【个人简介】

【研究方向】

成体干细胞的命运决定调控；表观遗传调控；再生及衰老的调控。

【科研项目】

【代表性论文及著作】

1.Profound cellular defects attribute to muscular pathogenesis in rhesus monkey model of Duchenne muscular dystrophy. Shuaiwei Ren,1,2,3,11 Xin Fu,4,11, Wenting Guo,1,3,11 Raoxian Bai,1,2,3,11 Sheng Li,4 Ting Zhang,1,3,10 Jie Liu,1,3 Zhengbo Wang,1,3 Hui Zhao,5,6 Shengbao Suo,5 Weikang Zhang,8 Minzhi Jia,9 Weizhi Ji,1,3,* Ping Hu,4,5,6,7,* and Yongchang Chen1,2,3,10,12,* Cell, accepted on Aug. 4.

2.Human myogenic progenitor cells display tenogenic differentiation potential and facilitate tendon regeneration. Xiexiang Shao, Xingzuan Lin, Hao Zhou, Lili Han, Xin Fu, Sheng Li, Siyuan Zhu, Shenao Zhou, Jianhua Wang*, and Ping Hu*. eLife, 2024. https://doi.org/107554/eLife.98636.1.sa4

3.Using Cleavage Under Targets and Tagmentation (CUT&Tag) Assay in Mouse Myoblast Research, Yuefeng Li, Xiaofen Wu, and Ping Hu*. Journal of Visual Experiments (J. Vis Exp., JOVE). 2024 Mar 1:(205). doi: 10.3791/66066.

4.Gli1 marks a sentinel muscle stem cell population for muscle regeneration. Jiayin Peng, Lili Han, Biao Liu, Song J, Wang Y, Wang K, Guo Q, Liu X, Li Y, Zhang J, Wu W, Li S, Fu X, Zhuang CL, Zhang W, Suo S, Ping Hu*, Yun Zhao*. Nat Commun. 2023 Nov 1;14(1):6993. doi: 10.1038/s41467-023-42837-8.

5.Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells. He Jax Xu, Yao Yao, Fengyong Yao, Jiehui Chen, Meishi Li, Xianfa Yang, Sheng Li, Fangru Lu, Ping Hu, Shuijin He*, Guangdun Peng*, Naihe Jing*. 2023, Mar 23;12(1):15. doi: 10.1186/s13619-023-00159-6.

6.Asymmetrical Inactivation of ESR1 Signaling in Muscle Progenitor Cells Causes and its Reactivation Alleviates Progression of Adolescent Idiopathies Scoliosis. Xiexiang Shao#, Xin Fu#, Wenyuan Sui, Wenjun Yang, Xingzuan Lin, Zifang Huang, Sheng Li, Minzhi Jia, Huan Liu, Wei Liu, Lili Han, Yang Yu, Yaolong Deng, Tianyuan Zhang, Jingfan Yang, and Junlin Yang*, and Ping Hu*. Cell Discovery, 2023, Jan. 30.

7.Chemical reprogramming of melanocytes to skeletal muscle cells. Wenjun Yang*, Yaqi Wang*, Yuanyuan Du*, Jiyong Li, Sheng Li, Cheng Li, Hongkui Deng*, and Ping Hu*. Journal of Cachexia, Sarcopenia and Muscle. 2023 Feb 1. doi: 10.1002/jcsm.13155.

8.Regulation of the muscle stem cell fate. Xin Fu, Cheng-le Zhuang, Ping Hu*. Cell Regeneration. 2022, Dec. 11:40.

9.Myogenesis controlled by a long non-coding RNA 1700113A16RIK and post-transcriptional regulation. Wenjun Yang, Lele Yang, and Ping Hu*. Cell Regeneration, 2022

10.RNA binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling. Jinlong Suo, Sihai Zou, Chenchen Lv, Yujiao Han, Lingli Zhang, Jinghui Wang, Bo Jiang, Qian Ren, Long Chen, Lele Yang, Ping Ji, Xianyou Zheng, Ping Hu*, and Weiguo Zou*. Bone Research, 2022, Mar 17;10(1):31.

11.Msi2 mediated MiR7a-1 processing repression promotes myogenesis. Wenjun Yang*, Lele Yang*, Jianhua Wang*, Lili Han, Sheng Li, Qi Yin，Ruimiao Ma, Jinsong Li,Jingyi Hui*, and Ping Hu*. Journal of Cachexia, Sarcopenia and Muscle. 2022 Feb;13(1):728-742.

12.Muscle regeneration controlled by a designated DNA dioxygenase. Hongye Wang, Yile Huang, Ming Yu, Yang Yu, Sheng Li, Huating Wang, Hao Sun, Bing Li, and Guo-Liang Xu, and Ping Hu*. Cell Death and Disease, May 25;12(6):535, 2021.

13.Effect of transcriptional regulatory factor FoxO3a on central nervous system oxygen toxicity. Yanan Zhang, Benming You, Yuliang Chen, Chengwei Xie, Guoyang Huang, Runping Li*, Ping Hu*. Frontiers in Physiology, section Environmental, Aviation and Space Physiology. Dec 18;11:596326, 2020.

