宣爱国，男，博士，教授，博士后合作导师、博士生导师，南山学者。广东省优秀青年教师培养对象，广州市高层次人才，国家重大科技培育项目、国家自然科学基金评审专家，博士毕业于南方医科大学，师从于高天明院士。

研究兴趣为神经发育异常与认知障碍的关系及其机制的研究，着重围绕表观遗传学修饰与神经元再生、神经退行性疾病发生的关系等方面展开基础研究。近年主持国家自然科学基金2项及13项省市厅级课题。

电子邮件：xag2005@163.com

近五年部分代表性通讯作者论文：

1. Kong X#, Gong Z#, Zhang L#, Sun X#, Ou Z, Xu B, Huang J, Long D, He X, Lin X, Li Q, Xu L,Xuan A*.JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation.Brain Behav Immun. 2019;79:159-173.(IF= 19.227)

2. Ou Z#, Kong X#, Sun X#, He X#, Zhang L, Gong Z, Huang J, Xu B, Long D, Li J, Li Q, Xu L,Xuan A*.Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice.Brain Behav Immun.2018;69:351-363.(IF= 19.227)

3. Ye X#, Wu Y#, Xu J#, Liu H#, Wang H, Li Q, Li Q,Xuan A*. PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation.Pharmacol Res. 2022;179:106235.(IF= 10.334)

4. Gong Z#, Huang J#, Xu B#, Ou Z#, Zhang L, Lin X, Ye X, Kong X, Long D, Sun X, He X, Xu L, Li Q,Xuan A*.Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice.J Neuroinflammation. 2019;16(1):62.(IF= 9.587)

5. Zhang X#, He X#, Li Q#, Kong X, Ou Z, Zhang L, Gong Z, Long D, Li J, Zhang M, Ji W, Zhang W, Xu L,Xuan A*. PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications.Stem Cell Reports.2017;8(5):1256-1269.(IF= 7.765)

6. Zhang L#, Li Q#, Wang H#, Wu Y#, Ye X, Gong Z, Li Q,Xuan A*.Gadd45g, a novel antidepressant target, mediates metformin-induced neuronal differentiation of neural stem cells via DNA demethylation.Stem Cells, 2022,40(1):59-73.(IF= 7.871)

7. Xu B#, Li Q#, Wu Y#, Wang H#, Xu J, Liu H,Xuan A*.Mettl3-mediated m6A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects.FASEB J. 2022;36(7):e22392.(IF= 5.834)

8. Guan YF#, Huang GB#, Xu MD, Gao F, Lin S, Huang J, Wang J, Li YQ, Wu CH, Yao S, Wang Y, Zhang YL, Teoh JP,Xuan A*,Sun XD*.Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula.Brain Behav Immun.2020;88:748-762.(IF= 19.227)

9. Lin XH#, Ye XJ#, Li QF, Gong Z, Cao X, Li JH, Zhao ST, Sun XD, He XS*,Xuan AG*.Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice.Neuroscience. 2020;448:94-106.(IF= 3.59)

10. Liao W, Luo H, Ruan Y, Mai Y, Liu C, Chen J, Yang S,Xuan A*, Liu J*. Identification of candidate genes associated with clinical onset of Alzheimer's disease.Front Neurosci. 2022;16:1060111.(IF= 5.151)

11. Li Q#, Wang X#, Wang ZH#, Lin Z, Yang J, Chen J, Wang R, Ye W, Li Y, Wu Y*,Xuan A*.Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice.Hum Vaccin Immunother. 2022 Sep 16:2121568.(IF= 4.525)