【个人简介】

张文亮，2020年6月获中山大学遗传学博士学位，随后入职香港大学深圳医院和中国科学院深圳先进技术研究院，从事博士后研究工作。2022年9月以“南山学者”高层次人才引进广州医科大学生命科学学院，被聘任为教授、博士后合作导师和研究生导师。

带领团队围绕非经典开放阅读框编码潜能及致癌机制、组织空间分子生态智能解析与重构，以及多组学资源与计算工具开展研究。以通讯作者或第一作者在 Journal of Experimental & Clinical Cancer Research（2025a, 2025b）、Nucleic Acids Research（2022a，2022b）、Genomics, Proteomics & Bioinformaitcs（2026, 2020）、Knowledge-Based Systems（2025）、Bioinformatics (2024)、Briefings in Bioinformatics（2019）等国际知名期刊发表论文近20篇，累积影响因子 140+ ，已被授权/受理第一发明人国家发明专利5项，相关成果多次受邀在中国人工智能学会生物信息学与人工生命专委会委员学术年会和广东省生物信息学会年会等国内外学术大会做报告，产生了较广泛的国际影响。

目前兼任广东省生物信息学会理事会副秘书长、理事，中国人工智能学会生物信学与人工生命专委会委员，广东省生物化学与分子生物学学会青年委员，广东高校科技成果转化中心专家库专家等，以及iMeta、GigaScience、Precision Clinical Medicine、Interdisciplinary Sciences: Computational Life Sciences等国际知名SCI期刊青年编，受邀担任Signal Transduction and Targeted Therapy、Molecular Cancer、Clinical and Molecular Hepatology、Journal of Experimental & Clinical Cancer Research、Molecular Biomedicine等40余本国际知名SCI期刊审稿人。

此外，在人才培养方面也取得了较为突出的成效。独立指导博士后获国家自然科学基金青年人才类项目资助3人次、国家博士后资助计划C类资助1人次，多名博士后出站后进入国内知名高校和科研院所工作，并担任副研究员等职务。指导本科生获“挑战杯”省级银奖1项、省级大学生创新创业项目1项、全国生命科学竞赛三等奖1项，以及校级大学生创新创业项目多项。

本课题组常年招收生物医学和生物信息学等研究方向的博士后, 研究生和科研助理职位，欢迎有挑战精神的科研人员通过邮箱投简历，应聘加盟我们团队。课题组网址：http://www.biomedical-web.com/omicslab/Home.html。

【研究方向】

肿瘤生物学；生物信息学；医疗人工智能建模；多组学挖掘

【科研项目】

1. 广州医科大学高水平大学建设南山学者骨干人才启动经费，在研，2022.09至2027.09，200万，在研，主持。

2. 国家自然科学基金青年项目，2022.1至2024.12，30万，已结题，主持；

3. 广东省基础与应用基础基金青年项目，2020.10至2023.9，10万，已结题，主持；

4. 中国博士后科学基金，2021.6-2022.5，8万，已结题，主持；

【代表性论文及著作】

* 通讯作者；# 共同第一作者

1. Cheng Wu#, Ke Si#, Shuai Mao#, Zehang Jiang#, Douyue Li1, Haipeng Zhu, Ningning Sun, Weiling Liang, Wenliang Zhang*. Single-cell and spatial multi-omics reveal inter-focal heterogeneity yet convergent immunosuppressive programs in multifocal hepatocellular carcinoma. 2026, bioRxiv, doi: https://doi.org/10.64898/2026.04.21.719788 (Under review at Clinical and Molecular Hepatology (IF 21.7), 唯一通讯)

2. Lihong Huang #*, Minglei Yang#, Douyue Li, Guozhong Jiang*, and Wenliang Zhang*. A High-Resolution RNA Editome Landscape Reveals an ADAR1-CDK13 Editing Feedback Loop Driving cGAS-STING Activation in Early Esophageal Squamous Cell Carcinoma. 2026, bioRxiv, doi: https://doi.org/10.64898/2026.01.29.701210 (Revised manuscript for Genes & Diseases (IF 14.6), 最后通讯)

