【个人简介】
申翱，博士，广州医科大学南山学者引进人才、药学院副教授、博士研究生导师。
国际心脏研究学会（ISHR）中国分会副秘书长，中国病理生理学会心血管专委会委员，中国药理学会表观遗传药理学专委会委员，广东省药理学会常务理事，广东省药理学会心血管药理专委会常务委员，广东省医学会医学科研实验室建设与管理学分会常务委员，广东省呼吸与健康学会健康与数智化管理专业委员会委员。
武汉大学生命科学学院生物学基地班专业理学学士、武汉大学生命科学学院微生物专业理学博士（医学病毒学方向）、美国加州大学戴维斯分校医学院药理学系博士后（心血管疾病方向）。
曾为美国加州大学伯克利分校公共卫生学院传染病学系访问学者、武汉大学病毒学国家重点实验室讲师。作为课题主持或学术骨干先后获多项国家和省部级级项目资助，如科技部973计划、国家自然科学基金重点项目、面上项目、青年项目、国家留学基金委联合培养博士奖学金、美国心脏学会AHA Postdoctoral Fellowship、广东省自然科学基金面上项目等。在Nature Communications、Science Signaling、APSB、eLife、Pharmacological Research等发表SCI论文超过30篇，授权发明专利8项。
【联系邮箱】
shenao@gzhmu.edu.cn
【研究方向类别】
1、学术学位：药理学
2、专业学位：工业药学（转化药学）
【具体研究方向】
胸腔疾病的分子机制和药理学研究、新药筛选和靶向治疗。
【主要科研项目】
1. 广东省自然科学基金面上项目（主持），项目名称：双靶点广谱抗冠状病毒智能前药的开发及其抗新冠病毒的机制研究
2. 广东省自然科学基金面上项目（主持），项目名称：肺心病时lncRNA Aloha通过抑制AXL-cJUN正反馈回路缓解心肺纤维化的机制研究
3. 国家自然科学基金面上项目（主持），项目名称：β1受体通过二聚体-单体转换引发心力衰竭时β受体信号异常的机制研究
4. 广东省教育厅特色创新类项目（主持），项目名称：心脏中二聚化β1肾上腺素受体的关键作用及其对心力衰竭的影响
5. 广东省自然科学基金面上项目（主持），项目名称：由β受体亚群介导的β受体阻滞剂偏好性信号转导研究
6. 美国心脏协会WSA Postdoctoral Fellowship（主持），项目名称：PKA and GRK phosphorylation define two distinct subpopulations of beta2 adrenoceptor in cardiomyocyte
7. 国家自然科学基金 青年科学基金项目（主持），项目名称：人巨细胞病毒DNA 引发酶UL70 同宿主因子的相互作用研究
【所获荣誉和奖励】
1. 一种新颖的多肽偶联药物策略用于抗冠状病毒感染，硅谷国际发明展银奖（2/6）
2. 人工外泌体类药物改造微环境防治肺源性心脏病，中国产学研合作创新与促进奖 创新成果优秀奖（3/10）
3. 微环境表观遗传调控与外泌体防治肺源性心脏病的拓展研究，华夏医学科技奖 科学技术三等奖（6/8）
4. 一种新颖的基因靶向去甲基化技术，日内瓦国际发明展金奖（2/4）
【主要论文及著作（代表性）】
1. Lixin Zhao#, Yuguang Zhu#, Hua Tao#, Xiying Chen, Feng Yin, Yingyi Zhang, Jianfeng Qin, Yongyin Huang, Bikun Cai, Yonghao Lin, Jiaxiang Wu, Yu Zhang, Lu Liang, Ao Shen*, Xi-Yong Yu*. Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation. Acta Pharmaceutica Sinica B, 2024;14(8):3543-3560,
2. Yinshan Lin#, Xiaoling Guan#, Jianfen Su#, Sheng Chen, Xihua Fu, Xiaowei Xu, Xiaohua Deng, Jishuo Chang, Aiping Qin*, Ao Shen*, Lingmin Zhang*. Cell membrane-camouflaged nanoparticles mediated nucleic acids delivery. International Journal of Nanomedicine, 2023, 18: 8001-8021.
3. Lu Liang#, Wenyan Xu#, Ao Shen#, Huiyu Cen, Xuan-Yu Chen, Lin Tan, Qiuxia Zhu, Zhijun Xiao, Siran Wang, Zhongxiao Lin, Yu Zhang, Lingmin Zhang, Jishuo Chang, Chuwen Li*, Zhe-Sheng Chen*, Xiyong Yu*. Inhibition of YAP1 activity ameliorates acute lung injury through promotion of M2 macrophage polarization. MedComm, 2023, 4(3): e293.
4. Joseph M. Martinez#, Ao Shen#, Bing Xu, Aleksandra Jovanovic, Josephine de Chabot, Jin Zhang, Yang K. Xiang. Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory. Science Signaling, 2023, 16(778):eade3380.