14.Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration. Shen'ao Zhou, Wei Zhang, Caixia Wei, Sheng Li, Yu Yang, Jie Qin, Dan Liu, Hongye Wang, Wenjun Yang, Gaihong Cai, She Chen, Yingzhe Ding, Huating Wang, Xiexiang Shao, Jianhua Wang, Ping Hu*, and Liming Sun*. Cell Research, 2020 Dec;30(12):1063-1077. (Featured Cover story)

15.The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Lantian Wang*, Jing Fan*, Lili Han*, Haonan Qi, Yimin Wang, Hongye Wang, Suli Chen, Lei Du, Sheng Li, Gaoxiang Ge, Weijun Pan, and Ping Hu*, and Hong Cheng*. Cell Death and Disease, 2020 May 11;11(5):357.

16.Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1. Qi Yin, Hongye Wang, Na Li, Yifu Ding, Zhenfei Xie, Lifang Jin, Yan Li, Qiong Wang, Xinyi Liu, Liuqing Xu, Yanbo Cheng, Kai Wang,1 Cuiqing Zhong, Qian Yu, Wei Tang, Wanjin Chen, Wenjun Yang, Fan Zhang, Chen Ding, Lan Bao, Bin Zhou, Ping Hu,* and Jinsong Li*. Cell Research, 2020 Feb;30(2):133-145. (Featured Cover story)

17.Dual function of VGLL4 in muscle regeneration. Xue Feng, Zuoyun Wang, Fei Wang, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu*, Lei Zhang*. EMBO J, 2019, 38 (17): e101051.

18.Dkk3 dependent transcriptional regulation controls ageing induced skeletal muscle atrophy. Jie Yin, Lele Yang, Yangli Xie, Yan Liu, Sheng Li, Wenjun Yang, Bo Xu, Hongbin Ji, Kun Wang, Gang Li, Lin Chen & Ping Hu*. Nature Communications. May. 1, 9(1):1752. 2018.

19.Hierarchical signaling transduction of the immune and muscle cell crosstalk in muscle regeneration. Wenjun Yang and Ping Hu*. Cell Immunol. 2018 April, 326: 2-7. IF:2.995

20.MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Xianlu L. Peng, Karl K. So, Liangqiang He, Yu Zhao, Jiajian Zhou, Yuying Li, Mingze Yao, Bo Xu, Suyang Zhang，Hongjie Yao, Ping Hu, Hao Sun, and Huating Wang. Nucleic Acids Res. 2017,45:8785-8805.

21.In vitro Differentiation of ESCs/iPSCs to Myogenic Lineage: Moving towards Cell Therapy. Julieta Gasparri and Ping Hu*. Cellular and Molecular Medicine 2015,1(1):9-12. (IF: 5.164)

22.A muscle secretive protein Msp marks ageing related muscular dystrophy. Jie Yin, Yan Liu, Wenjun Yang, and Ping Hu*. Jouranl of Cachexia Sarcopenia and Muscle. 2015, 6: 409-413. (IF: 7.883)

23.Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion. Xin Fu, Jun Xiao, Yuning Wei, Sheng Li, Yan Liu, Kun Sun, Hao Sun, Huating Wang, Zongkang Max Zhang, Baoting Zhang, Chun Sheng, Hongyan Wang*, and Ping Hu*. Cell Research. 2015. Jun;25(6):655-73. cover story with preview）

24.Genome-wide roles of Foxa2 in directing liver specification. Chenhuan Xu, Xiaowen Lv, Zhang Chen, Zhiying He, Guangpeng Li, Yue Ma, Lijian Hui, Bin Xie, Yuan Gao, Xiaoyan Ding, Yiping Hu, Ping Hu *, Jing-Dong J. Han*, and Xin Wang. J Mol Cell Biol，2012, 4(6), 420-422. (IF: 6.459)

25.Co-dependent Activators Direct Myoblast Specific MyoD Transcription.  Ping Hu, Kenneth G. Geles, Ji-Hye Paik, Ronald A. DePinho, and Robert Tjian. Developmental Cell, 2008, Oct; 15(4): 534-546.

26.MyoD targets TAF3/TRF3 to activate myogenin transcription.  Maria DE. Deato, Michael T. Marr, Theo Sottero, Carla Inouye, Ping Hu, and Robert Tjian.  Molecular Cell, 2008, October 10; 32(1):96-105.

27.CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression. Ping Hu, Kalpana Samudre, Si Wu, Yuling Sun, and Nouria Hernandez. Mol Cell. 2004 Oct 8;16(1):81-92.

28.A Minimal RNA Polymerase III Transcription System from Human Cells Reveals Positive and Negative Regulatory Roles for CK2. Ping Hu, Si Wu, and Nouria Hernandez. Mol. Cell, 2003 Sep;12(3):699-709.

【所获荣誉和奖励】