刘夏雯，女，副教授。2013年7月于广州医科大学博士毕业，同年进入广州医科大学药物研发中心工作，科研方向为小分子与代谢酶的相互调控机制研究。承担本科课程《仪器分析》和《卫生化学》及研究生《现代分析技术与实践》中的部分章节。现为广东省药学会药物分析专业委员会委员。已在国际期刊发表科研论文十余篇；申请科研专利一项；主持国家自然科学基金及省市级科研项目多项，作为主要成员参与国家自然科学基金三项、省重点项目一项。
联系邮箱：lxwgzhmu@gzhmu.eud.cn
研究方向：1. 新药开发中药物的体内外药代动力学研究；2. 小分子与代谢酶的相互作用机制研究。
主要科研项目
1. 主持2022年广东省自然科学基金青年提升项目（项目批准编号：2023A1515030041）
2. 主持2020年广州市教育局青年人才科研项目（项目批准编号：202032813）
3. 主持2016年国家自然科学基金青年项目（项目批准号：81503131）
4. 主持2014年广州市属高校科研项目（立项编号：1201430376）
主要论文及著作（代表性）
1. Haoxin Zhan#, Silin Zhang#, Lirong Li, Zikai Chen, Yi Cai, Junjun Huang, Dan Wu, Biyun Huang, Bo Wu*, Xiawen Liu*（共同通讯）, Naftopidil enantiomers suppress androgen accumulation and induce cell apoptosis via the UDP-glucuronosyltransferase 2B15 in benign prostate hyperplasia. Journal of Steroid Biochemistry and Molecular Biology, 2022, 221: 106117.
2. Lei Ma, Junyuan Tang, Guihui Cai, Fangyuan Chen, Qingmei Liu, Zhi Zhou, Silin Zhang, Xiawen Liu* (共同通讯), Ning Hou*, Wei Yi*, Structure-based screening and biological validation of the anti-thrombotic drug-dicoumarol as a novel and potent PPARγ-modulating ligand. Bioorganic Chemistry, 2022, 129, 106191.
3. Xiawen Liu, Yi Rong, Xingfei Zhang, Junjun Huang, Yi Cai, Biyun Huang, Liu Zhu, Bo Wu, Ning Hou, Chengfeng Luo. Human UDP-Glucuronosyltransferase 2B4 and 2B7 are responsible for naftopidil glucuronidation in Vitro. Frontiers in Pharmacology. 2018, 8, 984.
4. Xiawen Liu, Lijun Zhu, Biyun Huang, Junjun Huang, Yi Cai, Liu Zhu, Bo Wu, Xiaojing Fu, Xingfei Zhang, Yi Rong, Qing Xiao, Jiewen Guo, Arong Li, Yifei Guo, Mu Yuan. Poor and enantioselective bioavailability of naftopidil enantiomers is due to extensive and stereoselective metabolism in rat liver. Journal of Pharmaceutical and Biomedical Analysis. 2017, 132, pp 165-172.
5. Yi Rong, Biyun Huang, Junjun Huang, Liu Zhu, Xiawen Liu (通讯作者). A rapid and simple ultraperformance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method for the detection of glucuronic acid-conjugated steroid metabolites. Journal of Chinese Pharmaceutical Sciences. 2016, 25(4), pp 291-301.
6. Xiawen Liu, Xingfei Zhang, Junjun Huang, Yi Rong, Chengfeng Luo, Jiewen Guo, Liu Zhu, Biyun Huang, Mu Yuan*. Enantiospecific determination of naftopidil by RRLC-MS/MS reveals stereoselective pharmacokinetics and tissue distributions in rats. Journal of Pharmaceutical and Biomedical Analysis. 2015, 112: 147-154.
7. Lijun Zhu#, Xiawen Liu#（共同一作）, Liu Zhu, Xingfei Zhang, Xiaojing Fu, J unjun Huang, Mu Yuan*. Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. Journal of Pharmacy and Pharmacology. 2014, 66(11):1534-1551
8. Yunying Zhang#, Xiawen Liu#（共同一作）, Mu Yuan*, Lijun Zhu. Simultaneous stereoselective analysis of naftopidil and O-desmethyl naftopidil enantiomers in rat feces using an online column-switching high performance liquid chromatography method. Journal of Biomedical Chromatography. 2014, 28:1030-1035
9. Xiawen Liu, Yunying Zhang, Mu Yuan*, Yinxiang Sun. Determination of Naftopidil enantiomers in rat plasma using chiral solid phases and pre-column derivatization high performance Liquid Chromatography. Journal of Chromatography B. 2012 (907) 140-145.
