【个人简介】

廖矿标，男，研究员，博士研究生学历，国家海外高层次青年人才，广东青年五四奖章获得者。2013年本科毕业于中山大学，2017年博士毕业于美国埃默里大学。2018年加入艾伯维医药公司，2019年担任生物岛实验室研究员、化学合成平台主任，2021年调入广州实验室任研究员，2022年双聘至广州医科大学。至今，已以通讯作者或第一作者在Nature（2篇）、Nat. Chem、Chem、ACS Catal.、Angew. Chem. Int. Ed.等期刊上发表多篇论文，并多次被Nature等期刊杂志重点报道。主持国家自然科学基金重大项目、国家自然科学基金面上项目和国家重大人才项目（青年）等。

【联系邮箱】liao_kuangbiao@gzlab.ac.cn

【研究方向类别】

1、学术学位：药物化学

2、专业学位：工业药学（转化药学）

【具体研究方向】

自动化与人工智能辅助的化学合成方法学开发、新药研发

【主要科研项目】

主持纵向项目3项：

1.国家自然科学基金重大项目

2.国家自然科学基金面上项目

3.国家重大人才项目（青年）

【所获荣誉和奖励】

曾获广州市最美科技工作者、黄埔区最美科技工作者、广东青年五四奖章、国家海外高层次青年人才、广州市优秀专家、黄埔区优秀人才、黄埔区精英人才、Reaxys PhD Prize Finalist、Osborne R. Quayle Student Achievement Award、《科学中国人》杂志社“年度科技新锐”和福布斯中国·青年海归菁英100人等荣誉。

【主要论文及著作（代表性）】

代表性成果

1.Kuangbiao Liao, Solymar Negretti, Djamaladdin G. Musaev, John Bacsa & Huw M. L. Davies. 2016. Site-selective and stereoselective functionalization of unactivated C–H bonds. Nature. 533 (230–234). 

2.Kuangbiao Liao, Thomas C. Pickel, Vyacheslav Boyarskikh, John Bacsa, Djamaladdin G. Musaev & Huw M. L. Davies. 2017. Site-selective anstereoselective functionalization of non-activated tertiary C–H bonds. Nature. 551 (609–613).

3.Kuangbiao Liao,Yun-Fang Yang,Yingzi Li,Jacob N. Sanders,K. N. Houk,Djamaladdin G. Musaev &Huw M. L. Davies. 2018. Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C–H bonds. Nature Chemistry. 10(1048–1055).

4.Huw M. L. Davies & Kuangbiao Liao. 2019. Dirhodium tetracarboxylates as catalysts for selective intermolecular C–H functionalization. Nature Reviews Chemistry. 3 (347–360).

5.Jia Qiu#, Jiancong Xie#, Shimin Su, Yadong Gao, Han Meng, Yuedong Yang* & Kuangbiao Liao*. 2022. Selective Functionalization of Hindered meta-C–H bond of o-Alkylaryl Ketones Promoted by Automation and Deep Learning. Chem. 8 (3275-3287).

6.Jia Qiu, Yougen Xu, Shimin Su, Yadong Gao, Peiyuan Yu, Zhixiong Ruan* & Kuangbiao Liao*. 2023. Auto Machine Learning Assisted Preparation of Carboxylic Acid by TEMPO-Catalyzed Primary Alcohol Oxidation. Chin. J. Chem. 41 (143-150).

7.Yougen Xu, Feixiao Ren, Lebin Su*, Zhaoping Xiong, Xinwei Zhu, Xinyuan Lin, Nan Qiao, Hao Tian, Changen Tian & Kuangbiao Liao*.  2023. HTE and machine learning-assisted development of iridium (I)-catalyzed selective O–H bond insertion reactions toward carboxymethyl ketones. Org. Chem. Front. 10 (1153-1159).

8.Zhunzhun Yu, Yaxian Kong, Baiqing Li, Shimin Su, Jianhang Rao, Yadong Gao, Tianyong Tu, Hongming Chen* & Kuangbiao Liao*. 2023. HTE and AI-Assisted Development of DHP Catalyzed Decarboxylative Selenation. Chem. Comm. 59 (2935-2938).

9.Yougen Xu, Yadong Gao, Lebin Su*, Haiting Wu, Hao Tian, Majian Zeng, Chunqiu Xu, Xinwei Zhu & Kuangbiao Liao*. 2023. High-Throughput Experimentation and Machine Learning-Assisted Optimization of Iridium-Catalyzed Cross-Dimerization of Sulfoxonium Ylides. Angew. Chem. Int. Ed. 62, e202313638. 

10. Yadong Gao, Kunjun Hu, Jianhang Rao, Qiang Zhu & Kuangbiao Liao*. Artificial Intelligence-Driven Development of Nickel-Catalyzed Enantioselective Cross-Coupling Reactions. ACS Catal. 2024, 14, 18457.

11.An Lin, Jingyuan Liu, Yougen Xu, Haiting Wu, Yating Chen, Yan Zhang, Lebin Su*, Xiaodan Zhao & Kuangbiao Liao*. High-throughput experimentation and machine learning-promoted synthesis of α-phosphoryloxy ketones via Ru-catalyzed P(O)OH insertion reactions of sulfoxonium ylides. Sci. China Chem. 2024, https://doi.org/10.1007/s11426-024-2313-5

12.Chonghuan Zhang, Qianghua Lin, Biwei Zhu, Haopeng Yang, Xiao Lian, Hao Deng, Jiajun Zheng & Kuangbiao Liao*. SynAsk: Unleashing the Power of Large Language Models in Organic Synthesis. Chem. Sci. 2024, https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc04757e

13.Xin Hong, Qi Yang, Kuangbiao Liao, Jianfeng Pei, Mao Chen, Fanyang Mo, Hua Lu, Wen-Bin Zhang, Haisen Zhou, Jiaxiao Chen, Lebin Su, Shuo-Qing Zhang, Siyuan Liu, Xu Huang, Yi-Zhou Sun, Yuxiang Wang, Zexi Zhang, Zhunzhun Yu, Sanzhong Luo, Xue-Feng Fu, Shu-Li You. AI for organic and polymer synthesis. Sci. China Chem. 2024, 67, 2461-2496.

14.一种由尿素衍生物制备1-萘胺类化合物的方法及其预测模型. 中国. ZL 2023 1 0307448.7. 2023年07月18日. 廖矿标，苏乐斌