【个人简介】
谢慧，女，博士，主任药师，硕士研究生导师。广州医科大学附属第一医院药学部/教研室副主任，广州医科大学临床药学系办公室副主任。华中科技大学药学专业学士，中国科学院大学药物化学博士，新加坡国立大学访问学者。广州市高层次青年后备人才、广州市高层次卫生医学骨干人才，广东省杰出青年医学人才。
社会任职：广州市医学会中青年学术委员会副主任委员，广东省药理学会科学普及专委会副主任委员、广东省药理学会药物代谢专委会常务委员、广东省药理学会临床合理用药常务委员、广东省药学会个体化药学服务专委会常务委员、广东省药学会医药药学品质管理专委会常务委员、广东省医学会临床药学专委会青年委员。
【联系邮箱】brennan_huixie@126.com
【研究方向类别】临床药学（临床药理学）
【具体研究方向】1.基于模型的精准给药及临床应用；2.药物代谢动力学及药物临床前/临床评价
【主要科研项目】
1.广东省教育厅生物医药与健康重点领域专项，2024ZDZX2058，主持，15万；
2.广州医科大学重大临床研究项目，GMUCR2024-01008，subPI，135万；
3.广州医科大学科研能力提升项目，2024SRP069，主持，15万；
4.广东省教育厅高等教育科学研究，2023GXJK437，主持，3万；
5.广州市科技局市校联合，202102010323，主持，20万；
6.广东省自然科学基金，2017A030313885，主持，10万；
7.国家自然科学基金青年基金，81402795，主持，23万，等。
【主要论文及著作（代表性）】
1.Huang Y, Zhou Y, Liu D, Chen Z, Meng D, Tan J, Luo Y, Zhou S, Qiu X, He Y, Wei L, Zhou X, Chen W, Liu X, Xie H. Comparison of Population Pharmacokinetic Modeling and Machine Learning Approaches for Predicting Voriconazole Trough Concentrations in Critically Ill Patients. International Journal of Antimicrobial Agent. 2024.
2.Lin X, Zhao X, Yang B, Huang Y, Zhang R, Li M, Xiao M, Xie H. Determination of a novel anti-influenza pinanamine-based analog in rat plasma by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic evaluations. Sep Sci plus. 2024;7:e2300193.
3.Zeng S, Dou W, Li M, Zhou Y, Guo J, Zhao N, Huang H, Zhou Q, Hu W, Ma Y, Zhao X, Xie H. Discovery of an Orally Active and Long-Acting DPP-IV Inhibitor through Property-Based Optimization with an in Silico Biotransformation Prediction Tool. ChemMedChem. 2020 Aug 19;15(16):1608-1617.
4.Hui Xie, Shaogao Zeng, Yuwen He, Guicheng Zhang, Pengjiu Yu, Guifa Zhong, Hongjiang Xu, Ling Yang, Shanchun Wang, Xin Zhao, Wenhui Hu, Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation. European Journal of Medicinal Chemistry,2017, 141, 519-529.
5.Jifeng Deng, Jiayin Guo, Renke Dai, Guicheng Zhang,Xie H*, Determination of a novel dipeptidyl peptidase IV inhibitor in monkey plasma by HPLC–MS/MS and its application in a pharmacokinetics study.Journal of Pharmaceutical and Biomedical Analysis,2016,117, 99-103.
6.Zhengtu Li#, Runfeng Li#, Jing Li#,Hui Xie#,Yanbing Hao, Qiuling Du, Tingting Chen, Yimin Li, Rongchang Chen, Zifeng Yang*, Nanshan Zhong*Efficacy of delayed treatment of China-made Peramivir with repeated intravenous injections in a mouse influenza model: from clinical experience to basal experiment.BMC Infect Dis.2016; 16: 325-32.
7.Chen W#,Xie H#, Liang F, Meng D, Rui J, Yin X, Zhang T, Xiao X, Cai S, Liu X*, Li Y*, Population Pharmacokinetics in China: The Dynamics of Intravenous Voriconazole in Critically Ill Patients with Pulmonary Disease.biological and pharmaceutical bulletin.,2015;38(7):996-1004.
8.Deng J, Liu P, Lv B, Guo J, Liang F, Tang J,Xie H*, A rapid and sensitive HPLC-MS/MS method for determination of an aminopyridazine derived anti-neuroinflammatory agent (ZW14) in dog plasma: Application to a pharmacokinetic study.Journal of Pharmaceutical and Biomedical Analysis,2015,7, 204-208.
9.Xie, H.; Zeng, L.; Zeng, S.; Lu, X.; Zhao, X.; Zhang, G.; Tu, Z.; Xu, H.; Yang, L.; Zhang, X.; Wang, S.*; Hu, W.*, Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization.European Journal of Medicinal Chemistry,2013, 68, 312-320.
10.Zeng, S.#;Xie, H.#; Zeng, L.; Lu, X.; Zhao, X.; Zhang, G; Tu, Z.; Xu, H.; Yang, L.; Zhang, X.; Hu, W.*, Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization.Bioorganic & Medicinal Chemistry,2013,21 (7), 1749-1755.
11.Xie, H.; Zeng, L.; Zeng, S.; Lu, X.; Zhang, G.; Zhao, X.; Cheng, N.; Tu, Z.; Li, Z.; Xu, H.; Yang, L.; Zhang, X.; Huang, M.; Zhao, J.*; Hu, W.*, Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization.European Journal of Medicinal Chemistry,2012,52, 205-212.
