朱雯婷,广州医科大学附属第三医院,副主任药师,医学博士,毕业于南方医科大学。广东省精准医学应用学会精准用药分会委员、广东省精准医学应用学会青年博士联盟委员,广州市医院协会药学专业工作分会委员,广东省药学会免疫抑制药学专家委员会常务委员。主持等广州市科技局,贺林院士基金,广东省中医药局科研基金等科研项目4项,以第一作者发表SCI论文7篇,累计影响因子超30分。
联系邮箱:zhuwenting456@126.com
研究方向:药物抗肿瘤药理及靶向递送系统
主要科研项目
(1) 贺林院士科研基金,靶向纳米药物介导糖代谢重编程重塑肿瘤微环境逆转肿瘤多药耐药的研究,2022-01至2024-12,20万元,在研,主持;
(2) 广东省中医药局科研项目,基于AKT/mTOR信号通路调控有氧糖酵解的白藜芦醇逆转肿瘤多药耐药的研究,2022-01至2023-12,0.5万元,在研,主持;
(3) 广州市科技局基础与应用基础研究项目,PH响应性的ATF纳米药物诱导肿瘤血管正常化治疗三阴性结直肠癌,2021-04至2023-03,5万元,在研,主持;
(4) 广州市卫生健康一般引导项目,20201A011096,联合免疫检查点抑制剂及肿瘤微环境响应的纳米靶向药物治疗结直肠癌的研究,2020-05至2022-04,1.5万元,在研,主持;
(5) 广州医科大学附属第三医院博士启动基金项目,2018B06,ATF肽和适配体双靶向共载阿霉素/siRNA纳米给药系统治疗三阴结直肠癌的研究,2019-01至2020-12,5万元,结题,主持;
主要论文及著作(代表性)
(1) Zhu WT#, Liu SY#, Wu L, Xu HL, Wang J, Ni GX*, Zeng QB*. Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer. INT J NANOMED. 2017;12:2621-2634. (IF=4.37)
(2) Liu XM#, Zhu WT#, Jia ML, Li YT, Hong Y, Liu ZQ*, Yan PK*. Rapamycin liposomes combined with 5-Fluorouracil inhibits angiogenesis and tumor growth of APC (Min/+) mice and AOM/DSS-induced colorectal cancer mice. INT J NANOMED. 2022.17:5049-5061. (IF=7.1)
(3) Chen YQ#, Zhu WT#, Lin CY, Yuan ZW, Li ZH, Yan PK*. Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer. INT J NANOMED. 2021;16:269-281. (IF=6.40)
(4) Chen LD#, Zhu WT#, Cheng YY, Li ZH, Chen YQ, Yuan ZW, Lin CY, Jing DD, Liu ZQ*, Yan PK*. T-cell death-associated gene 8 accelerates atherosclerosis by promoting vascular smooth muscle cell proliferation and migration. ATHEROSCLEROSIS. 2020;297:64-73. (共同第一作者,IF=5.162)
(5) Mao Z#, Wen-Ting Z#, Hai-Tao W, Hui Y, Shi-Yi L, Jiang-Ping X*, Wen-Ya W*. AMI, an Indazole Derivative, Improves Parkinson's Disease by Inhibiting Tau Phosphorylation. FRONT MOL NEUROSCI. 2020;13:165. ( IF=5.639)
(6) Liu SY#, Zhu WT#, Chen BW, Chen YH, Ni GX*. Bidirectional association between metabolic syndrome and osteoarthritis: a meta-analysis of observational studies. DIABETOL METAB SYNDR. 2020;12:38. (IF=2.89)
(7) Xiao-Feng L#, Wen-Ting Z#, Yuan-Yuan X, Chong-ATF L, Lu Z, Jin-Jun R*, Wen-Ya W*. Protective role of 6-Hydroxy-1-H-Indazole in an MPTP-induced mouse model of Parkinson's disease. EUR J PHARMACOL. 2016;791:348-354.(IF=2.93)