【个人简介】

广州医科大学联合生命学院教授（南山学者），呼吸疾病全国重点实验室PI。本科毕业于浙江大学，博士毕业于中科院上海生命科学研究院，清华大学免疫所博士后（合作导师刘万里）。主要从事滴鼻疫苗佐剂开发及B细胞等免疫细胞异常活化相关疾病机制研究。以第一/共一作者在《Nature Biomedical Engineering》、《Journal of Experimental Medicine》、《Molecular Therapy》、《Nature Communications》、《Angewandte Chemie International Edition》等国际顶级期刊发表多篇论文并申请专利两项。获得科技部国家重点研发计划项目、国自然面上项目、清北联合生命中心（CLS）博士后基金等项目支持。担任TransMed杂志青年编委并担任多个学术期刊审稿人。

【研究方向】

本课题组长期致力于黏膜免疫、B细胞调控及肿瘤免疫研究，主要方向为：1滴鼻疫苗佐剂开发；2衰老、SLE、AIGA等生理、病理条件下B细胞功能异常的调控机制解析；3新型肿瘤免疫疫苗及佐剂的研发。

【科研项目】

1. 国家自然科学基金面上项目, KDM6B缺失介导的B细胞表观重塑驱动乳酸杆菌富集缓解急性肺损伤的机制研究，2027-1-01至2030-12-31，50万，在研，主持。

2. 国家重点研发计划“揭榜挂帅”项目，新型mRNA疫苗平台体系研究，2022-01-01至2026-12-31，150万，在研，课题骨干。

3. 广州医科大学高水平大学建设“南山学者”骨干人才启动经费，2025-12-05至2030-12-05，300万，在研，主持。

【代表性论文及著作】

一作/共一论文：

1. Li C^#, Li Y^#, Zhou B^#, Li T^#, Wei X^#, Chen K, Chen W, Shi Z, Dai X, Zhang J, Yang C, Ji Z, Sun W, Gao J, Wu J, Zhao B, Min X, Li Y, Lin L, Yang W, Wang M, Liu Z, Liu Y, Zhu C, Yang B, Xu J, Yan L, Shi Y, Lu L, Zhang L, Ding Q9, Xue J, Hou B, Qi H, Liu J*,Yang Y*, Liu D*, Liu W*. Enantiomer-dependent and modification-free DNA matrix as an adjuvant for subunit vaccines against SARS-CoV-2 or pneumococcal infections. Nat Biomed Eng. 2025. (IF=27.7)

2. Li C^#, Wei S^#, Sun D^#, Yang Z^#, Wang Q^#, Lin H, Zhang H, Hu Y, Liu D, Ye D, Tao Y, Liu Z, Xu Z, Li B, Li L, Zhang J, Chen X, Xie N, Shi Y, Liu S, Liu Y, Jiang Y*, Zhu W*, Zhang X*. Development of RelB-targeting small-molecule inhibitors of non-canonical NF-κB signaling with antitumor efficacy. Mol Ther. 2025. (IF=12.1)

3. Li C^#, Zhao M^#, Liu X^#, Li Y^#, Xu Bi^#, Zhou L^#, Sun X^#, Sun W, Kang N, Ji Z, Li T, An H, Wang F, Wu C, Ye J, Zhang J*, Wang Q*, Zhao X*, Li Z*, and Liu W*. Ion channel TRPV2 is critical in enhancing B cell activation and function. J Exp Med. 2024. (IF=12.8)

4. Yang B^#, Zhou B^#, Li C^#, Li X, Shi Z, Li Y, Zhu Y, Zhu C, Li X, Hua Y, Pan Y, He J, Cao T, Sun Y, Liu W, Ge M, Yang Y, Dong Y*, Liu D*. A stable l-DNA hydrogel with improved stability for biomedical applications. Angew Chem Int Ed Engl. 2022. (IF=16.1)

5. Jiang Y^#, Li C^#, Wu Q^#, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F* and Zhang X*. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat Commun. 2019. (IF=14.7)

