【个人简介】

陈沐，男，博士，讲师。2017年毕业于中国医科大学药学院，获理学学士学位。2023年毕业于暨南大学药学院，获医学博士学位，师从王磊研究员、叶文才教授，主要从事中药及天然药物活性成分研究、天然生物活性分子发现的新方法研究。2023年9月加入广州医科大学药学院，现担任药学系药物化学教研室专任教师。主持国家自然科学基金青年基等各类项目5项。目前已在国际主流期刊上发表论文数篇。

【联系邮箱】gzhmucmu@gzhmu.edu.cn

【研究方向类别】

专业学位：工业药学（转化药学）

【具体研究方向】  

中药及天然药物活性成分研究

天然生物活性分子发现的新方法研究

【主要科研项目】

1. 国家自然科学基金青年科学基金，82404472，2025/01至2027/12，主持；

2. 广州市科技局2025年度基础与应用基础研究专题（青年博士“启航”项目），2024A04J00833，2025/01至2026/12，主持；

3. 广州市教育局高校科研项目，2024312081，2025/01至2026/12，主持；

4. 广东省中医药局科研项目，20261227，2026/01至2027/12，主持；

5. 广州医科大学科研能力提升项目，2024/01至2025/12，主持；

6. 国家自然科学基金面上项目，82173859，2022/01至2025/12，参与；

7. 国家自然科学基金面上项目，82074116，2021/01至2024/12，参与。

【主要论文及著作（代表性）】

1. Bao-Ren Huang¹, Mu Chen¹, Jun-Jie Luo, Lei Wang^*, Wen-Cai Ye^*, Ke Wang^*. Mol-ME: Enhancing Molecular Property Prediction via Multi-Modal Alignment Learning and Ensemble Methods. J. Chem. Inf. Model., 2026, 66(16): 9803-9815.

2. Bai-Ting Zhang¹, Mu Chen¹, Yang Huang¹, Siyi Mou, Shu-Lei Qin, Shuo Yang^*, Zheng-Jin Jiang^*, Sheng-Feng Huang^*. Rapid colorimetric assay-guided discovery of α-glucosidase inhibitors from natural products using a MOF-818@Pt nanozyme. Anal. Chim. Acta, 2026, 1417: 345774.

3. Xin-Wei Hu¹, Zai-Mu Cao¹, Mu Chen¹, Chun-Dong Huang, Shao-Fei Ni, Shou-Kun Zhang, Zhi-Xiong Ruan^*. Electrochemical Late-Stage Stitching of Tryptophan Peptides via N-S Bond Formation. Angew. Chem. Int. Ed., 2025, 64: e202517101.

4. Wen-Yan Xu¹, Cheng-Wei Zheng¹, Mu Chen¹, Xin Deng¹, Ling-Min Zhang, Xue-Ping Lei, Lu Liang, Xi-Yong Yu, Xin-Wei Hu^*, Ju-Yun He^*, Shui-Mu Lin^*, Zhi-Xiong Ruan^*. Modular Synthesis of Bioactive Selenoheterocycles for Efficient Cancer Therapy via Electrochemical Selenylation/Cyclization. J. Med. Chem., 2025, 68(6): 6339-6360.

5. Zhen-Zhen Yang¹, Mu Chen¹, Xin-Yi Gao¹, Liang Long, Hai-Wang Yang, Yan Wu, Jun-Cheng Su, Yang Chen^*, Xue-Ping Lei^*, Ji-Hong Gu^*. Acronynoids A-G, novel prenylated acetophenone-based meroterpenoids with angiogenesis inhibitory activities from Acronychia pedunculata. Bioorg. Chem., 2025, 159: 108376.

6. Mu Chen¹, Jia-Qing Cao¹, Song Ang¹, Ting-Ni Zeng, Ni-Ping Li, Tang-Jia Yang, Jun-Shan Liu, Yan Wu, Wen-Cai Ye^* and Lei Wang^*. Eugenunilones A–H: Rearranged Sesquiterpenoids from Eugenia uniflora. Org. Chem. Front., 2022, 9(3): 667-675.

