陈冰洁，女，中共党员。

广州医科大学南山学者“第四层次”骨干人才，教授

电话：134****2537

邮箱: bingjiechen@gzhmu.edu.cn

教育经历

（1）2014-09 至 2019-06, 中山大学, 生物信息学, 博士

（2）2009-09 至 2014-06, 中山大学, 法医学, 学士

工作经历

（1）2019-10 至 2022-09, the Institute of Cancer Research, London, UK

（2）2022-10 至 2023-07, 广州医科大学, 生命科学学院, 讲师

（3）2023-07至今，广州医科大学, 生命科学学院,教授

研究方向

（1）生物信息学、群体遗传学

（2）体细胞及肿瘤演化

（3）肺泡损伤修复

在研项目

（1）国家自然科学基金委，青年科学基金项目  2024-01-01 至 2026-12-31, 在研, 主持

（2）广东省自然科学基金，面上项目 2024-11 至 2027-12-31, 在研,

（3）主持呼吸全国重点实验室，自主课题项目 2024-01-01 至 2026-12-31, 在研, 主持

（4）广州医科大学，高层次人才经费项目-科研启动经费，02-412-2302-2172XM，2023-07 至 2028-7

发表论文（部分）

(1)Bingjie Chen; Xianrui Wu; Yongsen Ruan; Yulin Zhang; Qichun Cai; Luis Zapata; Chung-I Wu; Ping Lan; Haijun Wen ; Very large hidden genetic diversity in one single tumor–Evidence for tumors-in-tumor, National Science Review, 2022, 9(12): nwac250 (Research Article,IF=23.18)

(2)Bingjie Chen, Ramazzotti D, Timon Heide, Inmaculada Spiteri; Claire Lynn, Javier Fernandez-Mateos, Chela James, Luca Magnani; Trevor A. Graham; Andrea Sottoriva. Contribution of pks+ E. coli mutations to colorectal carcinogenesis. Nature Communications. 2023 Nov 29;14(1):7827. (Research Article,IF=16.6)

(3)Bingjie Chen; Zongkun Shi; Qingjian Chen; Xu Shen; Darryl Shibata; Haijun Wen; Chung-I Wu; Tumorigenesis as the Paradigm of Quasi-neutral Molecular Evolution, Molecular Biology and    Evolution, 2019, 36(7): 1430-144(Research Article,IF=11.06)

(4)Kang-Li Li; Yu-Min Liang; Zhi Chen; Pei-Ji Zheng; Guo-Qiang Zhang; Binghua Yan; Mohamed Soliman Elshikh; Humaira Rizwana; BingJie Chen; Qing Xu ; Genome-wide dentification of the alkaloid synthesis gene family CYP450, gives new insights into alkaloid resource utilization in medicinal Dendrobium, International Journal of Biological Macromolecules, 2024, 259:129229

(5)Yongsen Ruan; Haiyu Wang; Bingjie Chen; Haijun Wen; Chung-I Wu ; Mutations Beget More Mutations—Rapid Evolution of Mutation Rate in Response to the Risk of Runaway Accumulation, Molecular Biology and Evolution, 2019, 37(4): 1019   (期刊论文)

(6)Timon Heide; Jacob Househam; George D. Cresswell; Inmaculada Spiteri; Claire Lynn; Maximilian Mossner; Chris Kimberley; Javier Fernandez-Mateos; Bingjie Chen; Luis Zapata; Chela James; Iros Barozzi; Ketevan Chkhaidze; Daniel Nichol; Vinaya Srirangam Nadhamuni; Alison Berner; Melissa Schmidt; Eszter Lakatos; Ann-Marie Baker; Helena Costa; Miriam Mitchinson; Rocco Piazza; Marnix Jansen; Giulio Caravagna; Daniele Ramazzotti; Darryl Shibata; John Bridgewater; Manuel Rodriguez-Justo; Luca Magnani; Trevor A. Graham; Andrea Sottoriva ; The co-evolution of the genome and epigenome in colorectal cancer, Nature, 2022, 611(7937): 733-743   (期刊论文)

(7)Jacob Househam; Timon Heide; George D. Cresswell; Inmaculada Spiteri; Chris Kimberley; Luis Zapata; Claire Lynn; Chela James; Maximilian Mossner; Javier Fernandez-Mateos; Alessandro Vinceti; Ann-Marie Baker; Calum Gabbutt; Alison Berner; Melissa Schmidt; Bingjie Chen; Eszter Lakatos; Vinaya Srirangam Nadhamuni; Daniel Nichol; Helena Costa; Miriam Mitchinson; Daniele Ramazzotti; Benjamin Werner; Francesco Iorio; Marnix Jansen; Giulio Caravagna; Chris P. Barnes; Darryl Shibata; John Bridgewater; Manuel Rodriguez-Justo; Luca Magnani; Andrea Sottoriva; Trevor

A. Graham ; Phenotypic plasticity and genetic control in colorectal cancer evolution, Nature, 2022, 611(7937): 744-753   (期刊论文)

(8)Chung-I Wu; Haijun Wen; Jian Lu; Xiaodong Su; Alice C Hughes; Weiwei Zhai; Chen Chen; Hua Chen; Mingkun Li; Shuhui Song; haohuiQian Z; Qihui Wang; Bingjie Chen; Zixiao Guo; Yongsen Ruan; Xuemei Lu; Fuwen Wei; Li Jin; Le Kang; Yongbiao Xue; Guoping Zhao; Yaping Zhang; On the origin of SARS-CoV-2-The blind watchmaker argument, Science China. Life Sciences, 2021, 64(9): 1560-1563 (期刊论文)