李松沛、女、副研究员。本科毕业于沈阳药科大学药剂学专业,硕士毕业于日本东邦大学医疗药学专业,博士毕业于澳大利亚皇家墨尔本理工大学补充医学专业。2017年加入广州医科大学药学院进行博士后研究,之后继续在药学院进行教学科研工作。发表学术论文30余篇,其中第一作者和通讯作者(含共同)9篇,主持国家自然科学基金青年项目一项,中国博士后科学基金一项,参与国家自然科学基金面上项目2项。
联系邮箱:lisongpei@foxmail.com
研究方向:心肺疾病的分子药理学及外泌体的应用
主要科研项目
1. 国家自然科学基金委员会, 青年科学基金项目, 81903607, 糖尿病心肌病中HuR调控成纤维细胞分泌导致心肌肥大EVs的机制研究, 2020-01 至 2022-12, 21万元, 已结题, 主持
2. 国家自然科学基金委员会, 面上项目, 82170008, 间充质干细胞仿生纳米粒介导的病毒性肺炎治疗及其作用机制研究, 2022-01 至 2025-12, 54万元, 在研, 参与
3. 国家自然科学基金委员会, 面上项目, 81870142, 间充质干细胞治疗EBV感染性肺炎的抗病毒机制研究, 2019-01至 2022-12, 54万元, 已结题, 参与
主要论文及著作(代表性)
1. Lingmin Zhang#, Yinshan Lin#, Songpei Li#, Xiaoling Guan, Xingyu Jiang*, In Situ Reprogramming of Tumor-Associated Macrophages with Internally and Externally Engineered Exosomes, Angew Chem Int Ed Engl, 2023, 62(11):e202217089
2. Yu-Yan Qin#, Songpei Li#, Aiping Qin#, Yinshan Lin, Jinxian Ye, Yingying Huang, Jianglin Wang, Lu Liang, Xi-Yong Yu*, Lingmin Zhang*, Targeted and Infarcted Microenvironment-Responsive Peptide Therapeutics to Reverse Cardiac Remodeling, Advanced Therapeutics, 2022, 2200121
3. Huan Li#, Songpei Li#, Yinshan Lin, Sheng Chen, Langyu Yang, Xin Huang, Hao Wang, Xiyong Yu*, Lingmin Zhang*; Artificial exosomes mediated spatiotemporal-resolved and targeted delivery of epigenetic inhibitors, J Nanobiotechnology, 2021, 19: 364
4. Yinshan# Lin, Songpei Li#, Zekuan Xiao#, Sheng Chen, Langyu Yang, Qingsheng Peng, Huan Li, Jijun Fu*; Xiyong Yu*; Lingmin, Zhang*; Epigenetic inhibition assisted chemotherapeutic treatment of lung cancer based on artificial exosomes, Pharmacol Res, 2021, 171: 105787
5. Qiudi Deng#, Xueping Lei#, Yihang Zhong, Minshan Chen, Yuanyu Ke, Zhan Li, Jing Chen, Lijuan Huang, Yu Zhang, Lu Liang, Zhongxiao Lin, Qing Liu*, Songpei Li*, Xi-Yong Yu*. Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial-mesenchymal transition, Acta Pharmacol Sin. 2021, 42(9):1486-1497
6. Songpei Li#, Xueping Lei#, Zekuan Xiao, Wenyi Xia, Chaojin Lin, Xiaomei Fu, Jijun Fu, Lingmin Zhang*, Xiyong Yu*, Dihydrotanshinone I ameliorates cardiac hypertrophy in diabetic mice induced by chronic high-fat feeding, Nat Prod Commun. 2020, 15:1-11
7. Songpei Li#, Zhong-Xiao Lin, Xue-Yan Jiang, Xi-Yong Yu*, Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools, Acta Pharmacol Sin, 2018, 39(4): 542-551.