3. Zehang Jiang#, Zhuochao Min #, Zhanying Wu #, Yubin Chen , Zhiyong Wu , Huashu Wen , Cheng Wu , Jia Guo , Ke Si , Douyue Li , Guoying Wang , Shuai Mao , Weizhong Li*, Binghui Zeng*, Wenliang Zhang*. A Spatially Resolved Atlas of Alternative Polyadenylation Across 18 Human Tissues and 76 Disease States. Genomics, Proteomics & Bioinformatics, 2026; qzag042. (IF 7.2, 最后通讯作者, Online published)

4. Haipeng Zhu#, Douyue Li#, Zehang Jiang, Minglei Yang*, Guoying Wang*，Wenliang Zhang*. AWTI-Net Enables Accurate and Interpretable Functional Assessment of Disease-Associated LncRNA Mutations. Interdisciplinary Sciences: Computational Life Sciences , 2026. (IF 5.2, 最后通讯作者, Online published)

5. Ke Si#, Lantian Zhang#, Zehang Jiang, Zhiyong Wu, Zhanying Wu, Yubin Chen, Weifei Liang, Xiaoren Zhang*, and Wenliang Zhang*. A Novel lncRNA-Mediated Signaling Axis Governs Cancer Stemness and Splicing Reprogramming in Hepatocellular Carcinoma with Therapeutic Potential. J Exp Clin Cancer Res. 2025;44(1):287. (IF 14.3, 最后通讯)

6. Lei Zhao#, Ke Si#, Shenjian Luo#, Lantian Zhang, Shuai Mao, Wenliang Zhang*. Non-canonical activation of MAPK signaling by the lncRNA ASH1L-AS1-encoded microprotein APPLE through inhibition of PP1/PP2A-mediated ERK1/2 dephosphorylation in hepatocellular carcinoma. J Exp Clin Cancer Res. 2025;44(1):200. (IF 14.3，唯一通讯)

7. Wenliang Zhang#*, Yan Zhang#, Zhuochao Min#, Guodong Liang, Jing Mo, Zhen Ju, Binghui Zeng, Wen Guan, Yan Zhang, Jianliang Chen, Qianshen Zhang, Hanguang Li, Chunxia Zeng,Yanjie Wei*, and Godfrey Chi-Fung Chan*.  COVID19db: a comprehensive database platform to discover potential drugs and targets of COVID-19 at whole transcriptomic scale, Nucleic Acids Research, 2022, 50(D1), D747-D757 (IF 19.16，第一和共同通讯)

8. Wenliang Zhang#*, Yang Liu#, Zhuochao Min#, Jing Mo, Zhen Ju, Wen Guan, Binghui Zeng, Yang Liu, Jianliang Chen, Qianshen Zhang, Hanguang Li, Chunxia Zeng, Yanjie Wei*, and Godfrey Chi-Fung Chan*. circMine: a comprehensive database to integrate, analyze and visualize human disease related circRNA transcriptome, Nucleic Acids Research, 2022, 50(D1),D83-D92 (IF 19.16，第一和共同通讯)

9. Haipeng Zhu#, Guoying Wang#, Zhihong Liao, Wenliang Zhang*. AITL-Net: An adaptive interpretable transfer learning network with robust generalization for liver cancer recognition. Knowledge-Based Systems, 2025; 318: 113473 (IF 8.1，唯一通讯)

10. Douyue Li#, Zhuochao Min#, Jia Guo#, Yubin Chen, Wenliang Zhang*. ExpOmics: a comprehensive web platform empowering biologists with robust multi-omics data analysis capabilities, Bioinformatics, 2024;40(8):btae507. (IF 5.4，唯一通讯)

