个人概况

个人简介

        付晓东，男，1976年生，教授，博士生导师，现任广州医科大学副校长。长期从事生殖激素与女性心肺血管疾病的研究。兼任呼吸疾病全国重点实验室血管组学副组长，广东省教育厅高校血管重点实验室副主任，广东省生理学会副理事长、中国病理生理学会缺氧与呼吸专业委员会副主任委员。主持国家自然科学基金6项、广东省教育厅血管创新团队项目、广东省自然科学基金等课题10余项。自07年以来以第一或通讯作者发表论文49篇，其中SCI收录论文46篇。

研究方向

生殖激素与心肺血管疾病

所获荣誉

1. 2025年获得“广东省卫健委特支计划领军人才项目”

学会任职

指导学生获得的科研项目和奖项

1. 2017年培养博士研究生李潇洒获得“国家奖学金”；

2. 2017年培养博士研究生李潇洒获得“优秀研究生”称号；

3. 2018年培养博士研究生李潇洒获得“广州医科大学第二届研究生学术科普大赛”二等奖；

4. 2019年培养博士研究生李潇洒获得“广州市医学会优秀论文”二等奖；

5. 2019年培养博士研究生孟璇获得“广东省生理学会青年优秀论文”二等奖；

6. 2019年培养硕士研究生徐星燕获得“广东省生理学会青年优秀论文”二等奖；

7. 2023年培养硕士研究生高泳琦获得“国家奖学金”；

8. 2023年培养博士研究生郭瑞新获得“广州医科大学第一届博士学术论坛”三等奖；

9. 2023年培养硕士研究生高泳琦获得“中国酒城国际心血管医学学术会议壁报展示”三等奖；

10. 2023年培养博士研究生王家乐获得“中国酒城国际心血管医学学术会议青年学者报告”三等奖；

11. 2023年培养博士研究生郭瑞新获得“中国酒城国际心血管医学学术会议壁报展示”二等奖；

主持科研项目

1、主持国家级自然科学基金面上项目（NO: 82471679）雌激素降低RNF181表达促进GTSE1泛素化修饰、延缓低氧性肺动脉高压发生的机制探究。资助经费：46万，起止年月：2025.1-2028.12，在研。

2、主持国家级自然科学基金面上项目（NO: 82171631）常氧/低氧状态下雌激素逆向调控肺动脉血管平滑肌细胞METTL3/PFKFB3表达及肺动脉高压发生的作用机制研究。资助经费：54万，起止年月：2022.1-2025.12，在研。

代表性第一和通讯作者论文：

1） Lu L, Chen Y, Liu B, Li X, Wang J, Nie Z, Fu X*. Association between cumulative changes of the triglyceride glucose index and incidence of stroke in a population with cardiovascular-kidney-metabolic syndrome stage 0-3: a nationwide prospective cohort study. Cardiovascular Diabetology. 2025 May 12;24(1):202. IF 10.6

2） M. Kong, Z. Wu, Z. Zheng, B. Zhang, Y. Zeng, H. Deng, D. Feng, W. Zhang, C. Li, X. Fu*, L. Wang*, Construction strategies for 3D printed cardiac tissue repair materials and their application potential. Interdisciplinary Medicine. 2025, e20240085. IF 12.8

3） Li P, Xiang Y, Wei J, Xu X, Wang J, Yu H, Li X*, Lin H*, Fu X*. Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression. Cellular & molecular biology letters. 2025; 30: 41. IF 9.2

4） Wang Y, He S, Lan L, Yu H, Zhao H, Xie Y, Zhong G, Yuan L, Li K, Hu X, Macrae VE, Fu X*, Chen G*, Zhu D*. The N6-methyladenosine demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification. Cardiovascular Research. 2025 Apr 15;121(1):190-204. IF 13.3

5） Li X, Wang J, Chen Y, Li P, Wen H, Xu X, Wang J, Xu Y, Chen Y, Song J, Lu W*, Zhu D*, Fu X*. Estrogen Oppositely Regulates Pulmonary Hypertension via METTL3/PFKFB3 Under Normoxia and Hypoxia. American journal of respiratory cell and molecular biology. Published online September 12, 2024. doi:10.1165/rcmb.2024-0042OC. IF 5.9

6） Li P, Chen Y, Xiang Y, Guo R, Li X, Liu J*, Zhou Y*, Fu X*. 17β-estradiol promotes myeloid-derived suppressor cells functions and alleviates inflammatory bowel disease by activation of Stat3 and NF-κB signalings. The Journal of steroid biochemistry and molecular biology. 2024;242:106540. IF 2.7

7） Jia H, Chang Y, Chen Y, Chen X, Zhang H, Hua X, Xu M, Sheng Y, Zhang N, Cui H, Han L, Zhang J*, Fu X*, Song J*. A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging. Communications biology. 2024 Apr 8;7(1):427. IF 5.2

