王一倩，女，博士，副教授，硕士研究生导师。2019年博士毕业于美国内布拉斯加大学医学中心（弗雷德和帕梅拉·巴菲特癌症研究中心）。同年8月进入广州医科大学生科院工作。主要从事血液病包括急性白血病等的发展和耐药机制研究。主持国家自然科学基金1项、市厅级课题2项。近五年以第一作者/通讯作者在Cancer Gene Therapy、Leukemia Research、Frontiers in Immunology、Annals of Medicine、Scientific Reports等杂志发表SCI论文10篇。担任Aging、Orphanet Journal of Rare Diseases等杂志审稿人。
联系邮箱：yiqian.wang@gzhmu.edu.cn
研究方向：白血病的发病机制与新型治疗靶点的发现
主持科研项目
1. 国家自然科学基金青年项目，CBFB-MYH11融合基因上调IL1RL1介导inv(16)急性髓系白血病化疗耐药的机制研究，30万。
2. 广州市科学技术局基础研究计划项目，探究白血病细胞中IL-33激活p38 MAPK通路对抑制细胞凋亡的作用机制，5万。
3. 广东省教育厅青年创新人才类项目，IL1RL1/IL-33信号通路在急性髓系白血病发展中的机制研究，2.5万。
代表性论文（*通讯）
1. Wang Y, Hou H, Liang Z, Chen X, Lian X, Yang J, Zhu Z, Luo H, Su H, Gong Q. P38 MAPK/AKT signalling is involved in IL-33-mediated anti-apoptosis in childhood acute lymphoblastic leukaemia blast cells. Ann Med. 2021 Dec;53(1):1461-1469.
2. Wang Y, Luo H, Wei M, Becker M, Hyde RK, Gong Q. IL-33/IL1RL1 axis regulates cell survival through the p38 MAPK pathway in acute myeloid leukemia. Leuk Res. 2020 Sep;96:106409.
3. Wang Y, Su H, Yan M, Zhang L, Tang J, Li Q, Gu X, Gong Q. Interleukin-33 Promotes Cell Survival via p38 MAPK-Mediated Interleukin-6 Gene Expression and Release in Pediatric AML. Front Immunol. 2020 Nov 26;11:595053.
4. Wang Y, Xie Y, Williams J, Hang Y, Richter L, Becker M, Amador C, Oupický D, Hyde RK. Use of polymeric CXCR4 inhibitors as siRNA delivery vehicles for the treatment of acute myeloid leukemia. Cancer Gene Ther. 2020 Feb;27(1-2):45-55.
5. Wang Y, Richter L, Becker M, Amador C, Hyde RK. IL1RL1 is dynamically expressed on Cbfb-MYH11+ leukemia stem cells and promotes cell survival. Sci Rep. 2019 Feb 11;9(1):1729.
6. Zhang L, Bao LJ, Hong ZD, Yan MX, Zhang ZH, Li YM, Ye Q, Wang YQ*. Dysregulated Serum Cytokine Production in Pediatric Patients with β-Thalassemia Major. Hemoglobin. 2022 Jul;46(4):191-196.
7. Wu Y, Chen X, Jiao S, Wang Y*. Upregulated pigment epithelium-derived factor (PEDF) promotes trophoblast apoptosis and inhibits invasion in preeclampsia. Reprod Biol. 2021 Dec;21(4):100576.
8. Yan M, Wu Y, Xia J, Zhang X, Wang Y*. Cytologic diagnosis of metastatic embryonal rhabdomyosarcoma in cerebrospinal fluid: A case report. Diagn Cytopathol. 2021 Aug;49(8):E320-E324.
9. Zhang L, Liu L, Luo H, Xu W, Chen H, Yan M, Wang Y*. Combination therapy for pediatric patients with Kasabach-Merritt phenomenon: A single-center retrospective study. Medicine (Baltimore). 2022 Aug 26;101(34):e30296.
