林水木，男，博士，1986年2月生，福建漳州人，广州医科大学药学院，教授，博士生和硕士生导师，广医高水平大学建设“南山学者”骨干人才。本硕博均就读于华南理工大学，曾在新加坡眼科研究所担任Research Associate。针对目前严重缺乏新型抗耐药菌药物等关键科学问题，课题组结合药物化学、化学生物学、药理学、毒理学、基因组学和蛋白组学等多学科手段，研发抗耐药菌创新药物，探索药物抗菌机制，致力于解决微生物耐药性的难题。课题组主要研究方向为药物化学、抗感染新药研发和生物标志物的检测，至今已在Acc Chem Res, J Med Chem, Eur J Med Chem, Sensor Actuat B-Chem等期刊上发表SCI论文28篇。2020年至今以第一或通讯作者发表SCI论文15篇，含6篇J Med Chem和3篇Eur J Med Chem。2021年作为第一兼通讯作者应邀在化学顶级期刊Acc Chem Res上撰写关于黄酮类抗菌肽模拟物的综述论文。获授权中国发明专利2项。其中作为第一发明人的关于补骨脂酚类抗菌药物的专利于2021年成功转让给药企，由药企进行系统的临床前开发研究。

联系邮箱：linshuimu020@163.com；linshuimu@gzhmu.edu.cn.

研究方向：1、抗感染药物研发；2、药物化学；3、生物标志物的检测。

主要科研项目

目前主持的项目为广州医科大学高水平大学建设人才启动项目(B195002009030，100万)和国家自然科学基金青年项目(21907019，27万)和广州医科大学附属第六医院开放课题项目（202301-308，20万）。

主要代表性论文（近三年）：

(1) Cai, Qiongna; Yu, qian; Liang, Wanxin; Li, Haizhou; Liu, Jiayong; Li, Hongxia; Chen, Yongzhi; Fang, Shanfang; Zhong, Rongcui; Liu, Shouping*; Lin, Shuimu*. Membrane-Active Nonivamide Derivatives as Effective Broad-Spectrum Antimicrobials: Rational Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry, 2022, 65, 16754-16773. (IF=8.039，中科院一区)

(2) Liang, Wanxin; Yu, qian; Zheng, Zixian; Liu, Jiayong; Cai, Qiongna; Liu, Shouping*; Lin, Shuimu*; Design and Synthesis of Phenyl Sulfide-Based Cationic Amphiphiles as Membrane-Targeting Antimicrobial Agents against Gram-Positive Pathogens, Journal of Medicinal Chemistry, 2022, 65(20):14221-14236. (IF=8.039，中科院一区)

(3)  Liu, Jiayong#; Li, Hongxia#; Li, Haizhou; Fang, Shanfang; Shi, Jinguo; Chen, Yongzhi; Zhong, Rongcui; Liu, Shouping*; Lin, Shuimu*; Rational Design of Dipicolylamine-Containing Carbazole Amphiphiles Combined with Zn2+ as Potent Broad-Spectrum Antibacterial Agents with a Membrane-Disruptive Mechanism, Journal of Medicinal Chemistry, 2021, 64(14): 10429-10444

(4) Lin, Shuimu*; Wade, John D. *; Liu, Shouping*; De Novo Design of Flavonoid-Based Mimetics of Cationic Antimicrobial Peptides: Discovery, Development, and Applications, Accounts of Chemical Research, 2021, 54(1): 104-119. (IF=24.466，中科院一区)

(5) Li, Hongxia#; Liu, Jiayong#; Liu, Chuan-Fa; Li, Haizhou; Luo, Jiachun; Fang, Shanfang; Chen, Yongzhi; Zhong, Rongcui; Liu, Shouping*; Lin, Shuimu*; Design, Synthesis, and Biological Evaluation of Membrane-Active Bakuchiol Derivatives as Effective Broad-Spectrum Antibacterial Agents, Journal of Medicinal Chemistry, 2021, 64(9): 5603-5619. (IF=8.039，中科院一区)

(6) Lin, Shuimu; Li, Hongxia; Tao, Yiwen; Liu, Jiayong; Yuan, Wenchang; Chen, Yongzhi; Liu, Ying; Liu, Shouping*; In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria, Journal of Medicinal Chemistry, 2020, 63(11): 5797-5815. (IF=8.039，中科院一区)

(7) Lin, Shuimu; Liu, Jiayong; Li, Hongxia; Liu, Ying; Chen, Yongzhi; Luo, Jiachun; Liu, Shouping*; Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections, Journal of Medicinal Chemistry, 2020, 63(17): 9284-9299. (IF=8.039，中科院一区)

(8) Liu, Jiayong; Li, Hongxia; He, Qile; Chen, Kaiting; Chen, Yongzhi; Zhong, Rongcui; Li, Haizhou; Fang, Shanfang; Liu, Shouping*; Lin, Shuimu*; Design, synthesis, and biological evaluation of tetrahydroquinoline amphiphiles as membrane-targeting antimicrobials against pathogenic bacteria and fungi, European Journal of Medicinal Chemistry, 2022, 243: 114734

(9) Chen, Yongzhi; Li, Hongxia; Liu, Jiayong; Zhong, Rongcui; Li, Haizhou; Fang, Shanfang; Liu, Shouping*; Lin, Shuimu*; Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria, European Journal of Medicinal Chemistry, 2021, 226: 113813. (IF=7.088, 中科院一区)

(10) Lin, Shuimu#; Chen, Yongzhi#; Li, Hongxia; Liu, Jiayong; Liu, Shouping*; Design, synthesis, and evaluation of amphiphilic sofalcone derivatives as potent Gram-positive antibacterial agents, European Journal of Medicinal Chemistry, 2020, 202: 112596. (IF=7.088, 中科院一区)  

(11) Zhong, Rongcui#; Li, Haizhou#; Li, Hongxia; Fang, Shanfang; Liu, Jiayong; Chen, Yongzhi; Liu, Shouping*; Lin, Shuimu*; Development of Amphiphilic Coumarin Derivatives as Membrane-Active Antimicrobial Agents with Potent In Vivo Efficacy against Gram-Positive Pathogenic Bacteria., ACS Infectious Diseases, 2021, 7(10): 2864-2875. (IF=5.578, 中科院二区) 

主要专利（近三年）：

（1）林水木，刘寿平，栗宏霞，江鸿；补骨脂酚衍生物、其药学上可接受的盐及其制备方法和应用；授权号：ZL202011152645.9，授权日：2022-11-15。同时申请国际PCT专利，申请号：PCT/CN2020/125481，申请日期：2020-10-27。

（2）林水木，刘寿平，栗宏霞；黄酮类化合物及其制备方法和应用；申请号：201911257926.8；授权号：ZL 201911257926.8，授权日：2023-2-17。

（3）林水木，刘寿平，刘家勇；氯福克酚衍生物、抗菌药物及制备方法与应用；申请号：202210427128.0；申请日期：2022-04-22。同时申请国际PCT专利，申请号：PCT/CN2022/088513，申请日期：2022-04-22。

（4）林水木，刘寿平，梁婉欣；二苯硫醚化合物、抗菌药物及制备方法与应用；申请号：202210322575X；申请日期：2022-03-30。

（5）刘寿平，林水木，刘家勇；咔唑类化合物及其制备方法和应用；申请号：201911415794.7；申请日期：2019-12-31，公告日：2020-05-19。