个人概况

姓名：赵磊        性别：女

职称：教授        导师资格：硕士生导师

单位：广州医科大学基础医学院生理教研室

学历：博士        毕业院校：中山大学

招生专业：生理学及病理生理学

电子邮件：zhaolei@gzhmu.edu.cn和crystal-zl@163.com

通信地址：广州医科大学基础医学院生理教研室

研究方向

呼吸生理学及病理生理学的基础机制和临床治疗以及人工智能在呼吸系统疾病中的应用

所获荣誉

1. 2013 年度广州市出国（境）培训优秀学员

2. 2018年度广州医科大学最受学生欢迎教师

指导学生获得的科研项目和奖项

1. 2017年指导学生获得广州医科大学“挑战杯”大学生课外科技作品竞赛一等奖

2. 2017年指导学生获得广东省“挑战杯”大学生课外科技作品竞赛三等奖

3. 2017年指导学生参加中国国际心血管病学术会议获三等奖

4. 2017年指导学生参加世界肺癌大会获得国际肺癌研究协会Country Travel Award winner

5. 2018年指导学生参加“医带医路”凯瑞菁英赛获得中国医疗保健国际交流促进会东赛区冠军

6. 2019年指导学生参加世界肺癌大会获得壁报奖

主持科研项目

1. 国家级项目1项：国家自然科学基金， nAchRs-PI3K/Akt-TRPC 信号通路在香烟烟雾暴露致 PAH 中的调控机制，结题，23万。

2. 省级1项：广东省科技厅， HIF-1/BMP4-TRPC 信号通路在香烟烟雾致 PAH 中的作用机制，结题，5万。

3. 厅级2项：广东省教育厅，TRPC-NFAT 信号通路在尼古丁诱发肺动脉高压过程中的机制，结题，3万。广东省卫生厅，nAchRs-TRPC-NFAT 信号通路在香烟烟雾诱发肺动脉高压过程中的机制，结题，2万。

部分代表性论文：

1. Zhang YL, Zhang RG, Chen FY, Qiu ZE, Chen L, Huang ZX, Huang J, Zhu YX, Zhao L(co-corresponding author), Zhou WL. Cellular mechanism underlying the facilitation of contractile response induced by tumor necrosis factor-α in mouse tracheal smooth muscle.Am J Pathol. 2022 Jan;192(1):104-111. doi: 10.1016/j.ajpath.2021.10.007. Epub 2021 Oct29.PMID: 34756873(IF=3.853)

2. Liu Z, Lin G, Yan Z, Li L, Wu X, Shi J, He J, Zhao L*( co-corresponding author), Liang H, Wang W.Predictive mutation signature of immunotherapy benefits in NSCLC based on machine learning algorithms.Front Immunol. 2022 Sep 27;13:989275. doi10.3389/fimmu.2022.989275. eCollection 2022. (IF=8.786)

3. Zhuo-Er Qiu, Jian-Bang Xu , Lei Chen , Ze-Xin Huang , Tian-Lun Lei, Zi-Yang Huang, Xiao-Chun Hou, Hai-Long Yang, Qin-Hua Lin, Yun-Xin Zhu, Lei Zhao(co-corresponding author), Wen-Liang Zhou, Yi-Lin Zhang.Allicin facilitates airway surface liquid hydration by activation of CFTR. Front Pharmacol, 2022 Jun 15;13:890284.doi: 10.3389/fphar.2022.890284. eCollection 2022.(IF=5.988)

4. Zhoulin Chang, Zhiqing Zhan , Zifan Zhao, Zhixuan You, Yang Liu, Zhihong Yan, Yong Fu, Wenhua Liang, Lei Zhao(corresponding author). Application of artificial intelligence in COVID-19 medical area: a systematic review. J Thorac Dis. 2021 Dec;13(12):7034-7053.doi: 10.21037/jtd-21-747. (IF=2.895)

5. Lei Zhao(firstauthor), Yu-Ting Liang , Dong-Bo Tian , Rui-Gang Zhang , Jiehong Huang , Yun-Xin Zhu , Wen-Liang Zhou, Yi-Lin Zhang . Regulation of smooth muscle contractility by the epithelium in rat tracheas: role of prostaglandin E 2induced by the neurotransmitter acetylcholine. Ann Transl Med, 2021,9(4):313. (IF=3.932)