7. Mu Chen¹, Run-Qiang Chen¹, Yuan Guo, Jian-Xin Chen, Qian Jin, Mei-Hong Chen, Bo-Yong Chen, Zheng-Chao Tu, Wen-Cai Ye^*, and Lei Wang^*. Eugenilones A-N: Sesquiterpenoids from the Fruits of Eugenia uniflora. Phytochemistry, 2023, 211: 113699.

8. Jia-Yong Liu¹, Jia-Hui Lin¹, Wen-Yi Wang, Hong-Xia Li, Yu-Jiahui Zheng, Yu-Yan Zhang, Mu Chen, Rong-Cui Zhong, Chong Xing, Yuan-Ye Dang, Hui-Li Chang^*, Shou-Ping Liu^*, Shui-Mu Lin^*. Clofoctol-derived amphiphilic peptidomimetics exhibit broadened antimicrobial activity via multiple contributing mechanisms. J. Adv. Res., 2026.

9. Su-Hua Wu, Venkatesh Mayandi, Eunice Tze Leng Goh, Wen-Yi Wang, Nuo-Tong Han, Rong-Cui Zhong, Zhao-Zu Luo, Yue Wang, Mu Chen, Rajamani Lakshminarayanan^*, Zhi-Xiong Ruan^*, Shou-Ping Liu^*, Shui-Mu Lin^*. Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism. J. Adv. Res., 2026, 82: 1189-1202.

10. Bo-Yin Li¹, Yuan-Yu Ke¹, Jin-Hua Zhu¹, Wei-Song Zhang, Ming-Jin Yang, Zhan Li, Mu Chen, Zhi-Ling Liu, Jie-Yao Liu, Qiu-Di Deng^*, Peng Zhang^*, Xue-Ping Lei^*. A fungal‑derived benzothiazole derivative overcomes osimertinib resistance in NSCLC by targeting SCD1. Nat. Product Bioprosp., 2026, 16: 86.

11. Xiao-Tong Song, Mu Chen, Xin-Wei Hu^*, Zhi-Xiong Ruan^*. Base-Catalyzed Hydrothiolation of Dehydroalanine Peptides. J. Org. Chem., 2026, 91(13): 4535-4547.

12. Xin-Wei Hu¹, Cheng-Wei Zheng¹, Xiao-Tong Song, Balati Hasimujiang, Mu Chen, Zhi-Xiong Ruan^*. Manganese-Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides. Adv. Sci. 2025, 12, 2502711.

13. Wan-Shan Li¹, Xue-Ping Lei¹, Zhan Li¹, Yong He, Mu Chen, Zhong-Ping Jiang^*, Guang-Ying Chen^*. Discovery of marine ent-eudesmane sesquiterpenoids as angiogenic inhibitors via suppressing VEGF-A/VEGFR2 signaling pathway. Bioorg. Chem., 2025, 154: 108055.

14. Jin-Yan Zhang¹, Fen Liu¹, Qian Jin, Xue-Yi Li, Qiong Zhan, Mu Chen, Si-Si Wang, Zhen-Long Wu, Wen-Cai Ye^*, Lei Wang^*. Discovery of unusual phloroglucinol-triterpenoid adducts from Leptospermum scoparium and Xanthostemon chrysanthus by building blocks-based molecular networking. Chin. Chem. Lett., 2024, 35(6): 108881.

15. Yu-Heng Huang¹, Xiao-Xin Guo¹, Zhen Wang¹, Cong Yin, Mu Chen, Jia-Ming Xie, Ning Li, Zheng-Chao Tu, Juan Li, Jia-Qing Cao, Zheng-Jin Jiang, Wei-Huan Huang^*, Hai-Yan Tian^*. High-resolution neuraminidase inhibition profiling of Arnebia euchroma (Royle) I.M. Johnst. based on HR-MS and target isolation: An example study of anti-infectious constituents in traditional Chinese medicine. J. Ethnopharmacol., 2024, 319: 117074.