【个人简介】

李卫，研究员，博士生导师，广州市妇女儿童医疗中心PI，优生围产研究所负责人。国家杰出青年基金获得者，科技部”中青年科技创新领军人才”入选者，国家重点研发计划、自然科学基金重大研究计划重点项目负责人。1998年和2003年于兰州大学获得学士及博士学位。2003年8月至2009年5月分别在清华大学生物科学与技术系和美国国立健康研究院NIDDK从事博士后研究。2009年中国科学院百人计划引进海外杰出人才，2021年12月担任广州妇女儿童医疗中心优生围产研究所负责人。李卫研究员主要从事生育力维持与重塑方面的研究，从干细胞维持与分化、减数分裂、配子成熟和体细胞-生殖细胞互作四方面系统深入地解析了不孕不育的发病机理，从而为生殖和衰老相关疾病的诊治提供新的靶点和思路。迄今已在Nature、Mol Cell、Adv Sci、Nat Commun、J Cell Biol、Am J Hum Genet、EMBO J、PNAS、Cell Res、Nucleic Acids Res、Autophagy、Cell Death Differ等杂志发表论文150余篇。担任动物学会生殖生物学委员会常委、中国妇幼保健协会生育力保存专业委员会常委、细胞生物学会细胞器生物学分会秘书长等职务，荣获教育部科技进步二等奖、妇幼健康研究会自然科学一等奖。

邮箱：leways@gwcmc.org

【研究方向】

1）配子发生尤其是减数分裂的翻译后修饰调控。

2）组蛋白修饰在配子发生以及干细胞维持和分化中的功能和作用机制。

3）生殖衰老相关疾病的分子基础。

4）生育力维持与重塑的新方法和新途径。

【科研项目】

1. 国家自然科学基金（重点项目），R-loop在配子发生中的作用机制研究，2023-01-01至2027-12-31，266万，主持。

2. 国家自然科学基金（杰出青年）,男性不育致病机理，2020-01-01至2024-12-31，400万，主持。

3. 国家重点研发计划，父源遗传物质调控机理及其对子代健康的影响--父源遗传物质缺陷影响子代健康的作用机理，2024-12至2027-11，62.39万，研究骨干。

4. 国家重点研发计划，精子发生障碍的干预新策略--精子发生障碍临床预防诊治的应用及推广，2022-12至2025-11，75万，课题骨干。

【代表性论文及著作】

1. Wei H, Song Q, Wang L, Deng Q, Wu B, Chen Y, Han T, Guo Y, Li Z, Dong F, Ma S, Zhao Q, Shi X, Pan C, Jiang W, Liu X, Chen Y, Jiao R*, Yuan L*, Liu C*, Guo X*, Cong Y*, Li W*. PDCD5 promotes substrate release from the TRiC complex in cilia and flagella. Mol Cell. 2026 Jan 22;86(2):376-392.e11. doi: 10.1016/j.molcel.2025.12.012.

2. Tan T, Zhao Y, Chen Y, Mi Y, Zeng J, Du P, Han T, Liu Y, Li N, Kong J, Wang L, Yu Y, Li MJ, Zhang L*, Li W*, Liu C*. Ufd2p promotes efficient crossover formation by destabilizing Top2p during meiosis. Proc Natl Acad Sci U S A. 2026 Feb 10;123(6):e2517398123. doi: 10.1073/pnas.2517398123

3. Li J, Zhang R, Zeng X, Xu W, Gao L, He S, Wu B, Ma Y, Nie Y*, Shirakawa J*, Xia H*, Li W*. Imeglimin ameliorates MASLD by targeting PEN2 to activate AMPK pathway. Metabolism. 2026 Feb;175:156458. doi: 10.1016/j.metabol.2025.156458.

4. Chen Y, Wang L, Zhou Q, Wei W, Wei H, Ma Y, Han T, Ma S, Huang X, Zhang M*, Gao F*, Liu C*, Li W*. Dynamic R-loops at centromeres ensure chromosome alignment during oocyte meiotic divisions in mice. Sci Bull (Beijing). 2025 Apr 30;70(8):1311-1327. doi: 10.1016/j.scib.2025.02.009.

5. Wang L, Liu C, Li L, Wei H, Wei W, Zhou Q, Chen Y, Meng TG, Jiao R, Wang ZB*, Sun QY*, Li W*. RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles. Adv Sci (Weinh). 2024 Apr;11(13):e2306986. doi: 10.1002/advs.202306986

6. Dong F, Wang X, Huang T, Yin Y, Xiao S, Ma Y, Wei H, Wu B, Zhang R, Wang L, Guo X, Gao F, Liu C, Liu H*, Zhao J*, Li W*. CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice. Genes Dis. 2023 Sep 29;11(6):101132. doi: 10.1016/j.gendis.2023.101132.

