【个人简介】

吴宏楷，理学博士，副研究员，博士生导师。2012年起在广州医科大学附属第一医院/广州呼吸健康研究院工作。

【研究方向】

适应性免疫受体组库与疾病免疫机制研究；生物信息学

【科研项目】

1. 广东省学基金面上项目, 4型腺病毒HVR7抗原表位的改变对其抗体谱系及免疫应答差异机制研究，2018-05-01至2021-04-30，10万，已结题，主持。

2. 广州医科大学科研强基项目，腺病毒六邻体中和表位替换对抗体免疫应答的影响及其差异规律研究，2023-01-01至2024-12-31，15万，执行期满，主持。

【代表性论文及著作】

1. Gong Z, Zhang W, Du B, Wu H, Li S. The case for caution in the application of whole-exome sequencing data for immune repertoire analysis. Briefings in bioinformatics 2026, 27(4): bbag419.

2. Huang J, Lin Z, Lin J, Xie S, Xia S, Chen G, Zheng Z, Xu Z, Liu F, Wu H, Li S. Causal role of lipid metabolism in pulmonary alveolar proteinosis: an observational and mendelian randomisation study. Thorax 2024, 79(2): 135-143.

3. Li X, Zheng A, Liu J, Shi M, Liao B, Xie S, Yan R, Gan Y, Zuo X, Gong M, Wu H, Wang Z. Assessing the chronic hepatitis B adaptive immune response by profiling specific T-cell receptor repertoire. Antiviral research 2023, 214: 105608.

4. Xie S, Yan R, Zheng A, Shi M, Tang L, Li X, Liu J, Gan Y, Wang Y, Jiang D, Liu L, Wu H, Wang Z. T cell receptor and B cell receptor exhibit unique signatures in tumor and adjacent non-tumor tissues of hepatocellular carcinoma. Frontiers in immunology 2023, 14: 1161417.

5. Wu H, Zhou Z, Xie S, Yan R, Gong M, Tian X, Wang Z. Similarity measurements of B cell receptor repertoire in baseline mice showed spectrum convergence of IgM. BMC immunology 2022, 23(1): 11.

6. Wu H, Liao B, Li X, Liu H, Gong M, Shi H, Xie S, Guo F, Chen K, Yan R, Zhao H, Li L, Zheng A, Liu Y, Wang Z. Increased hepatitis B virus quasispecies diversity is correlated with liver fibrosis progression. Infection, genetics and evolution 2021, 93: 104938.

7. Lian Y, Xu Y, Gu Y, Bi Y, Liao C, Zhao M, Liao X, Wang Z, Wu H, Huang Y. Distinct T-cell receptor profiles associated with hepatitis B e antigen seroconversion during entecavir treatment. Liver international 2020, 40(11): 2672-2684.

8. Li A, Li A, Deng Z, Guo J, Wu H. Cross-Species Annotation of Expressed Genes and Detection of Different Functional Gene Modules Between 10 Cold- and 10 Hot-Propertied Chinese Herbal Medicines. Frontiers in genetics 2020, 11: 532.

9. Wu H, Chen J, Yang L, Li A, Su D, Lin Y, Chen D. Emergence and genomic analysis of MDR Laribacter hongkongensis strain HLGZ1 from Guangzhou, China. The Journal of antimicrobial chemotherapy 2018, 73(3): 643-647.

10. Chen Y, Xu Y, Zhao M, Liu Y, Gong M, Xie C, Wu H, Wang Z. High-throughput T cell receptor sequencing reveals distinct repertoires between tumor and adjacent non-tumor tissues in HBV-associated HCC. Oncoimmunology 2016, 5(10): e1219010.