陈琳， 博士，教授，广州医科大学南山学者骨干人才，博士毕业于中国科学院生物物理研究所，之后加入药企从事细胞治疗相关研发工作，2018年加入广州医科大学生科院。发表多篇第一作者文章，包括Journal of Hepatology, Cancer Research, American Journal of Pathology等，合计影响因子大于30分，有丰富的肿瘤免疫和细胞治疗领域研究经验，同时具备临床细胞治疗产品开发经验。

研究方向：

宫颈癌等妇科肿瘤的T细胞免疫治疗机制研究

宫颈癌等妇科肿瘤的T细胞免疫治疗方法的开发

免疫检查点抗体与其他治疗方法的联合用药

过往研究经历：

1.T细胞肿瘤免疫治疗研究：

T细胞肿瘤免疫治疗靶点的发现

TCR-T用于治疗肿瘤的体内药效学研究及安全性评价

2.肿瘤微环境研究：

S100A4阳性巨噬细胞在早期肝癌及肝纤维化中的作用

Tie2阳性巨噬细胞在肿瘤化疗后复发中的作用

Publications:

1.-Wang C, Xiong C, Hsu Y, Wang X, Chen L. Human leukocyte antigen (HLA) and cancer immunotherapy: HLA-dependent and -independent adoptive immunotherapies. Ann Blood [Internet]. 2020;5:14–14. Available from: http://aob.amegroups.com/article/view/5744/html

2.-Li Q, Dai C, Xue R, Wang P, Chen L, Han Y, et al. S100A4 protects myeloid-derived suppressor cells from intrinsic apoptosis via TLR4-ERK1/2 signaling. Front Immunol. 2018;9:1–14.

3.-Chen L, Li J, Wang F, Dai C, Wu F, Liu X, et al. Tie2 expression on macrophages is required for blood vessel reconstruction and tumor relapse after chemotherapy. Cancer Res. 2016;76:6828–38.

4.- Chen L, Li J, Zhang J, Dai C, Liu X, Wang J, et al. S100A4 promotes liver fibrosis via activation of hepatic stellate cells. J Hepatol [Internet]. European Association for the Study of the Liver; 2015;62:156–64. Available from: http://dx.doi.org/10.1016/j.jhep.2014.07.035

5.- Sun L, Sun C, Liang Z, Li H, Chen L, Luo H, et al. FSP1+fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells. Sci Rep [Internet]. Nature Publishing Group; 2015;5:1–16. Available from: http://dx.doi.org/10.1038/srep14871

6.- Zhang J, Chen L, Liu X, Kammertoens T, Blankenstein T, Qin Z. Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens. Cancer Res. 2013;73:2770–81.

7.-Li J, Chen L, Qin Z. Multifaceted tumor stromal fibroblasts. Cancer Microenviron. 2012;5:187–93.

8.-Zhang J, Chen L, Xiao M, Wang C, Qin Z. FSP1+fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. Am J Pathol [Internet]. Elsevier Inc.; 2011;178:382–90. Available from: http://dx.doi.org/10.1016/j.ajpath.2010.11.017

9.-Li Z, Chen L, Qin Z. Paradoxical Roles of IL-4 in Tumor Immunity The paradox of IL-4 in tumor immunity. Cell Mol Immunol [Internet]. 2009;2. Available from: https://www.nature.com/articles/cmi200953.pdf