陈鑫，男，博士，副研究员，硕士研究生导师。

单位：广州医科大学，基础医学院，病理生理学教研室，广东省蛋白质修饰与降解重点实验室。

招生专业：病理学与病理生理学

电子邮件：chenxin532@126.com

研究方向：1.细胞死亡新型调控机制及相关药物研发；2.铁死亡与疾病

所获荣誉和奖项

1.广州医科大学南山学者

2. 2020年教育部高等学校科学研究优秀成果奖（科学技术）自然科学奖二等奖

3. 2016年广州市科学技术奖励一等奖

留学经历：2018.12-2020.12美国德克萨斯大学西南医学中心（UTSW）访问学者。

主持科研项目：主持国家自然科学基金项目及省市级课题多项。

部分代表性第一和通讯作者论文：

1.Chen X#, Huang J, Yu C, Liu J, Gao W, Li J, Song X, Zhou Z, Li C, Xie Y, Kroemer G, Liu J#, Tang D#, Kang R#. A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis.Nature Communications, 2022, 13(1):6318. (Editors' Highlight [编辑亮点论文]；IF: 17.694)

2.Chen X#, Song X, Li J, Zhang R, Yu C, Zhou Z, Liu J, Liao S, Klionsky D, Kroemer G, Liu J#, Tang D#, Kang R#. Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis.Autophagy, 2022, 19(1):54-74. (IF: 13.391)

3.Chen X, Kang R, Kroemer G#, Tang D#. Broadening horizons: the role of ferroptosis in cancer.Nature Reviews Clinical Oncology, 2021, 18(5): 280-296. (高被引论文；热点论文；IF: 65.011)

4.Chen X, Kang R, Zeh H, Kroemer G#, Tang D#. Cell death in pancreatic cancer: from pathogenesis to therapy.Nature Reviews Gastroenterology & Hepatology, 2021, 18(11): 804-823. (高被引论文；IF: 73.082)

5.Chen X, Yu C, Kang R, Kroemer G#, Tang D#. Cellular degradation systems in ferroptosis.Cell Death & Differentiation, 2021, 28(4): 1135-1148. (高被引论文；IF:12.067)

6.Chen X, Comish PB, Tang D#, Kang R#. Characteristics and biomarkers of ferroptosis.Frontiers in Cell and Developmental Biology, 2021, 9: 637162. (高被引论文；IF:6.081)

7.Chen X, Li J, Kang R, Klionsky D, Tang D#. Ferroptosis: machinery and regulation.Autophagy, 2020,17(9): 2054-2081. (高被引论文；IF: 13.391)

8.Chen X, Yu C, Kang R, Tang D#. Iron metabolism in ferroptosis.Frontiers in Cell and Developmental Biology, 2020, 8: 590226. (高被引论文；IF:6.081)

9.Chen X, Kang R, Kroemer G#, Tang D#. Ferroptosis in infection, inflammation, and immunity.Journal of Experimental Medicine. 2021, 218(6): e20210518. (高被引论文；IF:17.579)

10.Chen X, Kang R#, Kroemer G#, Tang D#. Organelle-specific regulation of ferroptosis.Cell Death & Differentiation, 2021, 28(10): 2843-2856. (IF:12.067)

11.Chen X, Kang R#, Kroemer G#, Tang D#. Targeting ferroptosis in pancreatic cancer: a double-edged sword.Trends in Cancer, 2021, 7(10): 891-901.(IF: 19.161)

12.Yan D*, Li X*, Yang Q, Huang Q, Yao L, Zhang P, Sun W, Lin S, Dou Q, Liu J#,Chen X#. Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.Cell Death Discovery. 2021, 7(1): 211. (IF:7.109)

13.Wu S*, Zhu C*, Tang D, Dou Q, Shen J#,Chen X#. The role of ferroptosis in lung cancer.Biomarker Research, 2021, 9(1): 1-14. (IF:8.633)

14.Xue Q, Yan D, Chen X, Li X, Kang R, Klionsky D, Kroemer G,Chen X#, Tang D#, Liu J#. Copper-dependent autophagic degradation of GPX4 drives ferroptosis.Autophagy, 2023. (IF: 13.391)

15.Yang Q*, Yan D*, Zou C, Xue Q, Lin S, Huang Q, Li X, Tang D,Chen X#, Liu J#. The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability.Experimental & Molecular Medicine, 2022, 54(11): 2047-2059. (IF:12.153)

* These authors contributed equally to the work.

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