11. Yang Liu#, Zhuochao Min#, Jing Mo #, Zhen Ju, Jianliang Chen, Lantian Zhang, Weiling Liang, Hanguang Li, Godfrey Chi-Fung Chan*, Yanjie Wei*, and Wenliang Zhang*. ExomiRHub: a comprehensive database platform to integrate and analyze human extracellular miRNA transcriptome for discovering non-invasive biomarkers, Computational and Structural Biotechnology Journal, 2024;23:3104-3116.(IF 4.5，最后通讯)

12. Likang Zhang#, Jiahui Sun#, Sheng Liu, Wenliang Zhang*, and Jianlong Zou*. 3D culture of the spinal cord with roots as an ex vivo model for comparative studies of motor and sensory nerve regeneration, Experimental Neurology, 2023;362:114322. (IF 5.6，共同通讯)

13. Wenliang Zhang, Haiyue Zhang, Huan Yang, Miaoxin Li, Zhi Xie and Weizhong Li*. Computational resources associating diseases with genotypes, phenotypes and exposures, Briefings in Bioinformatics, 2019, 20(6),2098-2115  (IF 9.1，第一作者)

14. Wenliang Zhang#*, Binghui Zeng#, Huancai Lin,Wen Guan,Jing Mo,Yanjie Wei,Qianshen Zhang,Dongsheng Yu*, Weizhong Li*&Godfrey Chi-FungChan*. CanImmunother:a manually curated database for identification of cancer immunotherapies associating with biomarkers,targets, and clinical effects, OncoImmunology, 2021, 10(1),1944553  (IF 8.1，第一和共同通讯)

15. Wenliang Zhang#, Binghui Zeng#, Minglei Yang, Huan Yang, Jianbo Wang, Yongjie Deng, Guocai Yao, Song Wu, Haiyue Zhang and Weizhong Li *. ncRNAVar: a manually curated database for identification and validation of noncoding RNA variants associated with human diseases, Journal of Molecular Biology, 2021, 433(11):166727.  (IF 6.2，第一作者)

16. Guocai Yao#, Wenliang Zhang#, Minglei Yang, Huan Yang, Jianbo Wang, Haiyue Zhang, Lai Wei, Zhi Xie and Weizhong Li*. MicroPhenoDB associates etagenomic data with pathogenic microbes, microbial core genes and human disease phenotypes, Genomics, Proteomics & Bioinformatics,2020, 18(6),760-772 (IF 7.6，共同第一作者)

17. Wenliang Zhang, Guocai Yao, Jianbo Wang, Minglei Yang, Jing Wang, Haiyue Zhang, Weizhong Li*. ncRPheno: a comprehensive database platform for identification and validation of disease related noncoding RNAs, RNA Biology, 2020, 17:7, 943-955  (IF 5.35，第一作者)

18. Wenliang Zhang#, Shaoyang Zhang#, Wen Guan#, Zhicong Huang, Jianqiu Kong, Chunlong Huang, Shulan Yang*, Haihe Wang*. Poly C binding protein 1 regulates p62/SQSTM1 mRNA stability and autophagic degradation to repress tumor progression, Frontiers in Genetics, 2020, 14;11:930.（第一作者，IF=4.8)

19. Wenliang Zhang#, Shi Hongshun#, Zhang Mingming, Liu Bin, Mao Shuai, Li Li, Tong Fang, Liu Guoliang, Yang Shulan, and Wang Haihe*.Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation, International Journal of Biochemistry and Cell Biology, 2016，73:127-136.（第一作者，IF=5.6)

20. Wenliang Zhang, Mingming Zhang, Bin Liu, Hongshun Shi, Haihe Wang*. Optimal timing of autophagy occurrence induced by earle's balanced salts solution in DLD-1, HCT-116, A2780, CHO, Hep G2 and SMMC7721 cancer cell lines. 中山大学学报 (自然科学版), 2016, 55(4).（第一作者(英文文章)）

【所获荣誉和奖励】

1. 2025年，Precision Clinical Medicine 期刊2025年度优秀审稿人；

2. 2021年，第十届全国生物信息与系统生物学学术大会优秀墙报一等奖；