【个人简介】

肖雅方，博士，广州医科大学南山学者副教授，硕士生导师。主要研究领域为纳米药物智能递送与分子影像在疾病诊断和治疗中的应用，具体包括设计合成近红外智能荧光成像探针、多功能光学共轭寡聚物和有机光敏剂；设计开发智能纳米药物递送系统与精准成像系统等。目前已在Nature Review Bioengineering, Advanced Science， Small， Chemical Engineering Journal， Chemical Science以及CCS Chemistry等国内外高水平期刊上发表SCI论文40多篇，其中以第一/通讯作者发表高水平国际论文十余篇，有3篇论文入选ESI高被引论文，H指数24，论文他引近千次。主持承担国家自然科学基金青年项目，广州市科技局青年博士“启航”项目等项目，申请多项美国专利与国内专利。

【研究方向】

1.纳米核酸药物智能递送与载体分子设计

2.智能光功能分子的开发用于疾病的光学诊疗

3.多功能纳米载体设计用于疾病免疫治疗

【科研项目】

1.近红外光触发中性粒细胞介导时空可控的自增强靶向和激活型肝癌光动力治疗探究，202401-202612，国家自然科学基金青年项目，在研，主持。

2.日光激发下具有多重ROS响应的氧气增敏型智能水凝胶用于糖尿病足溃疡的光动力治疗，20240401-20260331，广州市科技局2024年度基础与应用基础研究专题，在研，主持。

【代表性论文及著作】

1.Y. Xiao, Y. Huang*, M. Xie, M. Yang, Y. Tao, L. Liu, J. Wu, G. Xie, J. Liu, T. Xu, W. Guo*, X.-J. Liang*, Immunoregulatory Nanomedicine for Respiratory Infections. Nature Review Bioengineering 2023. DOI:10.1038/s44222-023-00131-8.

2.C. Fu, Q. Li, M. Li, J. Zhang, F. Zhou, Z. Li, D. He, X. Hu, X. Ning, W. Guo, W. Li, J. Ma, G. Chen, Y. Xiao*, C. Ou*, W. Guo*, An Integrated Arterial Remodeling Hydrogel for Preventing Restenosis After Angioplasty. Advanced Science 2024. 2307063. (IF=15.1)

3.Z. Guan, J. Hu, S. Li, Y. Liu, X. Zhang, J. Liu, H. Chen, F. Liao, H. Sun, G. Hou, W. Guo*, Y. Xiao*, J. Chen*, Self-enhanced targeted nanomedicines based on iron starvation acclimation for tumor-specific therapy. Chemical Engineering Journal, 2024, 495, 153371. (IF=15.1)

4.J. Zhang, J. Hu, W. Zhu, Y. Liu, S. Li, H. Chen, F. Liao, Q. Zhang, X. Sun, X. Li, Y. Xiao*, J. Chen*, Hypoxia-Triggered Tumor Specific Glutamine Inhibition for Reversing Cisplatin Resistance of Chemotherapy. Chemical Engineering Journal, 2024, 479, 147692. (IF=15.1)

5.Y. Xiao, C. Xiang, S. Li, C. Mao, H. Chen, J.-X. Chen, S. Tian, X. Cui, Y. Wan, Z. Huang, X. Li, X.-H. Zhang*, W. Guo*, C.-S. Lee*, Single-Photomolecular Nanotheranostics for Synergetic Near-Infrared Fluorescence and Photoacoustic Imaging-Guided Highly Effective Photothermal Ablation. Small 2020, 16, 2002672. (IF=13.3)

6.Y. Xiao, F.-F. An*, J.-X. Chen, J. Yu, W.-W Tao, Z. Yu, R. Ting, C.-S. Lee, X.-H. Zhang*, The Nanoassembly of an Intrinsically Cytotoxic Near-Infrared Dye for Multifunctionally Synergistic Theranostics. Small 2019, 15, 1903121. (IF=13.3)

7.Y. Xiao, J.-X. Chen, S. Li*, W.-W Tao, S. Tian, K. Wang, X. Cui, Z. Huang, X.-H. Zhang*, C.-S. Lee*, Manipulating exciton dynamics of thermally activated delayed fluorescence materials for tuning two-photon nanotheranostics. Chemical Science. 2020,11, 888-895. (IF=8.4)

8.Y. Xiao, W-C. Chen, J-X. Chen, G-H. Lu*, S. Tian, X. Cui, Z. Zhang, H. Chen, Y. Wan, S. Li*, C.-S. Lee*, Amplifying Free Radical Generation of AIE Photosensitizer with Small Singlet-Triplet Splitting for Hypoxia-Overcoming Photodynamic Therapy. ACS Applied Materials & Interfaces. 2022, 14, 4, 5112–5121. (IF=9.5)

9.Y. Xiao, J.-X. Chen, W.-C. Chen, X. Zheng, C. Cao, J. Tan, X. Cui, Z. Yuan, S. Ji, G. Lu*, W. Liu, P. Wang, S. Li*, C.-S. Lee*, Achieving high singlet-oxygen generation by applying the heavy-atom effect to thermally activated delayed fluorescent materials. Chemical Communications. 2021, 57, 4902-4905. (IF=4.9)

10.Q. Long, Y. Yang, F. Liao, H. Chen, D. He, S. Li, P. Li, W. Guo, Y. Xiao*, NIR-II Fluorescence and PA Imaging Guided Activation of STING Pathway in Photothermal Therapy for Boosting Cancer Immunotherapy by Theranostic Thermosensitive Liposomes. Journal of Materials Chemistry B, 2023, 11 (35), 8528–8540. (IF=7.0)

【所获荣誉和奖励】

1.2023年荣获广州市卫生健康委员会优秀人才称号;

2.2020年荣获香港城市大学优秀科研奖