李莹，女，教授，博士生导师，“南山学者”骨干人才，深圳市海外高层次人才。2015年获得华中科技大学博士学位（优秀毕业生），2013-2015年国家纳米科学中心联合培养博士；2015-2019年香港科技大学唐本忠院士团队博士后，2019-2022深圳大学“AIE研究中心”副研究员，2022年5月加入广州医科大学药学院，为药学院“AIE药剂生物学创新研究中心”执行负责人（中心于7月成立）。研究工作主要致力设计、开发应用于多药耐药（MDR）菌感染和癌症疾病诊疗的新型聚集诱导发光（AIE）材料，并探究其相关治疗机理。目前已在国际权威SCI期刊发表科研论文53篇，其中以一作/通讯作者在Nat. Commun., Sci. Adv., Adv. Mater., Angew. Chem. Int. Ed., Adv. Funct. Mater., Adv. Sci., ACS Nano等期刊发表研究论文27篇（IF >10, 21篇），其中2篇选为封面文章，论文被引用2000余次。申请7项中国专利（3项已授权）、1项美国专利；主持了国家自然科学基金青年科学基金/面上项目、深圳市基础研究重点项目和广州医科大学“高水平大学建设项目”人才启动项目；是Adv. Funct. Mater.，Biomaterials，Dyes Pigments等期刊独立审稿人。

联系邮箱：liying5797@126.com

研究方向

1. 病原菌/肿瘤标志物检测

2. AIE光敏剂、AIE纳米药物的合成与应用（肿瘤/耐药病原菌感染诊疗）

3. 宿主导向抗菌药物设计及机理研究；

4. 近红外 II 区功能荧光分子在药物示踪和干细胞治疗过程追踪及协同治疗；

主要科研项目

1. 用于细菌介导肿瘤诊疗的近红外荧光体系的构建及应用研究。项目编号：22275040，国家自然科学基金面上项目，2023.01-2026.12 54万 主持。

2. 广州医科大学“高水平大学建设项目”人才启动项目 项目编号：02-412-2202-2137，2022.05-2027.05 200万 主持。

3. 用于胞内耐药致病菌感染诊疗的聚集诱导发光体系的构建与应用研究。 项目编号：22005195，国家自然科学基金青年科学基金，2021.01-2023.12 24万 主持。

4. 基2020N392肿瘤靶向分子成像及诊疗一体化荧光探针的应用研究。项目编号：JCYJ20200109110608167，深圳市基础研究（重点项目）2020.11-2023.11 250万 主持。

主要论文及著作（代表性）

1. Y. Li,# F. Liu,# J. J. Zhang, X. Y. Liu, P. H. Xiao, H. T. Bai, S. Chen, D. Wang, S. H. P. Sung, R. T. K. Kwok, J. Z. Shen, K. Zhu,* B. Z. Tang* Efficient Killing of Multidrug-Resistant Internalized Bacteria by AIEgens in Vivo. Adv. Sci. 2021, 2001750. (IF = 17.521) (封面)

2. Y. Li,# R.B. Tang,# X.Y. Liu, J.Y. Gong, Z. J. Zhao, Z. H. Sheng, J. J. Zhang, X. Y. Li, G. L. Niu, R. T. K. Kwok, W. F. Zheng,* X.Y. Jiang,* B. Z. Tang*Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers. ACS Nano 2020, 14, 16840-16853. (IF = 18.027)

3. Y. Li,# Z. Zhao,# J. J. Zhang,R. T. K. Kwok, S. Xie, R. B. Tang, Y. X. Jia, J. C. Yang, L. Wang, J. W. Y. Lam, W. F. Zheng,* X. Y. Jiang,* B. Z. Tang* A Bifunctional Aggregation-induced Emission Luminogen forMonitoring and Killing of Multidrug-resistant Bacteria.Adv. Funct. Mater. 2018, 201804632. (IF = 19.927)

4. Y. Li, Y. Tian, W. S. Zheng, Y. Feng, R. Huang, J. X. Shao, R. B. Tang, P. Wang, Y. X. Jia, J. J. Zhang, W. F. Zheng,* G. Yang,* X. Y. Jiang*Composites of Bacterial Cellulose and Small Molecule-Decorated Gold Nanoparticles for Treating Gram-Negative Bacteria-Infected Wounds.Small 2017, 201700130. (IF = 15.153)

5. Y. Li, K. Jiang, J. Feng, J. Z. Liu, R. Huang, Z. J. Chen, J. C. Yang, Z. H. Dai, Y. Chen, N. X. Wang, W. J. Zhang, W. F. Zheng,* G. Yang,* X. Y. Jiang*Construction of small-diameter vascular graft by shape-memory and self-rolling bacterial cellulose membrane.Adv. Healthc. Mater. 2017, 1601343. (IF = 11.092)

6. W. P. Zhu,# Y. Li,# S. X. Guo, W. J. Guo, T. K. Peng, H. Li, B. Liu, H. Q. Peng,* B. Z. Tang* Stereoisomeric Engineering of Aggregation-Induced Emission Photosensitizers towards Fungal Killing. Nat. Commun. 2022, 13, 7046. (IF = 17.694) (Nature Press)

7. J. J. Zhang,# Y. Li,# F. L. Chai,# Q. Z. Li, D. Wang, L. P. Liu,* B. Z. Tang,* X. Y. Jiang* Ultrasensitive Pointof-Care Biochemical Sensor Based on Metal-AIEgen Frameworks. Sci. Adv. 2022, 8, eabo1874. (IF = 14.957) (Science Press)

