【个人简介】

袁姣，广州国家实验室研究员/广州医科大学特聘教授，于2015年在中国科学院生物物理研究所取得生物信息学专业博士学位，于2015-2021年在宾夕法尼亚大学医学院从事博士后研究。共发表SCI论文30篇，引用超过2600次，H因子20，其中代表作发表于Cancer Cell, Nature Cancer, Cancer Research, Nucleic Acids Research, Cell Reports, Bioinformatics等杂志，代表性工作包括在泛肿瘤尺度分析和发现人种间异质性特征、发现肿瘤药物适应患者的标志物、筛选靶向治疗和免疫治疗的全新靶点等。近五年内，课题组以生物信息学和肿瘤组学大数据分析为主要研究方法，致力构建以肿瘤多组学数据为基石的生物信息学分析框架，为肿瘤的精准医疗提供分子层面的指南以期加速研究成果的转化。

【学科专业及研究方向】

学科专业：生物信息学

研究方向：1）遗传背景关联的肿瘤异质性研究，2）多组学分析发现抗肿瘤治疗新策略，3）单细胞水平肿瘤异质性研究。

【科研项目】

1. 国家自然科学基金青年项目，基于多组学数据探究东亚人群特异的肿瘤分子特征及治疗策略，2025-01至2027-12，30万，在研，主持。

2. 国家重点研发计划项目, 细胞命运调控的动态多层次研究及其在肿瘤诊疗中的应用，2023-11至2026-10，60万，在研，参与。

【代表性论文及著作】

1．Rongbo Shen#, Meiling Cheng#, Wencang Wang#, Qi Fan, Huan Yan, Jiayue Wen, Zhiyuan Yuan, Jianhua Yao*, Yixue Li*, Jiao Yuan*. Graph domain adaptation-based framework for gene expression enhancement and cell type identification in large-scale spatially resolved transcriptomics. Briefings in Bioinformatics. (2024)

2．Yu Liang#, Qingqing Yuan#, Qijie Zheng, Zilv Mei, Yawei Song, Huan Yan, Jiajie Yang,Shuheng Wu, Jiao Yuan* and Wei Wu*. 2023. DNA Damage Atlas: an atlas of DNA damage and repair. Nucleic Acids Research. Epub ahead of print.

3．Jiao Yuan, Zhongyi Hu, Brandon A. Mahal, Sihai D. Zhao, Kevin H. Kensler, Jingjiang Pi, Xiaowen Hu, Youyou Zhang, Yueying Wang, Junjie Jiang, Chunsheng Li, Xiaomin Zhong, Kathleen T.Montone, Guoqiang Guan, Janos L.Tanyi, Yi Fan, Xiaowei Xu, Mark A.Morgan, Meixiao Long, Yuzhen Zhang,Rugang Zhang, Anil K.Sood, Timothy R.Rebbeck, Chi V.Dang, and Lin Zhang*. 2018. Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers. Cancer Cell. 34(4):549-560.e9.

4．Jiao Yuan#, Kevin H. Kensler#, Zhongyi Hu, Youyou Zhang, Tianli Zhang,Junjie Jiang, Mu Xu, Yutian Pan, Meixiao Long, Kathleen T. Montone, Janos L. Tanyi, Yi Fan, Rugang Zhang, Xiaowen Hu, Timothy R. Rebbeck*,Lin Zhang*. 2020. Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry. PLoS Genetics. 16(2):e1008641.

5．Zhongyi Hu#, Jiao Yuan#, Meixiao Long, Junjie Jiang, Youyou Zhang, Tianli Zhang, Mu Xu, Yi Fan  , Janos L. Tanyi, Kathleen T. Montone, Omid Tavana, Ho Man Chan, Xiaowen Hu *, Robert H. Vonderheide * and Lin Zhang*, The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets, Nature Cancer. 2021 Dec;2(12):1406-1422

6．Junjie Jiang#, Jiao Yuan#, Zhongyi Hu#, Mu Xu, Youyou Zhang, Meixiao Long, Yi Fan,Kathleen T. Montone, Janos L. Tanyi, Omid Tavana, Ho Man Chan, Lin Zhang*, and Xiaowen Hu*. 2022 Jan 1. Systematic Pan-Cancer Characterization of Nuclear Receptors Identifies Potential Cancer Biomarkers and Therapeutic Targets. Cancer Research. 82(1):46-59.  

7．Junjie Jiang#, Jiao Yuan#, Zhongyi Hu#, Youyou Zhang, Tianli Zhang, Mu Xu, Meixiao Long, Yi Fan,Janos L. Tanyi, Kathleen T. Montone, Omid Tavana, Robert H. Vonderheide, Ho Man Chan,Xiaowen Hu*and Lin Zhang*. 2022. Systematic illumination of druggable genes in cancer genomes. Cell Report. 38(8):110400.

8．Weiwei Shan#, Jiao Yuan#, Zhongyi Hu#, Junjie Jiang#, Yueying Wang, Nicki Loo, Lingling Fan, Zhaoqing Tang, Tianli Zhang, Mu Xu, Yutian Pan, Jiaqi Lu, Meixiao Long, Janos L. Tanyi, Kathleen T. Montone, Yi Fan, Xiaowen Hu, Youyou Zhang*, and Lin Zhang*. 2020. Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment. Cell Reports. 32(2):107884.

9．Zhongyi Hu#, Junzhi Zhou#, Junjie Jiang#, Jiao Yuan, Youyou Zhang, Xuepeng Wei, Nicki Loo, Yueying Wang,  Yutian Pan, Tianli Zhang, Xiaomin Zhong, Meixiao Long, Kathleen T. Montone, Janos L. Tanyi, Yi Fan, Tian-Li Wang, Ie-Ming Shih, Xiaowen Hu* & Lin Zhang*. 2019 Feb 13. Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment. Nature Communications. 10(1):733.

10．Jiao Yuan#, Peng Zhang#, Ya Cui, Jiajia Wang, Geir Skogerbø, Da-Wei Huang, Runsheng Chen*, Shunmin He*. 2016. Computational identification of piRNA targets on mouse mRNAs. Bioinformatics. 32(8):1170-7.

【所获荣誉和奖励】

2024入选广东省/市重大人才项目（青年）

2019获得Center for Research on Reproduction and Women's Health/University of Pennsylvania颁发的《Joseph C. Touchstone Award for Excellence in Research》奖项