6. Yilin Yang, Peilin Pang, Zihong Xie1, Nian Wang, Hengrui Liang, Lei Zhao(corresponding author). The safety of first and subsequent lines of PD-1/PD-L1 inhibitors monotherapy in non-small cell lung cancer patients: a meta- analysis. Transl Cancer Res 2020;9(5):3231-3241 (IF=1.241)

7. Chen QZ, Zhou YB, Zhou LF, Fu ZD,Yang CT, Zhao L, Li SN, Chen Y, Wu YS, Ling ZW, Wang YF, Huang JR, Li JH. TRPC6-dependent Ca2+ signaling mediates airway inflammation in response to oxidative stress via ERK pathway. Cell Death & Disease,2020, 11(3): 170. (IF=5.959)

8. Liang H, Liang W, Zhao L, Chen D, Zhang J, Zhang Y, Tang S, He J. Robotic Versus Video-assisted Lobectomy/Segmentectomy for Lung Cancer: A Meta-analysis. Ann Surg. 2018; 268: 254-9. (IF= 8.569)

9. Zhang YL, Chen PX, Guan WJ, Guo HM, Qiu ZE, Xu JW, Luo YL, Lan CF, Xu JB, Hao Y, Tan YX, Ye KN, Lun ZR, Zhao L, Zhu YX, Huang J, Ko WH, Zhong WD, Zhou WL*, Zhong NS*. Increased intracellular Cl- concentration promotes ongoing inflammation in airway epithelium. Mucosal Immunol. 2018; 11(4): 1149-1157. （IF=7.352）

10. Chen PX, Zhang YL, Xu JW, Yu MH, Huang JH, Zhao L*(co-corresponding author), Zhou WL. Sodium tanshinone IIA sulfonate stimulated Cl- secretion in mouse trachea. PLoS One. 2017; 12: e0178226. （IF=2.776）

11. Zhang YL, Xu JW, Wu XH, Chen PX, Wei F, Gao DD, Chen XW, Luo YL, Zhu YX, Huang J, Tan YX, Zhao L*(co-corresponding author), Zhou WL. Relaxant Effect of Sodium Tanshinone IIA Sulphonate on Mouse Tracheal Smooth Muscle. Planta Med. 2017; 83: 624-30. （IF=2.746）

12. Wang J, Chen Y, Lin C, Jia J, Tian L, Yang K, Zhao L, Lai N, Jiang Q, Sun Y, Zhong N, Ran P, Lu W. Effects of chronic exposure to cigarette smoke on canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol. 2014; 306: C364-73. (IF= 3.454)

13. Zhao L (first author), Wang J#, Wang L#, Liang YT, Chen YQ, Lu WJ, Zhou WL. Remodeling of rat pulmonary artery induced by chronic smoking exposure. J Thorac Dis. 2014; 6: 818-28. (IF= 2.027)

14. Wang J, Jiang Q, Wan L, Yang K, Zhang Y, Chen Y, Wang E, Lai N, Zhao L, Jiang H, Sun Y, Zhong N, Ran P, et al. Sodium tanshinone IIA sulfonate inhibits canonical transient receptor potential expression in pulmonary arterial smooth muscle from pulmonary hypertensive rats. Am J Respir Cell Mol Biol. 2013; 48: 125-34. doi: 10.1165/rcmb.2012-0071OC. (IF= 3.454)

15. Yu KY, Zhao L (co-first author), Chen Z, Yang M. Noninvasive positive pressure ventilation for the treatment of acute respiratory distress syndrome following esophagectomy for esophageal cancer: a clinical comparative study. J Thorac Dis. 2013; 5: 777-82. (IF= 2.027)

  16. Zhao L (first author), Wang Z#, Ruan YC, Zhou WL. Cellular mechanism underlying the facilitation of contractile response of vas deferens smooth muscle by sodium orthovanadate. Mol Cell Biochem. 2012; 366: 149-57. (IF= 2.057)