个人概况
姓 名：侯智尧 性 别：男
职 称：教 授 学 历：博 士
毕业院校：哈尔滨工程大学 导师资格：博士生、硕士生导师 单 位：基础医学院 招生专业： 病理学与病理生理学、生物医学工程
电子邮件： zyhou@gzhmu.edu.cn 通信地址： 广州医科大学番禺校区A1-639室
研究方向
针对光能转换材料合成与应用中的基本科学问题，以电子跃迁和稀土离子能量传递为理论基础，结合医学、生物学、材料学和化学等多学科交叉的研究优势，开展新型纳米光能转换材料构建及其在疾病光学诊疗中应用的基础研究，目前在Adv. Mater.、Angew. Chem. Int. Ed.、Adv. Funct. Mater.、ACS Nano、Adv. Sci.、Biomaterials等国际学术期刊上发表SCI论文143篇，论文被他人引用超过14000次，H-index指数为68，ESI高被引论文8篇，入选斯坦福大学-爱思唯尔数据库发布的《全球前2%顶尖科学家榜单》的“终身科学影响力榜单”。
(1) 多模态影像导航下的近红外光响应抗肿瘤协同治疗；
(2) 肿瘤微环境响应的温度可控光热治疗；
(3) 肿瘤的离子干扰疗法；
(4) 蛋白及核酸的时间分辨检测；
(5) 牙周相关疾病/神经退行性疾病的光学治疗。
社会兼职
1. 中国稀土学会稀土晶体专业委员会委员
2. 中国稀土学会发光专业委员会委员
3. 广东省材料研究学会无机材料专业委员会委员
4. 《广州医科大学学报》编委
5. 《发光学报》青年编委
主持科研项目
(1) 国家自然科学基金面上项目，编号：52372078，项目名称：多孔复合结构的单原子纳米酶用于热休克蛋白沉默诱导的温和光热治疗，起止时间：2024/01-2027/12，资助金额：直接经费50 万元，在研，主持；
(2) 国家自然科学基金面上项目，编号：52072082，项目名称：可分解的碳酸钙包覆氧化亚铜纳米复合材料用于结直肠肿瘤微环境触发的多模态协同治疗，起止时间：2021/01-2024/12，资助金额：58 万元，在研，主持；
(3) 国家自然科学基金面上项目，编号：51672268，项目名称：多功能羟基磷灰石纳米晶的控制合成及其在活性组织工程骨构建中的应用，起止时间：2017/01-2020/12，资助金额：62 万元，已结题，主持；
(4) 国家自然科学基金面上项目，编号：51472233，项目名称：二氧化钛/稀土上转换发光纳米复合材料的合成及其近红外光响应光动力疗法抗肿瘤作用的研究，起止时间：2015/01-2018/12，资助金额：83 万元，已结题，主持；
(5) 国家自然科学基金青年项目，编号：51202239，项目名称：多功能介孔SiO2/水凝胶纳米复合纤维双重载药体系的制备，起止时间：2013/01-2015/12，资助金额：25 万元，已结题，主持；
(6) 国家自然科学基金海外及港澳学者合作基金，编号：51828202，项目名称：染料敏化上转换纳米材料的调控及在肿瘤诊疗中的应用，起止时间：2019/01-2020/12，资助金额：18 万元 (直接经费)，已结题，国内主持；
(7) 广东省普通高校重点领域专项，编号：2020ZDZX2020，项目名称：肿瘤微环境响应的智能光热治疗剂制备及其近红外光诱导的肿瘤光热治疗研究，起止时间：2021/01-2024/12，资助金额：15 万元，在研，主持；
指导团队成员获得科研项目：
(1) 国家自然科学基金青年项目，编号：52402105，项目名称：CuO/FeOCl纳米异质结的构建及其超声催化析氧诱导高效铜死亡的研究，起止时间：2025/01-2027/12，资助金额：30 万元，在研，主持；(陈炜，博士后)
(2) 国家自然科学基金青年项目，编号：52302086，项目名称：具有酶活性和免疫激活功能的纳米复合材料的原位构筑及其肿瘤放疗增敏的研究，起止时间：2024/01-2026/12，资助金额：30 万元，在研，主持；(谭美玲，博士后)
(3) 国家自然科学基金青年项目，编号：32101143，项目名称：光学治疗激活的促吞噬纳米颗粒用于巨噬细胞介导抗肿瘤免疫治疗的研究，起止时间：2022/01-2024/12，资助金额：30 万元，结题，主持；(张亚茹，助理研究员)
(4) 中国博士后基金面上项目，编号：2025M782905，项目名称：光热敏化MnOx@CaCO3纳米复合材料双重策略激活cGAS-STING通路用于增强抗肿瘤免疫治疗的研究，起止时间：2026/01-2027/12，资助金额：8万，在研，主持；(高智敏，博士后)
部分代表性第一和通讯作者论文：
1.Meiling Tan, Zhimin Gao, Xinyi Wang, Xiaozhao Wang, Chen Lin, Yongxin Huang, Wei Chen, Yaru Zhang, Zhiyao Hou*, MnO2@CeOx-GAMP radiosensitizer with oxygen vacancies depended mimicking enzyme-like activities for radiosensitization-mediated STING pathway activation, Biomaterials, 2025, 314, 122797. (IF:12.9)
2.Yaru Zhang, Wenyu Xie, Jiamin Luo, Rui Gao, Zhimin Gao, Xinyi Wang, Yongxin Huang, Chen Lin, Meiling Tan, Zhiyao Hou*, NIR-activated endoplasmic reticulum stress amplifier to regulate phagocytosis for macrophage-mediated cancer immunotherapy, Chemical Engineering Journal, 2025, 509,161351. (IF:13.2)