6. Liu X^#, Li C^#, Wang Y^#, Zhang S*, Liu W*. ZEB2 drives the differentiation of age-associated B cell in autoimmune diseases. Sci Bull (Beijing). 2024. (IF=18.8)

7. Zhou B^#, Li C^#, Liu D*, Liu W*. Chemical strategies and biomedical applications of DNA hydrogels. Fundam Res. 2022. (IF=5.7)

其他论文：

8. Ji Z^#, Gao J^#, Zhang S^#, Li J^#, Wu H^#, Yao J^#, Ma X^#, Xin Y^#, Zhu Y^#, Zhao M^#, Zhao Z, Shen K, Wu T, Qian X, Wang J, An H, Li Y, Sun W, Zhao Q, Zhou X, Gao R, Duan Q, Li C, Geng X, Yang M, Xiao R, Liu J, Wang W, Wang J, Fu Y, Zhang JR, Chen X, Tong P, Cheng G, Qi H, Wu L, Zeng W, Xi Q, Zhang L, Lai Y, Yang W, Zhang Y*, Lu Q*, Liu W*. A metabolic alarmin from keratinocytes potentiates systemic humoral immunity. Nature. 2026. (IF=48.5)

9. Sun W^#, Yang T^#, Sun F^#, Liu P^#, Gao J^#, Lan X^#, Xu W^#, Pang Y, Li T, Li C, Liang Q, Chen H, Liu X, Tan W, Zhu H, Wang F, Cheng F, Zhai W, Kim HN, Zhang J, Zhang L, Lu L*, Xi Q*, Deng G*, Huang Y*, Jin X*, Chen X*, Liu W*. An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms. Nat Immunol. 2024. (IF=27.8)

10. Zhang M^#, Kang N^#, Yu X^#, Zhang X, Duan Q, Ma X, Zhao Q, Wang Z, Wang X, Liu Y, Zhang Y, Zhu C, Gao R, Min X, Li C, Jin J, Cao Q, Liu R, Bai X, Yang H, Zhao L, Liu J, Chen H, Zhang Y, Liu W*, Zheng W*. TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet's disease. Nat Commun. 2024. (IF=14.7)

11. Hu Y^#, Zhang H^#, Xie N, Liu D, Jiang Y, Liu Z, Ye D, Liu S, Chen X, Li C, Wang Q, Huang X, Liu Y, Shi Y, Zhang X*. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Cell Death Differ. 2022. (IF=13.7)

12. Zhang H^#, Hu Y^#, Liu D^#, Liu Z, Xie N, Liu S, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Yan X, Liu Y, Chen CD, Huang X, Eugene Chin Y, Shi Y, Wu B*, Zhang X*. The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes. Cell Death Differ. 2022. (IF=13.7)

13. Liu Z^#, Zhang H^#, Hu Y^#, Liu D, Li L, Li C, Wang Q, Huo J, Liu H, Xie N, Huang X, Liu Y, Chen C D, Shi Y and Zhang X*. Critical role of histone H3 lysine 27 demethylase Kdm6b in the homeostasis and function of medullary thymic epithelial cells. Cell Death Differ. 2020. (IF=13.7)

14. Chen X^#, Wang C^#, Jiang Y, Wang Q, Tao Y, Zhang H, Zhao Y, Hu Y, Li C, Ye D, Liu D, Jiang W, Chin E Y, Chen S, Liu Y, Wang M*, Liu S* and Zhang X*. Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer. Signal Transduct Target Ther. 2020. (IF=40.8)

【团队介绍】

本课题组长期致力于黏膜免疫、B细胞调控及肿瘤免疫研究。课题组与生科院张笑人院长团队共同指导培养，形成大团队协同攻关培养模式；同时与清华大学免疫所、协和病原所、上海交通大学上海市免疫治疗创新研究院、上海中医药大学、中科院脑科学与智能技术卓越创新中心等团队保持密切合作交流，为成员提供一流的培养条件和平台。团队现有博士后1名、硕士生4名，注重多学科交叉与个性化培养。我们常年招收博士后，同时欢迎有志于免疫学研究的研究生、本科生加入团队，共同成长进步。