吴宏楷，男，本科毕业于中山大学（生物科学和计算机软件双专业），2010年获中山大学理学博士学位。现工作于广州医科大学附属第一医院/广州呼吸健康研究院，呼吸疾病国家重点实验室。副研究员，广州医科大学博士生导师，专业方向为生物信息学。
近年来主要研究T细胞和B细胞受体序列多样性特征，及其与病毒感染和肿瘤免疫的关系；利用比较基因组学的方法研究细菌和病毒的重组和演化，及其与病原体特性和疾病进展的关系。已发表SCI论文34篇，其中第一作者论文6篇，通讯作者论文10篇。
代表性论文：
Xueying, Li; Anqi, Zheng; Jiabang, Liu; Mengfen, Shi; Baolin, Liao; Shi, Xie; Rong, Yan; Yifan, Gan; Xuan, Zuo; Mingxing, Gong; Hongkai, Wu; Zhanhui, Wang ; Assessing the chronic hepatitis B adaptive immune response by profiling specific T-cell receptor repertoire, Antiviral research, 2023, 214
Shi, Xie; Rong, Yan; Anqi, Zheng; Mengfen, Shi; Longqing, Tang; Xueying, Li; Jiabang, Liu; Yifan, Gan; Yu, Wang; Deke, Jiang; Li, Liu; Hongkai, Wu; Zhanhui, Wang ; T cell receptor and B cell receptor exhibit unique signatures in tumor and adjacent non-tumor tissues of hepatocellular carcinoma, Frontiers in Immunology, 2023, 14
Hongkai Wu; Zhichao Zhou; Shi Xie; Rong Yan; Mingxing Gong; Xingui Tian; Zhanhui Wang; Similarity measurements of B cell receptor repertoire in baseline mice showed spectrum conv ergence of IgM, BMC Immunology, 2022, 23: 11
Hongkai Wu; Baolin Liao; Xueying Li; Huiyuan Liu; Mingxing Gong; Haiyan Shi; Shi Xie; Fengxia Guo; Keng Chen; Rong Yan; Han Zhao; Liya Li; Anqi Zheng; Yu Liu; Zhanhui Wang; Increased hepatitis B virus quasispecies diversity is correlated with liver fibrosis progression, Infection, Genetics and Evolution, 2021, 93: 104938
Mingxing, Gong; Xueying, Li; Anqi, Zheng; Hongxu, Xu; Shi, Xie; Rong, Yan; Hongkai, Wu; Zhanhui, Wang; Age-related changes in the TRB and IGH repertoires in healthy adult males and females, Immunology Letters, 2021, 240: 71-76
Miaoxian Zhao; Xueying Li; Shi Xie; Mingxing Gong; Rong Yan; Anqi Zheng; Ying Xu; Hongkai Wu; Zhanhui, Wang; The dynamics and association of B and T cell receptor repertoires up on antibody response to hepatitis B vaccination in healthy adults, Human Vaccines & Immunotherapeutics, 2021, 17(9): 3203-3213
Arong Li; Aqian Li; Zhijun Deng; Jiewen, Guo; Hongkai Wu; Cross-Species Annotation of Expressed Genes and Detection of Different Functional Gene Modules Between 10 Cold- and 10 Hot-Propertied Chinese Herbal Medicines, Frontiers in Genetics, 2020, 11: 0-532
Yifan Lian; Ying Xu; Yurong Gu; Yanhua Bi; Chunhong Liao; Miaoxian Zhao; Xialin Liao; Zhanhu, Wang; Hongkai Wu; Yuehua Huang; Distinct T-cell receptor profiles associated with hepatitis B e antigen seroconversion during entecavir treatment, Liver International, 2020, 40(11): 2672-2684
Wenkuan Liu; Duo Xu; Yun Xu; Shuyan Qiu; Li Zhang; Hongkai Wu; Rong Zhou; Protein profile of well-differentiated versus un-differentiated human bronchial/tracheal epithelial cells, Heliyon, 2020, 6(6): 0-e04243
Xingui Tian; Hongkai Wu; Rong Zhou; Molecular evolution of human adenovirus type 16 through multiple recombination events, Virus genes, 2019, 55(6):769-778
Hongkai Wu; Jianhuan Chen; Ling Yang; Arong Li; Danhong Su; Yongping Lin; Dingqiang Chen; Emergence and genomic analysis of multi-drug resistant Laribacter hongkongensis strain HLGZ1 from Guangzhou, China, Journal of Antimicrobial Chemotherapy, 2018, 73(3):643-647
Ying Xu; Yu Liu; Miaoxian Zhao; Yunqing Chen; Cantao Xie; Mingxing Gong; Haohui Deng; Xueying Li; Jian Sun; Jinlin Hou; Hongkai Wu; Zhanhui Wang; Dynamic Perturbations of CD4 and CD8 T Cell Receptor Repertoires in Chronic Hepatitis B Patients upon Oral Antiviral Therapy, Frontiers in immunology, 2017, 8:1142
Yunqing Chen; Ying Xu; Miaoxian Zhao; Yu Liu; Mingxing Gong; Cantao Xie; Hongkai Wu; Zhanhui Wang; High-throughput T cell receptor sequencing reveals distinct repertoires between tumor and adjacent non-tumor tissues in HBV-associated HCC, Oncoimmunology 2016, 5(10):e1219010