3.Wei Chen, Chen Lin, Zhimin Gao, Yongxin Huang, Xinyi Wang, Qian Zhang, Yaru Zhang, Meiling Tan, Zhiyhao Hou, Zhiyao Hou*, A tumor microenvironment-responsive nanocomposite for enhanced copper retention and hypoxia reversal to promote cuproptosis in tumor treatment, Acta Biomaterialia, 2025, 202, 463-475. (IF:9.6)
4. Tianchen Li, Mengmeng Shu, Cheng Zhu, Qicheng Liu, Yixin Li, Ruike Wang, Lihan Chen, Wenxiao Shi, Zhaoxuan Sun, Zhiyao Hou*, Bing Fang*, Lunguo Xia*, Triple-Combination Therapy with a Multifunctional Yolk-Shell Nanozyme Au@CeO2 Loaded with Dimethyl Fumarate for Periodontitis, Advanced Science, 2025, 12(7), 2413891. (IF:14.1)
5. Xiaozhao Wang, Jing Li, Zhengtao Luo, Zhimin Gao, Yongxin Huang, Jiamin Luo, Xinyi Wang, Yaru Zhang*, Meiling Tan*, Zhiyao Hou*,ATP-Exhausted Strategy Induced Anti-Tumor Low-Temperature Photothermal Therapy Based on Rare Earth Nanocrystals Modified Hollow Porous MnOx Nanozyme with TME-Activated NIR-II Imaging, Small, 2025, 21(14), 2410070. (IF:12.1)
6. Weifeng Tian, Qi Jia, Jiewen Lin, Jiamin Luo, Dongmei He, Jie Yang, Tao Guo, Huiling Guo, Yusheng Guo, Wenjie Zhang, Feiyu Chen, Ying Ye, Jingjing Liu, Mindong Xu, Chengjie Deng, Boxiang Cui, Deyuan Su, Hao Wang, Yi Lu, Jianru Xiao, Heng Liu, Jian Yang, Zhiyao Hou*, Shu Wang*, Remote neurostimulation through an endogenous ion channel using a near-infrared light-activatable nanoagonist, Science Advances, 2024, 10(32), eadn0367. (IF:12.5)
7. Meiling Tan, Zhimin Gao, Xiaozhao Wang, Chen Lin, YuChi Wang, Wenyu Xie, Wei Chen, Yaru Zhang, Zewei Quan*, Zhiyao Hou*, MnO2 nanozyme with lanthanide-based radiosensitization for advanced radiotherapy by tumor microenvironment triggering STING pathway activation, Chemical Engineering Journal, 2024, 486, 150364. (IF:13.2)
8. Wei Chen, Wenyu Xie, Zhimin Gao, Chen Lin, Meiling Tan, Yaru Zhang, Zhiyao Hou*, Mild-Photothermal Effect Induced High Efficiency Ferroptosis-Boosted-Cuproptosis Based on Cu2O@Mn3Cu3O8 Nanozyme, Advanced Science, 2023, 10 (33), 2303694. (IF:14.1, ESI高被引论文)
9. Yaru Zhang, Zhaoru Zhou, Zhimin Gao, Xinan Li, Xiaozhao Wang, Zhaocong Zheng, Jing Deng, Donglian Liu, Tieli Peng*, Zhiyao Hou*, Mild photothermal treatment sensitized immune checkpoint blockade therapy based on ATP-exhausted nanoenzymes, Chemical Engineering Journal, 2023, 474, 145677. (IF:13.2)
