A novel mutation in ext2 caused hereditary multiple exostoses through reducing the synthesis of heparin sulfate, Genetics and Molecular Biology, 2021, 44(2): e20200334.
8. Mingwei Zhu, Sheng Zhang, XiaolinTian*, Chunlai Wu*, Mask mitigates Tau- and FUS-induced degeneration by enhancing autophagy through lysosomal acidification, Autophagy, 2017, 13(11): 1924-1938.
9. Mingwei Zhu, Xia Li, XiaolinTian*, Chunlai Wu*, Mask loss of function recues mitochondrial impairment and muscle degeneration of Drosophila Pink1 and Parkin mutants, Human Molecular Genetics, 2015, 24(11): 3272-3285.
10. Mingwei Zhu#, Tianchi Xin#, ShunyanWeng, Yin Gao, Yingjie Zhang, Qi Li, Mingfa Li. Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs, Cell Research, 2010, 20(2): 242-245
【所获荣誉和奖励】
2024年荣获广州市卫生健康委优秀人才称号
