陈捷凯，男，博士，研究员。

个人履历：

2002-2006 中山大学 生物科学 学士；

2006-2011 中国科学院广州生物医药与健康研究院 生化与分子生物学 博士；

2011-2013 中国科学院广州生物医药与健康研究院 副研究员；

2013至今 中国科学院广州生物医药与健康研究院 研究员

研究领域：

1.以体细胞重编程等模型研究细胞命运决定的分子调控机理；主要探讨表观遗传调控与信号转导、转录因子之间的联系。

2.以细胞命运转化模型中采集的表观遗传组和单细胞转录组等大数据，通过计算生物学挖掘重要生物学机理。

3.以诱导多能干细胞（iPSC）应用为中心的技术体系开发。

获奖荣誉：

“973”计划首席科学家（青年科学家）；国家自然科学基金优秀青年；广东省自然科学基金杰出青年；广东省科学技术一等奖（第二完成人）。。

代表论著：

1. Chen, J., Liu, H., Liu, J., Qi, J., Wei, B., Yang, J., Liang, H., Chen, Y., Wu, Y., Guo, L., et al. (2013). H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nature Genetics 45, 34-42. （首次阐明H3K9甲基化是重编程的重要障碍，ESI高引论文）

2. Chen, J., Guo, L., Zhang, L., Wu, H., Yang, J., Liu, H., Wang, X., Hu, X., Gu, T., Zhou, Z., et al. (2013). Vitamin C modulates Tet1 function during somatic cell reprogramming. Nature Genetics 45, 1504-1509. （阐明Vc对Tet1的功能的转化作用，当期杂志配发评论）

3. Chen, J., Liu, J., Chen, Y., Yang, J., Chen, J., Liu, H., Zhao, X., Mo, K., Song, H., Guo, L., et al. (2011). Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. Cell Research 21, 884-894.

4. Chen, J., Liu, J., Yang, J., Chen, Y., Chen, J., Ni, S., Song, H., Zeng, L., Ding, K., and Pei, D. (2010). BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Research 21, 205-212.

5. Liu, J.; Han, Q.; Peng, T.; Peng, M.; Wei, B.; Li, D.; Wang, X.; Yu, S.; Yang, J.; Cao, S.; Huang, K.; Hutchins, A. P.; Liu, H.; Kuang, J.; Zhou, Z.; Chen, J.; Wu, H.; Guo, L.; Chen, Y.; Chen, Y.; Li, X.; Wu, H.; Liao, B.; He, W.; Song, H.; Yao, H.; Pan, G.; Chen, J.*; Pei, D.* (2015). The oncogene c-Jun impedes somatic cell reprogramming. Nature Cell Biology 17, 856-867. （*共同通讯作者）

6. Chen, J., and Pei, D. (2012). Reprogramming in suspension. Nature Methods 9, 449-451.

7. Chen, J., Han, Q., and Pei, D. (2012). EMT and MET as paradigms for cell fate switching. J Mol Cell Biol.

8. Wang, Y.,* Chen, J.,* Hu, J.-L., Wei, X.-X., Qin, D., Gao, J., Zhang, L., Jiang, J., Li, J.-S., Liu, J., et al. (2011). Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO reports 12, 373-378. (* co-first author)

9. Chen, T., Shen, L., Yu, J., Wan, H., Guo, A., Chen, J., Long, Y., Zhao, J., and Pei, G. (2011). Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell.

10. Chen, J., Liu, J., Han, Q., Qin, D., Xu, J., Chen, Y., Yang, J., Song, H., Yang, D., Peng, M., et al. (2010). Towards an Optimized Culture Medium for the Generation of Mouse Induced Pluripotent Stem Cells. Journal of Biological Chemistry 285, 31066-31072.

11. Li, R., Liang, J., Ni, S., Zhou, T., Qing, X., Li, H., He, W., Chen, J., Li, F., et al. (2010). A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts. Cell Stem Cell 7, 51-63.

12. Esteban, M.A., Wang, T., Qin, B., Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S., et al. (2009). Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6, 71-79.