孙平,男,副研究员,本科毕业于四川大学生物工程专业,博士毕业于德国维尔茨堡大学(Julius-Maximilians-Universität Würzburg)医学院生命科学专业。2016年11月入职于广州医科大学药学院。主要从事抗炎小分子药物筛选和药理机制研究,以及所筛选的化合物在阿尔茨海默病、痛风性关节炎、银屑病等炎症相关疾病中的药效研究。
【联系邮箱】josp124@foxmail.com, sun_ping@gzhmu.edu.cn
【研究方向】抗炎小分子筛选以及化合物药理机制研究
【主要科研项目及成果】
1.神经炎症抑制剂AD16对阿尔茨海默病模型APP/PS1双转基因小鼠脑内成体神经再生的影响及机制研究,广东省自然科学基金,2017.1.1-2020.4.1主持
2.神经胶质细胞调节剂AD110延缓阿尔茨海默氏症的作用及机制研究,国家自然科学基金,2019.1-2022.12参与
3.胡文辉、余细勇、孙平、赵昕、吴波;嘧啶哌嗪酰胺类化合物及其应用专利号:ZL:201710591660.5;授权日:2019.9.19
【近几年的主要论文及著作(代表性)】
(1). Deng W#, Yang Z#, Yue H, Ou Y, Hu W*, Sun P*. Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation. Free Radical Biology and Medicine, 2020 May 152:8-17. (通讯)
(2). Ou Y#, Sun P#, Wu N#, Chen H, Wu D, Hu W*, Yang Z*. Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome. Bioorganic & Medicinal Chemistry Letters, 2020, July 127399 (共同一作)
(3). Sun P, Yue H, Xing Q, Deng W, Ou Y, Pan G, Zhong X*, Hu W*. Compound AD16 reduces amyloid plaque deposition and modifies microglia in a transgenic mouse model of Alzheimer's disease. ACS Pharmacology & Translational Science, 2020, Nov 3(6) 1100-1110
(4). Sun P#, Zhou W#, Yue H, Zhang C, Ou Y, Yang Z*, Hu W*. Compound AD110 acts as therapeutic management for Alzheimer's disease and stroke in mouse and rat models. ACS Chemical Neuroscience, 2020 Mar 11(6):929-938.
(5). Sun P, Ortega G, Tan Y, Hua Q, Riederer PF, Deckert J, Schmitt-Böhrer AG*. Streptozotocin impairs proliferation and differentiation of adult hippocampal neural stem cells in vitro-correlation with alterations in the expression of proteins associated with the insulin system. Frontiers in Aging Neuroscience, 2018 May 18;10:145.
(6). Sun P, Knezovic A, Parlak M, Cuber J, Karabeg MM, Deckert J, Riederer P, Hua Q, Salkovic-Petrisic M, Schmitt AG. Long-term effects of intracerebroventricular streptozotocin treatment on adult neurogenesis in the rat hippocampus. Current Alzheimer Research, 2015;12(8):772-84.
(7). Sun P, Hua Q, Schmitt AG. Energy metabolism, adult neurogenesis and their possible roles in Alzheimer’s disease: A brief overview. Current Topics in Medicinal Chemistry. 2016;16(5):493-502.