5. Aiping Qin#, Sheng Chen#, Songpei Li#, Qizhen Li, Xiaotao Huang, Luoxing Xia, Yinshan Lin, Ao Shen*, Andy Peng Xiang*, Lingmin Zhang*. Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment. Journal of Nanobiotechnology, 2022, 20(1):335.
6. Lu Liang#, Wenyan Xu#, Ao Shen#, Huiyu Cen, Zhijun Chen, Lin Tan, Lingmin Zhang, Yu Zhang, Jijun Fu, Aiping Qin, Xueping Lei, Songpei Li, Yuyan Qin*, Jionghua Huang*, Xiyong Yu*. Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9. Acta Pharmacologica Sinica, 2022, 43(11):2946-2955.
7. Guanlie Li#, Haiqing He#, Guodong Zheng#, Wenjing Jiang, Shuwen Du, Hua Tao, Tao Xiao, Dazhi Zhou, Shangwei Ding, Xi-Yong Yu, Yu Zhang*, Ao Shen*. Direct detection of pulmonary fibrosis by near-infrared-responsive biomimetic platelets. International Journal of Nanomedicine, 2022, 17: 151-162.
8. Xiang Tao#, Haiqing He#, Jiangtong Peng#, Rui Xu, Jing Fu, Yuting Hu, Li Li, Xiaoyan Yang, Xiuling Feng, Chao Zhang, Lingmin Zhang, Xi-Yong Yu, Ao Shen*, Kai Huang*, Qin Fu*. Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast. Pharmacological Research, 2022, 175:106004.
9. Chuangjia Huang#, Xiaoling Guan#, Hui Lin#, Lu Liang, Yueheng Wu, Xiaodan Wu, Ao Shen*, Minyan Wei*, Jionghua Huang*. Efficient photoacoustic imaging with biomimetic mesoporous silica-based nanoparticles. Frontiers in Bioengineering and Biotechnology, 2021, 9:762956.
10. Xin Huang#, Ao Shen#, Rui Peng#, Sheng Chen, Shitao Lin, Shangwei Ding*, Huan Li*, Dazhi Zhou*. A novel biomimetic nanoprobe as photoacoustic contrast agent. Frontiers in Chemistry, 2021, 9:721799.
11. Ao Shen, Xi-Yong Yu. “Histone lysine demethylase inhibitor (HDMi) as chemo-sensitizing agent”, in Epigenetic Regulation in Overcoming Chemoresistance, 1th Ed, eds Chunfu Wu, Lihui Wang. Elsevier Press, 2021, 41-55. doi: 10.1016/B978-0-12-823684-0.00007-4
12. Ao Shen, Xi-Yong Yu. “Targeting histone lysine methyltransferases for drug sensitization”, in Epigenetic Regulation in Overcoming Chemoresistance, 1th Ed, eds Chunfu Wu, Lihui Wang. Elsevier Press, 2021, 57-67. doi: 10.1016/B978-0-12-823684-0.00003-7
13. Jun Chen, Guanlie Li, Haiqing He, Xin Li, Wenjing Niu, Di Cao, Ao Shen. Sumoylation of the carboxy-terminal of human cytomegalovirus DNA polymerase processivity factor UL44 attenuates viral DNA replication. Frontiers in Microbiology, 2021, 12:652719.
14. Ao Shen, Dana Chen, Manpreet Kaur, Peter Bartels, Bing Xu, Qian Shi, Joseph M. Martinez, Kwun-nok Mimi Man, Madeline Nieves-Cintron, Johannes W. Hell, Manuel F. Navedo, Xi-Yong Yu, Yang K. Xiang. β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons. eLife. 2019, 8: e49464.
15. Ao Shen, Madeline Nieves-Cintron, Yawen Deng, Qian Shi, Dhrubajyoti Chowdhury, Jinyi Qi, Johannes W. Hell, Manuel F. Navedo, Yang K. Xiang. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nature Communications. 2018, 9(1):1050.
16. Tommaso Patriarchi#, Ao Shen#, Wei He, Mo Baikoghli, Holland R. Cheng, Yang K. Xiang, Matthew A. Coleman, Lin Tian. Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. Scientific Reports. 2018, 8(1):3556.
17. Ao Shen#, Ji Lei#, Edward Yang#, Yonggang Pei, Chuan-Yuan Chen, Hao Gong, Gengfu Xiao, Fenyong Liu. Human cytomegalovirus primase UL70 specifically interacts with cellular factor Snapin. Journal of Virology. 2011, 85(22):11732-11741.
18. Yanni Chen, Ao Shen, Paul J. Rider, Yi Yu, Kailang Wu, Yongxin Mu, Qian Hao, Yingle Liu, Hao Gong, Ying Zhu, Fenyong Liu, Jianguo Wu. A liver-specific miRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication. The FASEB Journal. 2011, 25(12): 4511-4521.
