个人概况
黄洪标,男,研究员 导师资格:博士生导师,广州医科大学基础医学院,博士研究生,毕业院校:广州医科大学,招生专业: 病理学与病理生理学
电子邮件: hhb800616@126.com
研究方向
蛋白质修饰与肿瘤
所获荣誉
1. 广东省高校优秀青年教师培养对象
2. 蛋白酶体功能调节在肿瘤中的作用及其意义, 教育部高校优秀成果自然科学二等奖, 2021, 排名第二
3. 蛋白酶体功能调节及其意义, 中华医学会科技进步三等奖,2017,排名第二
4. 蛋白酶体功能调节及其意义,广州市科技进步一等奖,2016,排名第二
指导学生获得的科研项目和奖项
1. 广东省优秀研究生2. 国家奖学金
社会兼职
1. 中国病理生理学会蛋白质修饰与疾病专委会青年工作委员会委员2. 广东省病理生理学会肿瘤专业委员会委员
主持科研项目
1. 广州医科大学国家杰青培育项目, 蛋白质修饰、降解与肿瘤,2022-01至2023-12,60万元,在研,主持;
2. 国家自然科学基金委员会,面上项目,82072810,GRP75招募去泛素化酶USP1调控SIX1降解促进前列腺癌生长,2021-01至2024-12,56万元,在研,主持;
3. 广州市科学技术局,雌激素受体泛素化降解调控在乳腺癌中的作用及机制,广州市科技计划项目,202002030107,2020-04 至 2022-03,20万元,在研,主持
4. 国家自然科学基金委员会,面上项目,81872151,去泛素化酶USP7调控ER阳性乳腺癌生长的分子机制研究,2019-01至2022-12,57万元,在研,主持;
5. 国家自然科学基金委员会,面上项目,81670156,去泛素化酶USP10调控慢性粒细胞白血病细胞生长的分子机制研究,2017-01至2020-12,60万元,已结题,主持;
6. 国家自然科学基金委员会,面上项目,81472390,去泛素化酶USP14调控前列腺癌生长的分子机制研究,2015-01至2018-12,70万元,已结题,主持;
7. 国家自然科学基金委员会,青年项目,81201719,金诺芬抑制蛋白质降解在抗肿瘤治疗中的作用,2013-01至2015-12,23万元,已结题,主持
近5年代表性通讯作者论文:
1. Liao Y#, Liu Y#, Shao Z#, Xia X, Deng Y, Cai J, Yao L, He J, Yu C, Hu T, Sun W, Liu F, Tang D, Liu J*, Huang H*, A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance, Oncogene, 2021, 40(25):4291-4306. (IF=9.867)
2. Liao Y#, Shao Z#, Liu Y#, Xia X, Deng Y, Yu C, Sun W, Kong W, He X, Liu F, Guo Z, Chen G, Tang D, Gan H*, Liu J*, Huang H*, USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells, Journal of Experimental & Clinical Cancer Research, 2021, 40(1):201. (IF=11.161)
3. Liao Y#, Yu C#, Shao Z, Xia X, Hu T, Kong W, He X, Sun W, Deng Y, Liao Y*, Huang H*, Selective degradation of AR-V7 to overcome castration resistance of prostate cancer, Cell Death & Disease, 2021, 12(10):857. (IF=8.469)
4. Xia X#, Huang C#, Liao Y#, Liu Y, He J, Shao Z, Hu T, Yu C, Jiang L, Liu J*, Huang H*, The deubiquitinating enzyme USP15 stabilizes ERα and promotes breast cancer progression, Cell Death & Disease, 2021, 12(4):329. (IF=8.469)
5. Liao Y#, Liu Y#, Xia X#, Shao Z, Huang C, He J, Jiang L, Tang D, Liu J*, Huang H*. Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy . Theranostics, 2020; 10(8): 3366-3381. (IF=11.556)
6.Xia X#, Liao Y#, Huang C#, Liu Y, He J, Shao Z, Jiang L, Dou QP, Liu J*, Huang H*.Deubiquitination and stabilization of estrogen receptor α by ubiquitin-specific protease 7 promotes breast tumorigenesis.Cancer Letters, 2019 Nov 28;465:118-128. (IF=8.679)
7. Xia X#, Huang C#, Liao Y#, Liu Y, He J, Guo Z, Jiang L, Wang X, Liu J*, Huang H*. Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide. Journal of Experimental & Clinical Cancer Research, 2019 ;38(1):220. (IF= 11.161)
8. Liao Y#, Guo Z#, Xia X#, Liu Y, Huang C, Jiang L, Wang X, Liu J*, Huang H*. Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer. Journal of Experimental & Clinical Cancer Research, 2019 Apr 11;38(1):157. (IF= 11.161)
9. Liao Y#, Liu N#, Xia X, Guo Z, Li Y, Jiang L, Zhou R, Tang D, Huang H*, Liu J*. USP10 Modulates the SKP2/Bcr-Abl axis via Stabilizing SKP2 in Chronic Myeloid Leukemia. Cell Discovery, 2019 Apr 30;5:24. (IF= 10.849)
10. Liao Y#, Xia X#, Liu N#, Cai J, Guo Z, Li Y, Jiang L, Dou Q, Tang D, Huang H*, Liu J*. Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination. Oncogene, 2018 Apr;37(14):1896-1910. (IF= 9.867)
11. Xia X#, Liao Y#, Guo Z, Li Y, Jiang L, Zhang F, Huang C, Liu Y, Wang X, Liu N, Liu J*, Huang H*. Targeting proteasome associated deubiquitinases as a novel strategy for the treatment of estrogen receptor positive breast cancer. Oncogenesis, 2018 Sep 24;7(9):75. (IF=7.485)