10. Man Wang, Mengyu Chang, Chunxia Li*, Qing Chen, Zhiyao Hou*, Bengang Xing, Jun Lin*, Tumor-Microenvironment-Activated Reactive Oxygen Species Amplifier for Enzymatic Cascade Cancer Starvation/Chemodynamic/Immunotherapy, Advanced Materials, 2022, 34(4), 2106010. (IF:26.8, ESI高被引论文)
11. Mengyu Chang, Zhiyao Hou*, Man Wang, Ding Wen, Chunxia Li, Yuhui Liu, Yali Zhao*, Jun Lin*, Cu Single Atom Nanozyme Based High-Efficiency Mild Photothermal Therapy through Cellular Metabolic Regulation, Angewandte Chemie International Edition, 2022, 61(50), e202209245. (IF:17)
12. Zhaoru Zhou, Zhimin Gao, Wei Chen, Xiaozhao Wang, Zhankun Chen, Zaocong Zheng, Qianyi Chen, Meiling Tan, Donglian Liu*, Yaru Zhang*, Zhiyao Hou*, Nitric oxide-mediated regulation of mitochondrial protective autophagy for enhanced chemodynamic therapy based on mesoporous Mo-doped Cu9S5 nanozymes, Acta Biomaterialia, 2022, 151, 600-612. (IF:9.6)
13. Mengyu Chang, Zhiyao Hou*, Man Wang, Chunxia Li, Jun Lin*, Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy, Advanced Materials, 2021, 33(4), 2004788. (IF:26.8, ESI高被引论文)
14. Mengyu Chang, Zhiyao Hou*, Man Wang, Chunzheng Yang, Ruifeng Wang, Fang Li, Donglian Liu, Tieli Peng, Chunxia Li*, Jun Lin*, Single Atom Pd Nanozyme for Ferroptosis-Boosted Mild-Temperature Photothermal Therapy, Angewandte Chemie International Edition, 2021, 60(23), 12971–12979. (IF:17, ESI高被引论文)
15. Meifang Wang, Zhiyao Hou*, Saina Liu, Shuang Liang, Binbin Ding, Yajie Zhao, Mengyu Chang, Gang Han, Abdulaziz A. Al Kheraif, Jun Lin*, A Multifunctional Nanovaccine based on L-Arginine-Loaded Black Mesoporous Titania: Ultrasound-Triggered Synergistic Cancer Sonodynamic Therapy/Gas Therapy/Immunotherapy with Remarkably Enhanced Efficacy, Small, 2021, 17(6), 2005728. (IF:12.1)
16. Mengyu Chang, Zhiyao Hou*, Dayong Jin*, Jiajia Zhou, Man Wang, Meifang Wang, Mengmeng Shu, Binbin Ding, Chunxia Li, Jun Lin*, Colorectal Tumor Microenvironment‐Activated Bio‐Decomposable and Metabolizable Cu2O@CaCO3 Nanocomposites for Synergistic Oncotherapy, Advanced Materials, 2020, 32(43), 2004647. (IF:26.8)
17. Mengyu Chang, Zhiyao Hou*, Man Wang, Meifang Wang, Peipei Dang, Jianhua Liu, Mengmeng Shu, Binbin Ding, Abdulaziz A. Al Kheraif, Chunxia Li*, Jun Lin*, Cu2MoS4/Au Heterostructures with Enhanced Catalase-Like Activity and Photoconversion Efficiency for Primary/Metastatic Tumors Eradication by Phototherapy-Induced Immunotherapy, Small, 2020, 16(14), 1907146. (IF:12.1)
