肖青,女,博士,药理学副教授,硕士研究生导师。2012年于广州医科大学药理教研室任职,担任教学和科研工作。主要从事心脏病理性重构的机制与靶点研究。目前主要从事蛋白翻译后修饰与心脏疾病的研究。作为项目负责人主持国家自然科学基金1项及省级课题多项。以第一作者/通讯作者在Cardiovascular research、Frontiers in pharmacology等杂志发表SCI论文多篇。
联系邮箱:xiaoqingxiaomeng@163.com
研究方向:心脏病理性重构的机制与靶点研究
承担课题:
1,广东省自然科学基金项目 Ubc9双靶点调控自噬流在急性心肌梗死损伤中的作用及机制研究,2021/01-2023/01,10万,在研,主持。
2,广东省省级科技计划项目 Netrin-1基因双靶点促进骨髓内皮祖细胞移植对心肌梗死的治疗作用及机制研究,2017/01-2020/01,10万,结题,主持。
3,广东省医学科学技术研究基金项目 内皮祖细胞自噬通路受损在糖尿病合并心肌梗死中的作用研究,2015/07-2017/07,0.5万,结题,主持。
4,广东省省级科技计划项目 内皮祖细胞自噬通路受损在糖尿病合并心肌梗死中的作用研究,2015/01-2016/12,10万元,结题,主持。
5,国家自然科学基金青年项目 内皮祖细胞Sonic hedgehog通路受损在糖尿病合并心肌梗死中的作用及机制研究,2014/01-2016/12,23万元,结题,主持。
部分论著列表:
1. Qing Xiao, Qimeng Liu, Ruchao Jiang, Kaifeng Chen, Xiang Zhu, Fei He, Junjun Huang. Piperazine-derived α1D/1A antagonist 1- benzyl-N- (3-(4- (2-methoxyphenyl) piperazine-1-yl) propyl) -1H- indole-2- carboxamide induces apoptosis in benign prostatic hyperplasia independently of α1-adrenoceptor blocking. Front Pharmacol. 2021 Jan 27; 11: 594038.
2. Xiao Q, Chen XH, Jiang RC, Chen SY, Chen KF, Zhu X, Zhang XL, Huang JJ, Qin Y, Zhang GP, Yi Q, Luo JD. Ubc9 Attenuates Myocardial Ischemic Injury Through Accelerating Autophagic Flux. Front Pharmacol. 2020 Sep 15; 11: 561306.
3. Jiang RC, Zhang XL, Zhang QA, Zheng XY, Shi HJ, Qin Y, Zhang GP, Xiao Q, Luo JD. Impaired Vps34 complex activity-mediated autophagy inhibition contributes to endothelial progenitor cells damage in the ischemic conditions. Biochem Biophys Res Commun. 2020 524(3): 629-635.
4. Liu QM, Xiao Q, Zhu X, Chen KF, Liu XW, Jiang RC, Wu D, Shi JM, Dai LJ, Huang JJ. Inhibitory effect of α (1D / 1A) antagonist 2 - (1H - indol - 3 - yl) -N - [3 - (4 - (2 - methoxyphenyl) piperazinyl) propyl] acetamide on estrogen/androgen-induced rat benign prostatic hyperplasia model in vivo. Eur J Pharmacol. 2020 Mar 5; 870: 172817.
5. Xiao Q, Zhao XY, Jiang RC, Chen XH, Zhu X, Chen KF, Chen SY, Zhang XL, Qin Y, Liu YH, Luo JD. Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice. Int J Mol Med. 2019 Sep;44(3): 1091-1105.
6. Xiao Q, Yang Y, Qin Y, He YH, Chen KX, Zhu JW, Zhang GP, Luo JD.AMP-activated protein kinase-dependent autophagy mediated the protective effect of sonic hedgehog pathway on oxygen glucose deprivation-induced injury of cardiomyocytes. Biochem Biophys Res Commun. 2015 Feb 13;457(3): 419-25.
7. QING XIAO, YA YANG, LI‑SHAN HE, YUAN QIN, YAN‑HUA HE, GUI‑PING ZHANG and JIAN‑DONG LUO. Oxidative stress contributes to the impaired sonic hedgehog pathway in type 1 diabetic mice with myocardial infarction. EXPERIMENTAL AND THERAPEUTIC MEDICINE. 2015 Nov;10(5): 1750-1758.
8. Xiao Q, Hou N, Wang YP, He LS, He YH, Zhang GP, Yi Q, Liu SM, Chen MS, Luo JD. Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction. Cardiovascular Research. 2012; 95: 507-516.