8. R. H. Dong,# Y. Li,# M. Chen, P. H. Xiao, Y. F. Wu, K. Zhou, Z. Zhao,* B. Z. Tang* In Situ Electrospinning of Aggregation-Induced Emission Nanofibrous Dressing for Wound Healing. Small Methods 2022, 2101247. (IF = 15.367)

9. X.-M. Cai,# Y. T. Lin,# Y. Li,# X. F. Chen, Z. Y. Wang, X. Q. Zhao, S. L. Huang,* Z. Zhao,* B. Z. Tang* BioAIEgens Derived from Rosin: How Does Molecular Motion Affect Their Photophysical Processes in Solid State? Nat. Commun. 2021, 12, 1773. (IF = 17.694) (Nature Press)

10. Z. Hu,# Y. Li,# M. M. Kang, M. M. Islam, M. S. Chen, J. Zhang, Y. Xiao, X. Feng,* C. Redshaw, M. L. Zhang,* Q. Chen, S. Xie* J. W. Y. Lam, B. Z. Tang*Aggregation-Induced Emission Luminogen: A New Perspective in the Photo-Degradation of Organic Pollutants. EcoMat 2020, e12024. (IF = 12.213) (封面)

11. Q. Y. Li, # Y. Li,# T. L. Min,# J. Y. Gong, L. L. Du, K. Li, D. L. Phillips, J. K. Liu, J. W. Y. Lam, H. H. Y. Sung, I. D. Williams, R. T. K. Kwok, J. G. Wang,* B. Z. Tang*Time-dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE-active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation. Angew. Chem. Int. Edit. 2019, 59, 9470-9477. (IF =16.823)

12. X. Feng,# Y. Li,# X. W. He, H. X. Liu, Z. Zhao, R. T. K. Kwok, M. R. J. Elsegood, J. W. Y. Lam, B. Z. Tang* A Substitution-dependent Light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application. Adv. Funct. Mater. 2018, 1802833. (IF = 19.927)

13. Z. P. Shen, W. Zhu, Y. J. Huang, J. J. Zhang, Y. F. Wu, Y. Z. Pan, G. Yang, D. Wang,* Y. Li,* B. Z. Tang,* Visual Multifunctional Aggregation-induced emission-Based Bacterial Cellulose for Killing of Multidrug-resistant Bacteria. Adv. Healthc. Mater. 2023, 202300045. (IF = 11.092)

14. Y. S. Lin, M. M. Yi, X. L. Guan, S. Chen, L. Y. Yang, S. P. Li,* Y. Li,* L. M. Zhang,* “Two birds with one stone” strategy for the lung cancer therapy with bioinspired AIE aggregates. J. Nanobiotechnol. 2023, 21, 49. (IF = 9.429)

15. W.-J. Wu, T. K. Peng, W. P. Zhu, S. X. Ma, G. Wang, Y. Li,* B. Liu, H.-Q. Peng,* Visualization of Supramolecular Assembly by Aggregation-Induced Emissionm.Aggregate. 2022, e297.

16. Y. F. Wu, J. G. Li, Z. P. Shen, D. L. Wang, R. H. Dong, J. J. Zhang, Y. Z. Pan, Y. Li, * D. Wang, * B. Z. Tang,* Double‐pronged Antimicrobial Agents based on a Donor‐π‐Acceptor Type Aggregation‐

Induced Emission Luminogen. Angew. Chem. Int. Edit. 2022, 202212386. (IF = 16.823)

17. J. Y. Gong, P. F. Wei, J. K. Liu, Z. Zhao, W. J. Zhao, C. Ma, J. W. Y. Lam, K. S. Wong, Y. Li,* B. Z. Tang* Polarity-triggered anti-Kasha syatem for high-contrast cell imaging and classification. Aggregate. 2022, e265.

18. X. H. Wang, M. R. Song, Y. W. Liu, X. Feng,* D. Wang, C. Redshaw, K. Zhu, Y. Li,* B. Z. Tang,* Lipid Droplet-specific Red Aggregation-induced Emission Luminogens: Fast Light-up of Gram-positive pathogens for Identification of Bacteria. ACS Materials Lett. 2022, 4, 1523-1530. (IF = 11.171)

19. P. H. Xiao, Z. P. Shen, D. L. Wang, Y. Z. Pan, Y. Li,* , J. Y. Gong, L. Wang, D. Wang,* B. Z. Tang*Precise Molecular Engineering of Type I Photosensitizers with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Killing of Multidrug-Resistant Bacteria. Adv. Sci. 2022, 9, 2104079. (IF = 17.521)

20. H. X. Li, W. Zhu, M. Li, Y. Li,* R. T. K. Kwok, J. W. Y. Lam, L. Wang, D. Wang,* B. Z. Tang* Side Area-Assisted 3D Evaporator with Antibiofouling Function for Ultra-Efficient Solar Steam Generation. Adv. Mater. 2021, 2102258. (IF = 32.086)

21. X. J. Shi, S. H. P. Sung, J. H. C. Chau, Y. Li,* Z. Y. Liu, R. T. K. Kwok,* J. K. Liu, P. H. Xiao, J. J. Zhang, B. Liu, J. W. Y. Lam, B. Z. Tang* Killing G (+) or G (−) Bacteria? The Important Role of Molecular Charge in AIE-Active Photosensitizers. Small Methods 2020, 2000046. (IF = 15.367)