18. Man Wang, Mengyu Chang, Qing Chen, Dongmei Wang, Chunxia Li*, Zhiyao Hou*, Jin Lin*, Dayong Jin, Bengang Xing, Au2Pt-PEG-Ce6 Nanoformulation with Dual Nanozyme Activities for Synergistic Chemodynamic Therapy/Phototherapy, Biomaterials, 2020, 252, 120093. (IF:12.9, ESI高被引论文)
19. Mengyu Chang, Man Wang, Meifang Wang, Mengmeng Shu, Binbin Ding, Chunxia Li, Maolin Pang, Shuzhong Cui, Zhiyao Hou*, Jun Lin*, A Multifunctional Cascade Bioreactor Based on Hollow Structured Cu2MoS4 for Synergetic Cancer Chemo-Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy, Advanced Materials, 2019, 31(51), 1905271. (IF:26.8, ESI高被引论文)
20. MeiFang Wang, Kerong Deng, Wei Lü, Xiaoran Deng, Kai Li, Yanshu Shi, Binbin Ding, Ziyong Cheng, Zhiyao Hou*, Jun Lin*, Rational Design of Multifunctional Fe@γ-Fe2O3@H-TiO2 Nanocomposites with Enhanced Magnetic and Photoconversion Effects for Wide Applications: from Photocatalysis to Imaging-guided Photothermal Cancer Therapy, Advanced Materials, 2018, 30(13), 1706747. (IF:26.8)
21. Bei Liu, Chunxia Li*, Piaoping Yang, Zhiyao Hou*, Jun Lin*, 808-nm-Light-Excited Lanthanide-Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications, Advanced Materials, 2017, 29(18), 1605434. (IF:26.8)
22. Kerong Deng, Chunxia Li, Shanshan Huang, Bengang Xing, Dayong Jin, Qingguang Zeng, Zhiyao Hou*, Jin Lin*, Recent Progress in Near Infrared Light Triggered Photodynamic Therapy, Small, 2017, 13(44), 1702299. (IF:12.1)
23. Zhiyao Hou, Kerong Deng, Chunxia Li, Xiaoran Deng, Hongzhou Lian, Ziyong Cheng, Dayong Jin, Jun Lin*, 808 nm Light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing Nd3+-sensitized upconversion emission with enhanced anti-tumor efficacy, Biomaterials, 2016, 101, 32–46. (IF:12.9)
24. Kerong Deng, Zhiyao Hou*, Xiaoran Deng, Piaoping Yang, Chunxia Li, Jun Lin*, Enhanced Antitumor Efficacy by 808 nm Laser-Induced Synergistic Photothermal and Photodynamic Therapy Based on a Indocyanine-Green-Attached W18O49 Nanostructure, Advanced Functional Materials, 2015, 25(47), 7280–7290. (IF:19)
25. Zhiyao Hou, Yuanxin Zhang, Kerong Deng, Yinyin Chen, Xuejiao Li, Xiaoran Deng, Ziyong Cheng, Hongzhou Lian, Chunxia Li*, Jun Lin*, UV-Emitting Upconversion-Based TiO2 Photosensitizing Nanoplatform Near-Infrared Light Mediated in Vivo Photodynamic Therapy via Mitochondria-Involved Apoptosis Pathway, ACS Nano, 2015, 9(3), 2584–2599. (IF:16.1, ESI高被引论文)