7. Liu C, Wang L, Li Y, Guo M, Hu J, Wang T, Li M, Yang Z, Lin R, Xu W, Chen Y, Luo M, Gao F, Chen JY, Sun Q, Liu H, Sun B*, Li W*. RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis. Nucleic Acids Res. 2023 Aug 11;51(14):7357-7375. doi: 10.1093/nar/gkad524.

8. Yang B, Liu C, Ju X, Wu B, Wang Z, Dong F, Yu Y, Hou X, Fang M, Gao F, Guo X, Gui Y*, Ding Q*, Li W*. A tissue specific-infection mouse model of SARS-CoV-2. Cell Discov. 2023 Apr 20;9(1):43. doi: 10.1038/s41421-023-00536-0.

9. Liu W, Chen M, Liu C, Wang L, Wei H, Zhang R, Ren Z, Chen Y, Luo M, Zhao J, Jiang H*, Gao F*, Li W*. Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells. Autophagy. 2023 Feb;19(2):644-659. doi: 10.1080/15548627.2022.2094671.

10. Liu B, Liu C, Ma B, Zhang R, Zhao Z, Xiao S, Cao W, Ma Y, Zhu G, Li W*, Li Z*. PA1 participates in the maintenance of blood-testis barrier integrity via cooperation with JUN in the Sertoli cells of mice. Cell Biosci. 2022 Apr 4;12(1):41. doi: 10.1186/s13578-022-00773-y..

11. Wang L, Liu C, Yang B, Zhang H, Jiao J, Zhang R, Liu S, Xiao S, Chen Y, Liu B, Ma Y, Duan X, Guo Y, Guo M, Wu B, Wang X, Huang X, Yang H, Gui Y, Fang M, Zhang L*, Duo S*, Guo X*, Li W*. SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity. J Cell Biol. 2022 Jul 4;221(7):e202108015. doi: 10.1083/jcb.202108015.

12. Liu C, Liu H, Zhang H, Wang L, Li M, Cai F, Wang X, Wang L, Zhang R, Yang S, Liu W, Liang Y, Wang L, Song X, Su S, Gao H, Jiang J, Li J, Luo M, Gao F, Chen Q, Li W*, Chen ZJ*. Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans. EMBO J. 2021 Jul 1;40(13):e106864. doi: 10.15252/embj.2020106864.

13. Khawar MB, Liu C, Gao F, Gao H, Liu W, Han T, Wang L, Li G*, Jiang H*, Li W*. Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy. Protein Cell. 2021 Jan;12(1):67-75. doi: 10.1007/s13238-020-00771-1

14. Liu C, Zhao HC, Xiao S, Han T, Chen Y, Wang T, Ma Y, Gao H, Xie Z, Du L, Li J, Li G*, Li W*. Slx5p-Slx8p promotes accurate chromosome segregation by mediating the degradation of synaptonemal complex components during meiosis. Adv Sci (Weinh). 2020 Jan 1;7(4):1900739. doi: 10.1002/advs.201900739.

15. Hua R, Wei H, Liu C, Zhang Y, Liu S, Guo Y, Cui Y, Zhang X, Guo X, Li W*, Liu M*. FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis. Nucleic Acids Res. 2019, Vol. 47, No. 22 11755-11770

16. Zhu F, Liu C, Wang F, Yang X, Zhang J, Wu H, Zhang Z, He X, Zhang Z, Zhou P, Wei Z, Shang Y, Wang L, Zhang R, Ouyang YC, Sun QY, Cao Y*, Li W*. Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome. Am J Hum Genet. 2018 Aug 2;103(2):188-199.

17. Liu C, Song Z, Wang L, Yu H, Liu W, Shang Y, Xu Z, Zhao H, Gao F, Wen J, Zhao L, Gui Y, Jiao J, Gao F, Li W*. Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice. Development. 2017 Feb 1;144(3):441-451.

18. Shang YL, Wang HN, Jia PF, Zhao HC, Liu C, Liu WX, Song ZH, Xu ZL,Yang L, Wang YF, Li W*. Autophagy regulates spermatid differentiation via degradation of PDLIM1. Autophagy. 2016 Sep;12(9):1575-92. doi: 10.1080/15548627.2016.1192750.

19. Li W^#, Tu D^#, Li LY, Wollert T, Ghirlando R, Brunger AT, Ye Y. Mechanism of ubiquitin chain assembly on the active site cysteine of the ubiquitin conjugating enzyme Ube2g2. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3722-7.

20. Li W, Tu D, Brunger A, Ye Y. (2007) An ubiquitin ligase transfers preformed polyqubiquitin chains from a conjugating enzyme to substrate. Nature 446(7133):333-7.