粟海波，生物化学与分子生物学博士，副教授，硕士研究生导师。主要聚焦于研究训练免疫代谢和表观遗传调控机制及其在自身炎症性疾病发生中的作用，致力于研发训练免疫关联疫苗和探究其在诸如肿瘤等疾病中免疫治疗潜能。

联系邮箱：suhaibo899@163.com

研究方向：训练免疫中代谢和表观遗传重编程调控机制

主要科研项目：

1.国家自然科学基金面上项目；YAP-FOXK1在BCG诱导的训练免疫中调控甲羟戊酸代谢和H3K4me3重编程的机制研究；2023.01-2026.01，主持。

2.国家自然科学基金青年科学基金项目；结核分枝杆菌潜伏抗原Rv2029c介导保护性免疫应答的分子机制；2017.01-2019.12，主持。

3.广东省教育厅重点项目：天然免疫记忆形成起始免疫代谢和表观遗传重编程的机制；2023.01-2025.01，主持。

4.广州市科学技术局基础与应用基础研究重点项目：结核分枝杆菌PPE27蛋白通过TLR2_NLRP3信号通路调控DCs活化和Th17免疫反应机制研究；2022.04-2024.03，主持。

代表性论文：

[1]. Su HB, Huang JX, Weng SF, Zhang BY, Zhang TR, Xu Y. Glutahtione synthesis primes monocytes metabolic and epigenetic pathway for β-glucan-trained immunity.Redox Biology. 2021 Dec 7;48:102206.

[2]. Su HB, Liang ZP, Weng SF, Sun C, Huang JX, Zhang TR, Wang XL, Wu SS, Zhang Z, Zhang Y, Gong Q, Xu Y. miR-9-5p regulates immunometabolic and epigenetic pathways in β-glucan-trained immunity via IDH3α.JCI Insight. 2021 May 10;6(9):e144260.

[3]. Su HB, Peng BZ, Zhang Z, Liu ZJ, Zhang Z.The Mycobacterium tuberculosis glycoprotein Rv1016c protein inhibits dendritic cell maturation, and impairs Th1 /Th17 responses during mycobacteria infection.Mol Immunol. 2019 May;109:58-70.

[4]. Su HB, Zhang Z, Liu ZJ, Peng BZ, Kong C, Wang HH, Zhang Z, Xu Y.Mycobacterium tuberculosis PPE60 antigen drives Th1/Th17 responses via Toll-like receptor 2-dependent maturation of dendritic cells.Journal of Biological Chemistry. 2018 Jun 29;293(26):10287-10302.

[5]. Su HB, Zhu SL, Zhu L, Kong C, Huang Q, Zhang Z, Wang HH, Xu Y. Mycobacterium tuberculosis Latent Antigen Rv2029c from the Multistage DNA Vaccine A39 Drives TH1 Responses via TLR-mediated Macrophage Activation.Front Microbiol. 2017 Nov 17;8:2266.

[6]. Su HB, Zhu SL, Zhu L, Huang W, Wang H, Zhang Z, Xu Y. Recombinant Lipoprotein Rv1016c derived from Mycobacterium tuberculosis is a TLR-2 ligand that induces macrophages apoptosis and inhibits MHC II antigen processing.Frontiers in Cellular and Infection Microbiology. 2016 Nov 18;6:147.