舒晓东，男，研究员，博士生导师，1972年生

简历：

1989-1993 　复旦大学学士

1993-1996 　北京大学硕士

1996-2002　 美国南加州大学博士

2002-2007 University of California, Los Angeles 博士后

2007－至今 中国科学院广州生物医药与健康研究院 研究员，副研究员

研究领域：

（1）上皮-间充质转换（EMT）在细胞命运调控（胚胎干细胞、肿瘤干细胞）中的作用机制；

（2）上皮细胞极性建立、维持的机制研究及相关疾病模型（炎症性肠病及其它感染性疾病）；

（3）基于EMT及铁死亡通路的药物研发。　　

获奖及荣誉：

实验室研究工作主要得到国家自然科学基金、中科院百人计划、中科院先导专项、国家重大科学研究计划、广东省科技计划等项目的经费支持。

代表论著：

[1] Zhao, S., Xia, J., Wu, X., Zhang, L., Wang, P., Wang, H., Li, H., Wang, X., Chen, Y., Agnetti, J., Li, Y., Pei, D*., and Shu, X*. (2018) Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish, Nat Commun 9, 2639.

[2] Liu, Y., Wu, F., Liu, D., Wei, R., Abbas, N., Xia, J., Li, D., Wang, H., Zhuang, Y., Guo, D., Chen, Y., Wu, Y., Ke, X., Tao, J., Yang, F., Lai, K., Shu, X., and Li, Y. X. (2018) Generation of WAe001-A-15, a human embryonic stem cell line with miR-122 doxycycline-inducible expression, Stem Cell Res 29, 84-87.

[3] Jiang, J., Tang, S., Xia, J., Wen, J., Chen, S., Shu, X., Huen, M. S. Y., and Deng, Y. (2018) C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/beta-catenin signaling, Oncogene 37, 2992-3005.

[4] Cao, S., Yu, S., Li, D., Ye, J., Yang, X., Li, C., Wang, X., Mai, Y., Qin, Y., Wu, J., He, J., Zhou, C., Liu, H., Zhao, B., Shu, X., Wu, C., Chen, R., Chan, W., Pan, G., Chen, J., Liu, J., and Pei, D. (2018) Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency, Cell Stem Cell 22, 529-542 e525.

[5] Xu, J., Zhang, L., Ye, Y., Shan, Y., Wan, C., Wang, J., Pei, D., Shu, X*., and Liu, J*. (2017) SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding, Structure 25, 1251-1263 e1255.

[6] Shan, Y., Liang, Z., Xing, Q., Zhang, T., Wang, B., Tian, S., Huang, W., Zhang, Y., Yao, J., Zhu, Y., Huang, K., Liu, Y., Wang, X., Chen, Q., Zhang, J., Shang, B., Li, S., Shi, X., Liao, B., Zhang, C., Lai, K., Zhong, X., Shu, X., Wang, J., Yao, H., Chen, J., Pei, D., and Pan, G. (2017) PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naive ESCs, Nat Commun 8, 672.

[7] Li, Q., Hutchins, A. P., Chen, Y., Li, S., Shan, Y., Liao, B., Zheng, D., Shi, X., Li, Y., Chan, W. Y., Pan, G., Wei, S., Shu, X*., and Pei*, D. (2017) A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes, Nat Commun 8, 15166.

[8] Cao, S., Yu, S., Chen, Y., Wang, X., Zhou, C., Liu, Y., Kuang, J., Liu, H., Li, D., Ye, J., Qin, Y., Chu, S., Wu, L., Guo, L., Li, Y., Shu, X., Chen, J., Liu, J., and Pei, D. (2017) Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage, J Biol Chem 292, 19122-19132.

[9] Shu, X*., and Pei*, D. (2016) Pluripotency without Proliferation, Cell 164, 595-597. (preview)

[10] Li, C., Ma, W., Yin, S., Liang, X., Shu, X., Pei, D., Egan, T. M., Huang, J., Pan, A., and Li, Z. (2016) Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3, Traffic 17, 500-514.