周艳双，博士，副教授，南山学者后备人才

教育经历

2012.09 - 2019.12中国科学院广州生物医药与健康研究院，博士

2008.09 - 2012.06湖南师范大学，生命科学学院，学士

工作经历

2021.01 –至今 广州医科大学，副教授

2020.02 – 2020.09生物岛实验室，助理研究员

研究方向：线粒体功能及细胞命运

1.线粒体自噬及相关mtDNA突变引起的线粒体疾病的研究

2.相分离介导的线粒体转录及代谢调控

代表性研究论文

1.Y. Zhou#, Q. Long#, H. Wu, W. Li, J. Qi, Y. Wu, G. Xiang, H. Tang, L. Yang, K. Chen, L. Li, F. Bao, H. Li, Y. Wang. M. Li and X. Liu*. Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy. 2020. 16(3): 562-574. (封面文章)

2. Q. Long#,Y. Zhou#, H. Wu#, S. Du, M. Hu, J. Qi, W. Li, J. Guo, Y. Wu, L. Yang, G. Xiang, L. Wang, S. Ye, J. Wen, H. Mao, J. Wang, H. Zhao, W. Chan, J. Liu, Y. Chen, P. Li and X. Liu*. Phase separation drives the self-assembly of mitochondrial nucleoids for transcription modulation. Nature Structural & Molecular Biology. 2021. 28(11):900-908.

3.Y. Zhou#, Q. Long#, X. Liu *. A new sight: topology-dependent mitophagy. Cell Biology and Toxicology. 2020. 36, 199-204.

4.W.Li #, Q.Long #, Hao Wu #,Y. Zhou, L. Duan, H. Yuan, Y. Ding, Y. Huang, Y. Wu, J. Huang, D. Liu, B. Chen, J. Zhang, J. Qi, S. Du, L. Li, Y. Liu, Z. Ruan, Z. Liu, Z. Liu, Y. Zhao, J. Lu, J. Wang, W. Chan, X. Liu*. Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nature Communications. 2022. 13(1):7414.

5. F. Bao, L. Zhou, R. Zhou, Q. Huang, J. Chen, S. Zeng, Y. Wu, L. Yang, S. Qian, M. Wang, X. He, S. Liang, J. Qi, G. Xiang, Q. Long, J. Guo, Z. Ying,Y. Zhou, Q. Zhao, J. Zhang, D. Zhang, W. Sun, M. Gao, H. Wu, Y. Zhao, J. Nie, M. Li, Q. Chen, J. Chen, X. Zhang, G. Pan, H. Zhang, M. Li, M. Tian, X. Liu*. Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances. 2022. 8(15):eabk2376.

6. L. Li#, K. Chen#, T. Wang#, Y. Wu#, G. Xing, M. Chen, Z. Hao, C. Zhang, J. Zhang, B. Ma, Z. Liu, H. Yuan, Z. Liu, Q. Long,Y. Zhou, J. Qi, D. Zhao, M. Gao, D. Pei, J. Nie, D. Ye, G. Pan, and X. Liu*. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism. 2020. 2(9): p. 882-892.

7. K. Chen, Q. Long, G. Xing, T. Wang, Y. Wu, L. Li, J. Qi,Y. Zhou, B. Ma, H. R. Scholer, J. Nie, D. Pei and X. Liu*. Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. The EMBO Journal. 2020 39(1):e99165.

8. Z. Ying# , G. Xiang, L# . Zheng, H. Tang, L. Duan, X. Lin, Q. Zhao, K. Chen, Y. Wu, G. Xing, Y. Lv, L. Li, L. Yang, F. Bao, Q. Long,Y. Zhou, X. He, Y. Wang, M. Gao, D. Pei, W.Y. Chan, and X. Liu*. Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming. Cell Metabolism. 2018. 28(6): p. 935-945 e5.

9. G. Xiang, L. Yang# , Q. Long# , K. Chen, H. Tang, Y. Wu, Z. Liu,Y. Zhou, J. Qi, L. Zheng, W. Liu, Z. Ying, W. Fan, H. Shi, H. Li, X. Lin, M. Gao, J. Liu, F. Bao, L. Li, L. Duan, M. Li and X. Liu*. BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy. 2017: p. 1-13.

10. K. Chen# , Q. Long# , T. Wang, D. Zhao,Y. Zhou, J. Qi, Y. Wu, S. Li, C. Chen, X. Zeng, J. Yang, Z. Zhou, W. Qin, X. Liu, Y. Li, Y. Li, X. Huang, D. Qin, J. Chen, G. Pan, H. R. Scholer, G. Xu, X. Liu* and D. Pei*. Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Reports. 2016. 17(11): p. 1641-1656.

11. Q. Long# , D. Zhao# , W. Fan, L. Yang,Y. Zhou, J. Qi, X. Wang* and X. Liu*. Modeling of Mitochondrial Donut Formation. Biophysical Journal. 2015. 109(5): p. 892-9.

获得奖励

2021年，广东省科学技术奖自然科学一等奖（2020年）

2021年，第一届全国博士后创新创业大赛优胜奖

邮箱：zhouyanshuang@gzhmu.edu.cn