8） Xu X, Zhuang X, Yu H, Li P, Li X, Lin H, Teoh JP, Chen Y, Yang Y, Cheng Y*, Chen W*, Fu X*. FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation. Theranostics. 2024; 14(5): 2151-2166. IF 12.4

9） Li X, Fan C, Wang J, Li P, Xu X, Guo R, Wei J, Cheng Y*, Lin H*, Fu X*. Follicle-stimulating hormone accelerates osteoclast migration by enhancing methyltransferase-like 3-mediated m6a methylation of cathepsin k. Journal of molecular endocrinology. 2024; 72(3):e230130. IF 3.5

10） Cao K, Zhang T, Li Z, Song M, Li A, Yan J, Guo S, Wang L, Huang S, Li Z, Hou W, Dai X, Wang Y, Feng D, He J, Fu X*, Xu Y*. Glycolysis and de novo fatty acid synthesis cooperatively regulate pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia. The Journal of pathology. 2023; 259(4):388-401. IF 7.3

11） Wang S, Yu H, Gao J, Chen J, He P, Zhong H, Tan X, Staines KA, Macrae VE, Fu X*, Jiang L*, Zhu D*. Palmd regulates aortic valve calcification via altered glycolysis and nf-κb-mediated inflammation. Journal of biological chemistry. 2022; 298(5):101887. IF 4.8

12） Guo S#, Li A#, Fu X#, Li Z, Cao K, Song M, Huang S, Li Z, Yan J, Wang L, Dai X, Feng D, Wang Y, He J, Huo Y, Xu Y. Gene-dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis. British journal of pharmacology. 2022; 179(21):4974-4991. IF 7.3

13） Chen J, Yu H, Tan X, Mok SWF, Xie Y, Wang Y, Jiang X, Macrae VE, Lan L*, Fu X*, Zhu D*. Pfkbf3-driven vascular smooth muscle cell glycolysis promotes vascular calcification via the altered foxo3 and lactate production. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 2023; 37(10): e23182. IF 4.8

14） Zheng S, Wu L, Fan C, Lin J, Zhang Y, Simoncini T, Fu X*. The role of gα protein signaling in the membrane estrogen receptor-mediated signaling. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology. 2021; 37(1):2-9. IF 2.0

15） Zhao X, Li X, Liu P, Li P, Xu X, Chen Y, Cheng Y*, Zhu D* and Fu X*. 17β-estradiol promotes angiogenesis through non-genomic activation of smad1 signaling in endometriosis. Vascular pharmacology. 2021;142:106932. IF 4.0

16） Teoh J P, Li X, Simoncini T, Zhu D*, and Fu X* (2020). Estrogen-mediated gaseous signaling molecules in cardiovascular disease. Trends in endocrinology and metabolism.2020;31(10):773-784. IF 10.9

17） He P, Yu H, Jiang L, Chen Z, Wang S, Macrae VE, Fu X*, and Zhu D*. Hdac9 inhibits medial artery calcification through down-regulation of osterix. Vascular pharmacology. 2020;132:106775. IF 4.0

18） Zhao L, Cao X, Li L, Wang X, Wang Q, Jiang S, Tang C, Zhou S, Xu N, Cui Y, Hu W, Fei L, Zheng Z, Chen L, Schmidt MO, Wei Q, Zhao J, Labes R, Patzak A, Wilcox CS, Fu X*, Wellstein A*, and Lai EY*. Acute kidney injury sensitizes the brain vasculature to ang II (angiotensin II) constriction via fgfbp1 (fibroblast growth factor binding protein 1). Hypertension. 2020;76(6):1924-1934. IF 8.3

19） Chen Z, F. Gordillo-Martinez, Jiang L, He P, Hong W, Wei X, Staines KA., Macrae VE., Zhang C, Yu D, Fu X*, Zhu D*. Zinc ameliorates human aortic valve calcification through gpr39 mediated erk1/2 signaling pathway. Cardiovascular research. 2021;117(3):820-835. IF 10.9

20） Xu X., Yan Q, Liu X, Li P, Li X, Chen Y, Simoncini T, Liu J, Zhu D*, Fu X*. 17beta-Estradiol nongenomically induces vascular endothelial H₂S release by promoting phosphorylation of cystathionine gamma-lyase. Journal of biological chemistry, 2019; 294(43):15577-15592. IF 4.8

21） Meng X, Li X, Xu X, Li P, Chen Y, Fu X*, Xu X*. Elevated luteinizing hormone contributes to atherosclerosis formation by inhibiting nitric oxide synthesis via pi3k/akt pathway. Vascular pharmacology. 121: 106582. IF 4.0