刘兴国， 男，研究员，博士生导师，1980年生。

简历：

1998年-2002年：山东大学生命科学学院，学士

2002年-2006年：清华大学生物科学与技术系，博士

2007年-2010年: Thomas Jefferson University, 博士后

2010年－至今： 中国科学院广州生物医药与健康研究院 研究员

研究领域：

·干细胞命运调控中的核与线粒体等细胞器重塑

·人类线粒体疾病的病理与干细胞治疗

获奖及荣誉：

·国家自然科学“杰出青年“基金

·国家重点研发计划首席科学家

·国家自然科学优秀青年基金

·2016年干细胞青年研究员奖

·广东省自然科学杰出青年基金获得者（首届）

·国际生物物理学会 "2011 Young Bioenergeticist award"

·中国科学院广州教育基地优秀研究生导师

·中国科学院广州分院优秀青年科学家

代表论著：

1. Ying, Z., Xiang G., Zheng, L., …& Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 28(6):935-945.

2. Ying, Z., Chen K., Zheng L., …& Liu, X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism, 23(1): 220-226.

3. Li, L., Chen, K., Wang, T., ……Liu, X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism 2020, 2(9):882-892.

4. Li, S., Guo, J., Ying, Z., ... & Liu, X*. (2015). Valproic acid‐induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5):1730-1739.

5. Wu, Y., Chen, K., Xing, G., …& Liu, X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances, 5(11): eaax7525。

6. Chen, K., Long, Q., Xing, G., …Pei, D*& Liu, X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal, 39(1): e99165 (F1000 recommendation)

7. Xiang, G., Yang, L., Long, Q., …& Liu, X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy, 13(9): 1543-1555.

8. Zhou, Y., Long, Q., Wu, H., …& Liu, X*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy, 16(3):562-574. (Cover Story)

9. Chen, K., Long, Q., Wang, T., … Liu, X* & Pei, D*. (2016) Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Reports,17(11): 1641-1656. (co-corresponding author)

10. Yang, L., Lin, X., Tang, H.,....Liu, X*. (2020).  Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox. Aging Cell 19(9):e13206.

11. Yang, L., Long, Q., Liu, J., ... & Liu, X*. (2015). Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA. Cellular and Molecular Life Sciences, 72(13):2585-2598.

12. Bao, F., Shi, H., Gao, M.,…& Liu, X*. (2018). Polybrene induces neural degeneration by bidirectional Ca2+ influx dependent mitochondrial and ER-mitochondrial dynamics. Cell Death & Disease, 9(10): 966.

13. Li, L., Chen, K., Wu, Y., …& Liu, X*. (2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death Disease, 8(10): e3107.

14. Lin, Y., Xiao, M., Chen, H., Meng, Y., Zhao, N., Yang, L., Tang, H., Wang, J., Liu, X*, Zhu, Y.*, Zhuang, S.*. (2019). A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. Cell Death & Disease, 10(7):528. (co-corresponding author)

15. Wu, Y., Chen, K., Liu, X., ... & Liu, X*. (2015). Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming. Stem Cells, 34(1): 83-92.

16. Yang, L., Tang, H., Lin, X....& Liu, X*. (2020) OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion. Frontiers in Cell and Developmental Biology, 8: 180.

17.Long, Q., Zhao, D., Fan, W., ... Wang X* & Liu, X*. (2015). Modeling of Mitochondrial Donut Formation. Biophysical Journal, 109(5), 892-899. (co-corresponding author)

18. Bao, F., Shi, H., Long, Q., …& Liu, X*. (2016). Mitochondrial Membrane Potential-dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration. CNS Neuroscience & Therapeutics, 22(8), 648-660. (Cover Story)