【个人简介】

胡文祥，广州国家实验室基础研究部研究员，国家重大人才项目入选者（青年）。研究方向为代谢疾病和慢性呼吸系统疾病的遗传与代谢调控机制。相关研究成果以通讯作者（含共同）发表于Nature genetics, Cell Metabolism, Nature Reviews Endocrinology，Nature communications (x4)。中国细胞生物学会细胞代谢分会委员、中国遗传学会大人群健康与常见病分会委员、中国生物物理学会代谢生物学分会青年理事。目前作为课题负责人主持国家重大科技项目和国家自然科学基金面上项目2项。

【研究方向】

慢性呼吸系统和代谢疾病

【科研项目】

1，国家自然科学基金面上项目，2027.1-2030.12，在研，主持                                

2，国家自然科学基金面上项目，2022.11-2026.12，在研，主持                        

3，国家重点研发计划青年项目，2024.12-2029.11，在研，参与        

【代表性论文及著作】

1. Chen Li#, Jie Yao#, Fan Wu#, Leqing Zhu#, Xiaowen Zhang, Lanzhu Peng, Jieda Cui, Su Fang, Li Lin, Wanli Peng, Miao Lei, Mingmeng Fang, Cuihua Wang, Bin Chen, Zongzheng Gui, Xianju Wang, Yubei Jin, Biying Zhu, Chunyan Lu, Qi Wan, Xiaohui Wu, Gaoying Tang, Xinru Ran, Wei Rao, Lei Wang*, Yumin Zhou*, Pixin Ran *, Wenxiang Hu*. Plasma metabolomic signatures enable the diagnosis and prognosis of chronic obstructive pulmonary disease. Nature Communications 2026.

2. Jie Yao#, Su Fang#, Miao Lei#, Zexian Ou, Chuanfei Zeng, Wanli Peng, Na He, Lian Yang, Bingpeng Guo, Mingmeng Fang, Cuihua Wang, Jie Lv, Shuang Wu, Wei Kevin Zhang, Huimin Huang, Yang Peng, Wei Rao, Zhili Rong, Penghui Yang, Chaoqun Wang, Qian Han* & Wenxiang Hu*. Dietary intake and BCAA metabolism regulate pulmonary fibrosis through KDM4A-mediated epigenetic remodeling in male mice. Nature Communications 2026,17:5775.

3. Biying Zhu#, Na He#, Yang Xiao#,*, Bin Chen#, Chen Li#, Ravi Mandla, Yifan Liu, Jiayu Zhang, Xiao Chang, Fulong Yu, Marijana Vujkovic, Julie A. Lynch, Kyong-Mi Chang, VA Million Veteran Program, Bogdan Pasaniuc, Daniel J. Rader, Mitchell A. Lazar* & Wenxiang Hu*. Integrative analyses elucidate transcriptional regulatory functions of risk alleles for metabolic liver disease. Nature genetics 2026, 58(6): 1280-1294.

4. Xianju Wang#, Chen Li#, Zongzheng Gui#, Yubei Jin#, Sijian Xia, Han Zhao, Yifei Wang, Minxian Dai, Suhua He, Yihang Zhong, Xiaozhi Lin, Qiang Xu, Wei Peng, Hongtu Zhao, Jinsai Shang, Haoyue Zhang & Wenxiang Hu*. EBF2 condensates enable adipose thermogenesis through ZFP423 sequestration and epigenetic remodeling. Nature Communications 2026, 17: 5607.

Cuihua Wang, Na He, Shixiang Wang, Miao Lei, Jie Yao, Li Lin, Xue Ding, Jiaman Lin, Yixin Chen, Qiaoyun Long, Hannah Xiaoyan Hui, Liwei Xie, Yun-Shen Chan, Nan Cao, Shanshan Gu* & Wenxiang Hu*. Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms. Nature Communications 2026, 17: 4748.