【个人简介】
康战方，男，广州医科大学附属清远医院（清远市人民医院）肾病中心实验室副研究员。香港中文大学医学院内科与药物治疗系博士。广东省杰出青年医学人才。中国老年医学学会基础与转化医学分会常务委员。多年来一直从事内分泌代谢及泌尿系统领域相关的研究。主要涉及膀胱功能障碍、泌尿系统肿瘤、肥胖及糖尿病等疾病的发病机理及药物治疗。主持及参与多项基金项目，包括国家自然科学基金、广东省自然科学基金等。迄今为止发表多篇SCI论文，其中包括Nature Communications,Diabetologia, FASEB J, Eur J Pharmacol. 等国际期刊在内, 并参与取得多项国内外发明专利。
【研究方向】
药理学
【科研项目】
1. 广东省自然科学基金面上项目，组蛋白去甲基化酶KDM6A在AR靶向治疗耐药性前列腺癌中的作用和机制研究（2026A1515010674），2026-01-01至2028-12-31，10万，在研，主持。
2. 广东省医学科研基金面上项目，4-HNE 羰基化 PPARγ调节胰岛β细胞肠促胰岛素反应的机制及应用研究（A2026055），2026-07-1至2028-06-30，1万，在研，主持。
3. 广东省自然科学基金省企联合项目，树突状细胞高表达GRB2通过增强免疫逃逸介导乳腺癌转移的机制研究（2025A1515220056），2025-12-01 至2028-11-30，10万，在研，主要参与者。
4. 广东省中医药局面上项目，柚皮素上调胰岛β细胞 GLP-1 受体信号通路的机制及应用研究（20251479），2025-01-01 至2026-12-31，0.5万，在研，主持。
5. 广州医科大学附属第六医院（清远市人民医院）开放课题重点项目：以核受体RORgamma为靶标的抗晚期前列腺癌作用机制及创新药物研究（202301-212），2023-02-28 至2027-01-31，50万,在研，主持（院内）。
6. 国家自然科学基金青年项目, PPARα调节肾脏GLP-1受体信号通路在糖尿病肾病中的机理及应用研究（81300680），2014-01-01至2016-12-31，23万，结题，主持。
【代表性论文及著作】
1. Lin Chen#, Zhanfang Kang#, Ziyi Li, Jennifer Hardfeldt, Matteo Pedrelli, Qi Li, Ruining Lyu, Philipp Valina Allo, Xiangru Zheng, Peibin Lin, Jianwen Zeng, Zhiqiang Huang, Oihane Garcia-Irigoyen, Paolo Parini, Amélie Bonnefond, Bo Angelin, Eckardt Treuter, Rongrong Fan*. Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes. Nature Communications. 2026 Mar 23;17(1):3945. doi: 10.1038/s41467-026 -70846-w.
2. Renshan Liang#, Peibin Lin#, Dazhong Yin, Ping Wei*, Zhanfang Kang*. 4-HNE induces cell death through the VCP-related ubiquitination pathway in diabetic cardiomyopathy and the protective effect of metformin. Free Radical Research. 2026 Mar;60(3):270-288. doi: 10.1080/10715762.2026.2665462. Epub 2026 May 8.
3. Sicheng Fu#, Chunju Yang#, Zhiping Liang, Lin Zhong, Shufeng Ji, Yuanxiang Wang, Junjian Wang, Zhanfang Kang*, Junguo Bu*, Hong Wang*. O-GlcNAcylation of NSD2 promotes lung metastasis of triple-negative breast cancer through extracellular matrix remodeling. Biochem Biophys Res Commun. 2026 May 26:827:154043. doi: 10.1016/j.bbrc.2026.154043. Epub 2026 May 26.
4. Chaofan Wang#, Jieying Lin#, Junping Pei#, Zhanfang Kang, Zhouheng Liu, Junwei Li, Guodi Cai, Yang Zhou, Junjian Wang*, Hong Wang*, Xiaoyun Lu*. Discovery of a Potent RXRγ Degrader WCF-598 for the Treatment of Castration-Resistant Prostate Cancer. Journal of Medicinal Chemistry. 2026 Apr 9;69(7):8075-8093. doi: 10.1021/acs.jmedchem.5c03442.
5. Xiaojing Zhang#, Zhijie Liu#, Baojian Guo, Qingbin Cui, Jun Gao, Zhanfang Kang*, Guanghui Xiao*. Pharmacological Mechanisms of Periplocae Cortex Against Congestive Heart Failure Based on Network Pharmacology and Experimental Evaluation. Natural Product Communications. 2024 Mar 20. Volume 19(3): 1–16. DOI: 10.1177/1934578X241229289.
6. Peibin Lin#, Xiaojing Zhang#, Baoyi Zhu#, Jun Gao, Dazhong Yin, Jianwen Zeng*, Zhanfang Kang*. Naringenin protects pancreatic β cells in diabetic rat through activation of estrogen receptor β. Eur J Pharmacol. 2023 Dec 5:960:176115.
7. Xiaojing Zhang#*, Ximin Wu#, Huihui Hu#, Xiaoping Liu, Zhanfang Kang*, Xin Deng*. DT-010 exerts cardioprotective effects by regulating the crosstalk between the AMPK/PGC-1a pathway and ERp57. Cardiovascular therapeutics, 2023 Feb 10:2023:8047752.
8. Xiaojing Zhang#, Baoyi Zhu#, Peibin Lin#, Xiaoping Liu, Jun Gao, Dazhong Yin, Jianwen Zeng*, Baojian Liao*, Zhanfang Kang*. Niacin exacerbates b cell lipotoxicity in diet-induced obesity mice through upregulation of GPR109A and PPARg2: Inhibition by incretin drugs. Front Endocrinol (Lausanne). 2022 Dec 7;13:1057905. doi: 10.3389/fendo.2022.1057905. eCollection 2022.
9. Zhanfang Kang#, Feng Chen#, Wanhui Wu, Rui Liu, Tianda Chen, Fang Xu*. UPRmt and coordinated UPRER in type 2 diabetes. Front. Cell Dev. Biol. 2022 Sep 16;10:974083. doi: 10.3389/fcell.2022.974083.
10. Zhanfang Kang#, Rongrong Fan*. PPARα and NCOR/SMRT Corepressor Network in Liver Metabolic Regulation. FASEB Journal. 2020; 34:8796–8809.
11. Xinglian Mai#, Fuyang Zhou#, Peibin Lin , Shuyun Lin, Jun Gao , Yuhua Ma , Rongrong Fan , Weijen Ting, Chihyang Huang, Dazhong Yin*, Zhanfang Kang*. Metformin Scavenges Formaldehyde and Attenuates Formaldehyde-Induced Bovine Serum Albumin Crosslinking and Cellular DNA Damage. Environmental Toxicology. 2020;35(11):1170-1178.
12. Zhanfang Kang#*, Jianwen Zeng#, Tian Zhang, Shuyun Lin, Jun Gao, Chonghe Jiang, Rongrong Fan, Dazhong Yin*. Hyperglycemia induces NF-κB activation and MCP-1 expression via downregulating GLP-1R expression in rat mesangial cells: inhibition by metformin. Cell Biol Int. 2019 43:940-953.
13. Zhanfang Kang#, Yi Deng, Rongrong Fan, Juliana C. N. Chan, D Ross Laybutt, Gang Xu*. Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes. Diabetologia, 2013 56:423-433.
(Commentary: Lipotoxicity impairs incretin signaling. Diabetologia, 2013 56:231-233)
【所获荣誉和奖励】
1.2018年荣获广东省杰出青年医学人才;
