陈希，广州医科大学生命科学学院生物化学与分子生物学教研室，教授，研究生导师，广州医科大学“南山学者”骨干人才。2016年于上海交通大学医学院获得博士学位，2016-2019年在中国科学院上海营养与健康研究所进行博士后训练，随后加入上海科技大学生命学院任助理研究员。2023年加入广州医科大学生命科学学院。

主持国家自然科学基金青年项目、中国博士后基金面上项目、广州医科大学高水平大学学士骨干人才启动项目。

以第一/通讯（含共同）作者在高水平学术期刊Signal Transduction and Targeted Therapy，Journal of Cell Biology，Cell Death & Disease，International Journal of Biological Science发表多篇文章，国家发明专利1项。

研究方向：肿瘤发生发展与耐药的作用机制和防治策略；

过氧化物酶体的稳态维持分子机制及其在机体中的功能探究。

招生专业为细胞生物学。

邮件：chenxi@gzhmu.edu.cn

发表文章：

1.Chen X^#, Wang C^#, Jiang Y, Wang Q, Zhang H, Zhao Y, Tao Y, Hu Y, Li C, Ye D, Liu D, Jiang W, Eugene Chin Y, Liu Y, Wang M*, Liu S* and Zhang X*. Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer. Signal Transduction and Targeted Therapy. 2020 May 1;5(1):52. (Cover Story).

2.Chen X^#, Wang C^#, Liao K, Zhou S, Cao L, Chen J, Xu C, and Lin Y*. USP17 suppresses tumorigenesis and tumor growth through deubiquitinating AEP. International Journal of Biological Science, 2019; 15(4): 738-748.

3.Chen X^#, Cao X^#, Sun X, Lei R, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, Hou Y, Wang M, Siebenlist U, Eugene Chin Y, Wang Y, Cao L, Hu G*, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death & Disease. 2016 Dec 1;7(12): e2508.

4.Zheng J^#, Chen X^#,*, Liu Q, Zhong G, and Zhuang M*. Ubiquitin ligase MARCH5 locates on peroxisome to regulate pexophagy. Journal of Cell Biology. 2022 Jan 3;221(1):e202103156.

5.Wang Q^#, Chen X^#, Jiang Y^#, Liu S, Liu H, Sun X, Zhang H, Liu Z, Tao Y, Li C, Hu Y, Liu D, Ye D, Liu Y and Zhang X*. Elevating H3K27me3 levels sensitizes colorectal cancer to chemotherapy. Journal of Molecular Cell Biology. 2020 Feb 20;12(2):125-137.

6.Jiang Y, Li C, Wu Q, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F, Zhang X*.Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nature Communications. 2019 Jul 3;10(1):2935. IF:17.694

7.Huo J, Chen X, Zhang H, Hu Y, Jiang Y, Liu S, Zhang X*. Bcl-3 promotes proliferation and chemosensitivity in BL1 subtype of TNBC cells. Acta Biochim Biophys Sin (Shanghai). 2018 Nov 1;50(11):1141-1149. IF:3.5

8.Chen R, Wang L, Liu S, Chen X, Hu Y, Liu H, Zhang H, Jiang Y, Wang Q, Ye D, Li L, Liu D, Pan X, Wei L, Li X, Zhang X*. Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease. Oncotarget. 2017 Oct 9;8(57):97206-97216. IF:4.345

9.Sun X, Liu S, Chen P, Fu D, Hou Y, Hu J, Liu Z, Jiang Y, Cao X, Cheng C, Chen X, Tao Y, Li C, Hu Y, Liu Z, Zhan Y, Mao J, Wang Q, Ma Y, Cong X, Sun R, Shi Y, Wang M, Zhang X*. miR-449a inhibits colorectal cancer progression by targeting SATB2. Oncotarget. 2016 Jul 28;8(60):100975-100988. IF:4.345

10.Liu Z, Cao W, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen CD, Shi Y, Zhang X*. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. Journal of Molecular Cell Biology. 2015 Dec;7(6):505-16. IF: 8.185

11.Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X*. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Gastroenterology. 2014 Oct;147(4):847-859.e11. IF:33.883

12.Lin Y, Qiu Y, Xu C, Liu Q, Peng B, Kaufmann GF, Chen X, Lan B, Wei C, Lu D, Zhang Y, Guo Y, Lu Z, Jiang B, Edgington TS, Guo F*. Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis. J Natl Cancer Inst. 2014 Apr;106(4):dju012. IF:11.876