姜桔红,女,研究员,2001-2004年在中山大学附属肿瘤医院肿瘤攻读博士学位。2004-2007年在中山大学附属第一医院博士后研究,2007-2011年在美国范德堡大学肿瘤中心博士后研究。2011年9月至今在广州医科大学附属第一医院病理科和呼吸病理中心工作,从事临床病理诊断和科研工作。主要擅长胸部疾病(包括气道、肺部、胸膜及纵膈)肿瘤性和非肿瘤性病变的病理诊断。研究方向为乳腺癌易感基因BRCA1的功能调节与DNA损伤修复;肺癌靶向治疗的分子检测。先后发表SCI论文十几篇,代表性论文发表在Cancer Research, Lung Cancer等。回国后承担国家自然科学基金面上项目两项(编号:81272901,2013-2016;编号:81772814,2018-2021)。可招收病理与病理生理学学术型研究生或临床病理专业型研究生。
科研项目:
1.国家自然科学基金,面上项目,编号:81272901,以染色体断裂同源重组修复为靶点增高乳腺癌细胞对 PARP1 抑制剂的敏感性,2012/01-2016/12,80万元,主持,已结题
2. 国家自然科学基金,面上项目,编号:81772814,p53依赖的放射诱导BRCA1出核增强PARP抑制剂敏感性研究, 2018/01-2021/12,55万元,主持,在研
近期发表的文章:
1. Yuqin Li, Yingying Gu, Cheng Hong, Yu Deng, Zhucheng Chen, Juhong Jiang. Pulmonary capillary hemangiomatosis in Chinese patients without EIF2AK4. Pathology - Research and Practice 216 (2020) 153100 (通讯作者;SCI影响因子: 2.05)
2. Jing Liu, Xuanzhi Liao, Yingying Gu, Lin Fu, Jin Zhao, Longguang Li, Zhucheng Chen, Juhong Jiang*. Role of p16 deletion and BAP1 loss in the diagnosis of malignant mesothelioma. J Thorac Dis 2018;10(9):5522-5530(通讯作者;SCI影响因子: 2.02)
3. Xinguan Yang#, Juhong Jiang# , Xiao Dong, Jiamin Liang, Yubao Guan. Correlations between computed tomography and positron emission tomography/computed tomography findings and pathology in 6 cases of pulmonary epithelioid angiosarcoma. Medicine. 2018.97:35(e12107) (共同第一作者;SCI影响因子: 2.03)
4. Fu X#, Jiang J#, Li B, Tian XY, Li Z.Cecal Endometriosis With Intestinal Metaplasia Misdiagnosed as Neoplasm of the Cecum by Intraoperative Histological Examination. Int J Surg Pathol. 2018 Feb;26(1):24-30. (共同第一作者;SCI影响因子: 1.2)
5. Jiang J, Lu Y, Li Z, Li L, Niu D, Xu W, Liu J, Fu L, Zhou Z, Gu Y, Xia F. Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery. Investigational New Drugs. 2017 Jun;35(3):251-259. (SCI影响因子: 3.84)
6. Jiang J, Gu Y, Liu J, WU R, Fu L, Zhao J, Guan Y, Coexistence of p16/CDKN2A homozygous deletions and activating EGFR mutations in lung adenocarcinoma patients signifies a poor response to EGFR-TKIs, Lung Cancer,2016.12.01,102(12):101-107, (SCI影响因子: 4.59)
7. Fu X, Jiang J*, Tian XY, Li Z. Pulmonary epithelioid inflammatory myofibroblastic sarcoma with multiple bone metastases: case report and review of literature. Diagn Pathol. 2015 Jul 16; 10:106. (通讯作者;SCI影响因子: 2.08)
8. Fu X, Jiang J, Luo BN, Tian XY, Li Z. Intraspinal dural-based primary osteoblastoma with aneurysmal bone cyst-like change. Neuropathology. 2014 Oct; 34(5):510-5. (SCI影响因子: 1.78)
9. Fu X, Jiang JH, Tian XY, Li Z. Isolated spinal Rosai-Dorfman disease misdiagnosed as lymphoplasmacyte-rich meningioma by intraoperative histological examination. Brain Tumor Pathol. 2015 Jan; 32(1):72-5. (SCI影响因子: 1.54)
10. Jiang J, Xie D, Zhang W, Xiao G, Wen J, Fusion of Hsp70 to Mage-a1 enhances the potency of vaccine-specific immune responses, Journal of Translational Medicine, 2013.12.5,11(300), (SCI影响因子: 3.78)
11. Fu X, Jiang JH*, Gu X, Li Z. Malignant perivascular epithelioid cell tumor of mesentery with lymph node involvement: a case report and review of literature. Diagn Pathol. 2013 Apr 15; 8:60. (SCI影响因子: 2.08)
12. Jiang J, Yang ES, Jiang G, Nowsheen S, Wang H, Wang T, Wang Y, Billheimer D, Chakravarthy AB, Brown M, Haffty B, Xia F. p53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage. Cancer Res. 2011 Aug 15; 71(16):5546-57(SCI影响因子: 9.12)
13. Wang H, Yang ES, Jiang J, Nowsheen S, Xia F. DNA damage-induced cytotoxicity is dissociated from BRCA1's DNA repair function but is dependent on its cytosolic accumulation. Cancer Res. 2010 Aug 1; 70(15):6258-67. (SCI影响因子: 9.12)