刘恒，教授、博士生导师，获得2022年国家自然科学基金海外高层次青年人才项目资助，广州医科大学“南山学者”岗位第三层次人才。本科、博士毕业于中国科学技术大学，2015年起在美国匹兹堡大学医学院从事G蛋白偶联受体(G protein-coupled receptors, GPCRs）的结构药理学研究。2022年12月加入广州医科大学-广州生物院联合生科院，研究方向为GPCRs等重要药物靶点的结构药理学研究及创新药物（纳米抗体和小分子化合物）研发。前期工作发表在Nature、Nature Structural & Molecular Biology、PNAS、Nature Communications等期刊。

邮箱：hengliu@gzhmu.edu.cn

主要代表成果：

1. Liu, H., H.R. Kim, R.N.V.K. Deepak, L. Wang, K.Y. Chung, H. Fan, Z. Wei, C. Zhang, Orthosteric and allosteric action of the C5a receptor antagonists. Nat. Struct. Mol. Biol. (2018).

2. Qi, X. *, Liu, H.*, Thompson, B., McDonald, J., Zhang, C., & Li, X. Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi. Nature. (2019). (*Equal contribution)

3.Liu,H., Dapeng Sun, Alexander Myasnikov, Marjorie Damian, Jean-Louis Baneres, Ji Sun, Cheng Zhang. Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren. Nat Commun. (2021).

4.Liu,H.*, R.N.V.K. Deepak*, Anna Shiriaeva*, Cornelius Gati, Alexander Batyuk, Hao Hu, Uwe Weierstall, Wei Liu, Lei Wang, Vadim Cherezov, Hao Fan, Cheng Zhang, Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2. PNAS. (2021). (*Equal contribution)

5. Zhuang, Y*., Liu, H.*, Edward Zhou, X., Verma, R., de Waal, P., Jang, W., Xu, T., Wang, L., Meng, X., Zhao, G., Kang, Y., Melcher, K., Fan, H., Lambert, N., Xu, H. E., Zhang, C. Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling. Nat Commun. (2020). (*Equal contribution)

6. A. Dumitru*, KRNV Deepak*, Liu, H.*, M. Koehler, C. Zhang, H. Fan, D. Alsteens. Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism. Communications Biology. (2020). (*Equal contribution)