袁中文，男，副主任中药师，博士。

毕业院校：澳门科技大学（中药质量研究国家重点实验室）  工作单位：附属第三医院

【联系邮箱】zhwyuan1985@163.com

【研究方向】代谢性疾病药理；临床化学分析

【主要科研项目】

(1) 国家自然科学基金青年项目，81803689，21万元，主持，结题

(2) 广东省自然科学基金博士启动项目，2018A030310292，10万元，主持，结题

(3) 贺林院士新医学科研基金，2021HLKY10，20万元，主持，在研

【所获荣誉和奖励】

广州医科大学附属第三医院 “毅文人才工程” 扬帆计划培养对象

【主要论文及著作（代表性）】

(1) Yuan ZhongWen#, Li YaZhuo#, Liu ZhongQiu, Feng SenLing, Zhou Hua, Liu ChangXiao, Liu Liang*, Xie Ying*. Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies[J]. Pharmacological Research, 2018, 128:153-166.

(2) Zhong-Wen Yuan, Elaine Lai-Han Leung, Xing-Xing Fan, Hua Zhou,Wen-Zhe Ma, Liang Liu*, Ying Xie*. Quantitative evaluation of berberine subcellular distribution and cellular accumulation in non-small cell lung cancer cells by UPLC–MS/MS[J]. Talanta, 2015, 144:20-8.

(3) Cao L#, Jin H#, Liang Q, Yang H, Li S, Liu Z, Yuan Z*. A new anti-tumor cytotoxic triterpene from Ganoderma lucidum[J]. Nat Prod Res. 2021, 20:1-7.

(4) Zhang J#, Jin HL#, Jian FB, Feng SL, Zhu WT, Li LH, Yuan ZW*. Evaluation of lipid metabolism imbalance in HIV-infected patients with metabolic disorders using high-performance liquid chromatography-tandem mass spectrometry[J]. Clin Chim Acta. 2022; 526: 30-42.

(5) Feng S#, Zhang J#, Liang B, Jin H, Yuan Z*. Effects of Cyclocarya paliurus flavonoid extract in non-alcoholic steatohepatitis mice: Intermeshing network pharmacology and in vivo pharmacological evaluation[J]. Phcog Mag 2021;17:765-73.

(6) Chang Qu#, Zhong-Wen Yuan#, Xiu-Ting Yu#, Yan-Feng Huang, Guang-Hua Yang, Jian-Nan Chen, Xiao-Ping Lai, Zi-Ren Su, Hui-Fang Zeng*, Ying Xie*, Xiao-Jun Zhang*. Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism[J]. Pharmacological Research, 2017, 121:70-82.

(7) Xiao-Jun Zhang# , Zhong-Wen Yuan#, Chang Qu , Xiu-Ting Yu, Tao Huang, Ping Vicky Chen, Zi-Ren Su, Yao-Xing Dou , Jia-Zhen Wu, Hui-Fang Zeng*, Ying Xie*, Jian-Nan Chen*. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota[J]. Pharmacological Research, 2018, 137: 34-46.

(8) Bi Xiaoli#, Yuan Zhongwen#, Qu Biao, Zhou Hua, Liu Zhongqiu, Xie Ying*, Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2[J]. Phytomedicine, 2019, 54: 98-108.

(9) Rinkiko Suguro#, Xiao-cong Pang#, Zhong-wen Yuan#, Si-yao Chen, Yi-ZhunZhu, YingXie*. Combinational applicaton of silybin and tangeretin attenuates the progression of non-alcoholic steatohepatitis (NASH) in mice via modulating lipid metabolism[J]. Pharmacological Research, 2020, 151:104519.

授权发明专利

(1) 袁中文, 冯森玲, 严鹏科; 一种治疗非酒精性脂肪肝的组合物及用途, 2022-02-11, 中国,  ZL202010464568.4.